Results 91 to 100 of about 1,436,982 (204)

Cortical Cholinergic Pathway Degeneration Reflects Cognitive Impairment and Dementia in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Cognitive impairment is a prevalent and debilitating feature of Parkinson's disease (PD). Increasing evidence from postmortem and in vivo positron emission tomography imaging studies supports cholinergic dysfunction in PD. There is, however, little evidence regarding the influence of the structural integrity of cortical cholinergic ...
Nicola M. Slater, Daniel J. Myall, Reza Shoorangiz, Wassilios G. Meissner, Ian J. Kirk, Ross J. Keenan, Rebecca M. Lee, Kyla‐Louise Horne, Michael R. MacAskill, Campbell J. Le Heron, Toni L. Pitcher, Tim J. Anderson, Tracy R. Melzer, John C. Dalrymple‐Alford   +13 more
wiley   +1 more source

Neuromelanin‐Sensitive MRI as a Marker of Clinical Severity and Disease Burden in Parkinson's Disease: A Systematic Review and Meta‐analysis

Movement Disorders, EarlyView.
Abstract The neuropathology of Parkinson's disease (PD) is characterized in part by the degeneration of catecholaminergic neurons, particularly dopaminergic neurons in the substantia nigra pars compacta (SNpc) and noradrenergic neurons in the locus coeruleus (LC), yet no validated in vivo biomarker quantifies this process.
Rayo Akande, Thomas Kustermann, Štefan Holiga, Judith Anzures‐Cabrera, Patrik Brundin, Gennaro Pagano   +5 more
wiley   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Movement disorders and nonmotor neuropsychological symptoms in children and adults with classical galactosemia [PDF]

, 2019
Although movement disorders (MDs) are known complications, the exact frequency and severity remains uncertain in patients with classical galactosemia, especially in children. We determined the frequency, classification and severity of MDs in a cohort of
Coenen, MA, Williams, M. (Martine), Grünewald, S. (Sonja), Lachmann, RHL, Janssen, MCH, Tijssen, M.A., Tijssen, MA, Eggink, H, Kuiper, A., Rubio-Gozalbo, M.E. (Estela), Zutt, R, Brouwers, M, Murphy, E, Bosch, AM, Murphy, E. (Elaine), van den Bosch, A.M., Lachmann, R.H.L., Zutt, R., Coenen, M.A., Kuiper, A, Derks, T.G.J. (Terry G J), Grunewald, S, Williams, Monique, Derks, TGJ, Janssen, M.C.H. (Mirian), Eggink, H., Koning, TJ, Brouwers, M. (M.), Koning, T.J. (Tom) de, Rubio-Gozalbo, ME   +29 more
core   +2 more sources

Physical activity and exercise participation—Impact on motor and non‐motor outcomes in early‐stage Parkinson disease: A cross‐sectional study

PM&R, EarlyView.
Abstract Background Aerobic exercise is beneficial in managing Parkinson disease (PD), yet its potential remains less clear in early stages. This study investigates the impact of long‐term aerobic exercise habits in individuals with early‐stage PD compared with healthy controls. Design Cross‐sectional study.
Cecilie Thrue, Frederik Bonde‐Jensen, Lars G. Hvid, Ulrik Dalgas, Martin Langeskov‐Christensen   +4 more
wiley   +1 more source

Effect of the Yon PD App on the Management of Self-Care in People With Parkinson Disease: Randomized Controlled Trial

Journal of Medical Internet Research
BackgroundAs the percentage of the older population increases, it is accompanied by an increase in the prevalence of Parkinson disease (PD).
JuHee Lee, Subin Yoo, Yielin Kim, Eunyoung Kim, Hyeran Park, Young H Sohn, Yun Joong Kim, Seok Jong Chung, Kyoungwon Baik, Kiyeon Kim, Jee-Hye Yoo   +10 more
doaj   +1 more source

Non-motor Symptoms of Parkinson's Disease

International Journal of Gerontology, 2007
In addition to the typical motor symptoms (resting tremor, cogwheel rigidity, bradykinesia, postural instability) of Parkinson's disease (PD), non-motor symptoms are sources of considerable burden in people with PD, espe-cially in elderly patients.
Jyh-Gong Gabriel Hou, Eugene C Lai
doaj   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Nonmotor disturbances in Parkinson's disease [PDF]

, 2010
Nonmotor disturbances (NMDs) affect most patients with Parkinson's disease (PD) and often have a profound impact on their quality of life. NMDs such as depression, anxiety, fatigue, REM sleep behavior disorder, constipation, delayed gastric emptying ...
Claudio L. Bassetti, Bassetti, Claudio L., Bassetti, C L, Bassetti CL   +3 more
core   +2 more sources

Levodopa and Subthalamic Nucleus Deep Brain Stimulation Modulate Excitation/Inhibition Balance and the Neural Encoding of Isochronous Sequences in Persons With Parkinson's Disease

Annals of the New York Academy of Sciences, Volume 1565, Issue 1, November 2026.
In this study, we show that levodopa and deep brain stimulation (DBS) interventions differently modulate excitation/inhibition balance at the brain level and how individuals with Parkinson's disease process temporally regular auditory sequences, as typically provided in rhythmic auditory cueing protocols.
Antonio Criscuolo, Michael Schwartze, Johannes Schwarz, Karl Strecker, Swen Hesse, Sonja A. Kotz   +5 more
wiley   +1 more source