Results 71 to 80 of about 1,436,982 (204)

Estimated presence of nonmotor symptoms in LRRK2 G2019S Parkinson’s disease patients and idiopathic Parkinson’s disease patients in relation to onset of motor symptoms.

, 2014
LRRK2 G2019S PD: LRRK2 G2019S related Parkinson’s disease; IPD: Idiopathic Parkinson’s disease, OMS: onset of motor symptoms, RBD: REM sleep behavior disorder, EDS: excessive daytime sleepiness.Estimated presence of nonmotor symptoms in LRRK2 G2019S ...
Jon Infante (646320), Inés García-Gorostiaga (646322), Mariateresa Buongiorno (646323), Miquel Aguilar (646325), Carles Gaig (527844), María Sierra (646321), Matilde Calopa (646326), Maria José Martí (302744), Eduardo Tolosa (646328), Jorge Hernandez-Vara (646327), Francesc Valldeoriola (302746), Mario Ezquerra (646324), Dolores Vilas (646319)   +12 more
core   +1 more source

Nonmotor Symptoms and Subthalamic Deep Brain Stimulation in Parkinson’s Disease [PDF]

, 2015
Subthalamic deep brain stimulation (STN DBS) is an established treatment for the motor symptoms in patients with advanced Parkinson’s disease (PD). In addition to improvements in motor symptoms, many studies have reported changes in various nonmotor ...
Beom S. Jeon, Sun Ha Paek, Han-Joon Kim
core   +1 more source

Impact of Weekly Community-Based Dance Training Over 8 Months on Depression and Blood Oxygen Level–Dependent Signals in the Subcallosal Cingulate Gyrus for People With Parkinson Disease: Observational Study

JMIRx Med
BackgroundDance has emerged as a complementary treatment that may promote adaptive neural plasticity while improving symptoms of Parkinson disease (PD), such as balance, gait, posture, and walking.
Karolina A Bearss, Rebecca E Barnstaple, Rachel J Bar, Joseph F X DeSouza   +3 more
doaj   +1 more source

The Possible Clinical Predictors of Fatigue in Parkinson’s Disease: A Study of 135 Patients as Part of International Nonmotor Scale Validation Project

Parkinson's Disease, 2011
Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson’s disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated.
Vinod Metta, Kartik Logishetty, P. Martinez-Martin, Heather M. Gage, P. E. S. Schartau, T. K. Kaluarachchi, Anne Martin, Per Odin, P. Barone, Fabrizio Stocchi, A. Antonini, K. Ray Chaudhuri   +11 more
doaj   +1 more source

Real‐World Evaluation of Bilateral Magnetic Resonance–Guided Focused Ultrasound Thalamotomy in Essential Tremor

Movement Disorders, EarlyView.
Abstract Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is effective in treating essential tremor (ET) with an adequate safety profile. Objective The aim of the study was to evaluate the real‐world safety and efficacy of staged bilateral MRgFUS thalamotomy in ET and its impact on patient's quality of life (QoL) and patient‐
Dolores Vilas, Antonio Gonzalez, Manel Tardáguila, Lourdes Ispierto, Mireia Gea, José Antonio Pérez, Raquel García, Ramiro Álvarez, Jorge Muñoz   +8 more
wiley   +1 more source

The impact of deep brain stimulation on the nonmotor symptoms of Parkinson's disease

, 2013
Deep brain stimulation (DBS) is a well-established therapy for patients with advanced Parkinson's disease (PD) with clear benefits on many of the motor symptoms. The effects of DBS on the nonmotor symptoms are less well examined.
Samuel, Michael, Reddy, Prashanth, Ashkan, Keyoumars, Ray Chaudhuri, K.   +3 more
core   +1 more source

The Costs of Parkinson's Disease in Europe: Results of the Costs of Illness in Neurology Initiative

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. It imposes substantial and growing burden on patients, families, and caregivers and reduces quality of life. The disability and care needs associated with PD carry economic ramifications.
Luisa Welter, Christopher Kruse, Mateo Montes‐Martinez, Paul Boon, Claudio Bassetti, Thomas Berger, Elena Moro, Maria Konti, Maria Lolich, Alessandro Tessitore, Amelia Hursey, Marjan Arvandi, Nikolai Mühlberger, Uwe Siebert, Richard Dodel, Günther Deuschl   +15 more
wiley   +1 more source

The Effect of LRRK2 and GBA1 Mutations on Survival in Early‐ and Late‐Onset Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Mutations in the glucocerebrosidase 1 (GBA1) and leucine‐rich repeat kinase 2 (LRRK2) genes are associated with Parkinson's disease (PD) phenotype. Objective To asses the contribution of genetic status to long‐term survival of patients with PD.
Raz Rubin, Roy N. Alcalay, Nurit Omer, Orly Goldstein, Mali Gana Weisz, Anat Mirelman, Avner Thaler   +6 more
wiley   +1 more source

Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease? [PDF]

, 2011
Evidence suggests that both motor and nonmotor symptoms contribute to health status in Parkinson's disease. Less clear is how much change in health status can be expected if these clinical variables change. In addition, anxiety, separate from depression,
Brown, Richard G.; id_orcid, Samuel, Michael, Hinnell, C., Michael Samuel, Samuel, M., Sabine Landau, Hindle, J. V., Richard G. Brown, Catherine S. Hurt, Hinnell, Claire, Claire Hinnell, Brown, R. G., Wilson, K. C., null null, Burn, D. J., Hurt, Catherine S., Landau, Sabine; id_orcid, Landau, S., Hurt, C. S.   +18 more
core   +1 more source

Levodopa and Melanoma: Practical Recommendations for Parkinson's Disease—International Parkinson and Movement Disorder Society Scientific Issues Committee Viewpoint

Movement Disorders Clinical Practice, EarlyView.
Giorgia Sciacca, Inas Elsayed, Santiago Perez‐Lloret, Tiago F. Outeiro, Vivek K. Unni, Jeffery H. Kordower, Daniela Berg, Lorraine V. Kalia, on behalf of the MDS Scientific Issues Committee, Jane Alty, Alexander Balck, Daniela Berg, Per Borghammer, Inas Elsayed, Yue Huang, Walaa Kamel Elsayed, Jeffrey Kordower, Alexander Lehn, Michele Matarazzo, Tiago Mestre, Tiago Outeiro, Gian Pal, Santiago Perez Lloret, Roopa Rajan, Sephira Ryman, Giorgia Sciacca, Per Svenningsson, Lorraine Kalia   +27 more
wiley   +1 more source