Results 121 to 130 of about 463,256 (209)

Cell-free protein synthesis for nonribosomal peptide synthetic biology

Frontiers in Natural Products
Peptide natural products have a wide range of useful applications as pesticides, veterinary agents, pharmaceuticals, and bioproducts. To discover new natural products, manipulate them for analog generation, and to harness the potential of these bioactive
Tien T. Sword, Ghaeath S. K. Abbas, Constance B. Bailey   +2 more
doaj   +1 more source

High mass accuracy analytical applications of Fourier transform ion cyclotron resonance mass spectrometry [PDF]

The performance capabilities of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry are higher than any other type of mass spectrometer, making this technique suitable for a range of analytical applications.
Wills, Rebecca Helen
core  

Desymmetrization of Cyclodepsipeptides by Assembly Mode Switching of Iterative Nonribosomal Peptide Synthetases

, 2019
Nonribosomal peptide synthetases assemble a considerable number of structurally complex peptides of pharmacological importance. This turns them into important biosynthetic machineries for peptide diversification by engineering approaches.
Sylvester Hoffmann (6481823), Roderich D. Süssmuth (1432969), Charlotte Steiniger, Sylvester Hoffmann, Charlotte Steiniger (6481820), Roderich D. Süssmuth   +5 more
core   +1 more source

Recent advances in engineering nonribosomal peptide assembly lines.

, 2016
Covering: up to July 2015Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications.
Winn, Michael, Micklefield, J, Fyans, Joanna, Zhuo, Ying   +3 more
core   +1 more source

Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases

, 2016
Nonribosomal peptide synthetases are large, complex multidomain enzymes responsible for the biosynthesis of a wide range of peptidic natural products. Inherent to synthetase chemistry is the thioester templated mechanism that relies on protein/protein ...
Naga Sandhya Guntaka (2852846), Wei-Hung Chen (693540), Kunhua Li (1576657), Steven D. Bruner (1576660)   +3 more
core   +1 more source

Structural and functional characterization of the triplet acyl carrier protein in the curacin cluster and its interaction partners [PDF]

, 2012
According to the World Health Organization (WHO) bacterial resistance to antibiotic drug therapy is emerging as a major public health problem around the world. Infectious diseases seriously threaten the health and economy of all countries.
Busche, Alena (Dr.)
core  

Nonribosomal peptide synthetases

, 2018
Nonribosomal peptide synthetases or NRPS, are extraordinarily large, modular and complex molecular machines responsible for the production of important bioactive compounds, such as antibiotics, anti-cancer drugs as well as pigments, among many others. Even though it has become increasingly simple to identify and partially classify this kind of enzyme ...
openaire   +1 more source

Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases

Bacterial biosynthetic assembly lines, such as nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), play a crucial role in the synthesis of natural products that have significant therapeutic potential.
Kenan A. J. Bozhueyuek (16716446), Nadya Abbood (16716440), Juliana Effert (16716443), Helge B. Bode (195839)   +3 more
core   +1 more source

Charting the Biosynthetic Landscape of Hybrid Polyketide-Nonribosomal Peptide-Specialized Lipids. [PDF]

JACS Au
El Arnouki Belhaji F, De Ruysscher D, Vanreppelen G, Huybrechts LL, Alanjary MM, Zdouc MM, de Los Santos ELC, Demaerel J, Vaneeckhaute E, Van Goethem O, Gerstmans H, Breynaert E, Van Dijck P, Medema MH, Weir ANM, Lescrinier E, Masschelein J.   +16 more
europepmc   +1 more source

Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases. [PDF]

ACS Synth Biol, 2023
Abbood N, Effert J, Bozhueyuek KAJ, Bode HB.   +3 more
europepmc   +1 more source