Results 91 to 100 of about 627,327 (211)

Delftibactin-A, a Non-ribosomal Peptide With Broad Antimicrobial Activity

Frontiers in Microbiology, 2019
The rapid emergence of drug resistant bacteria is occurring worldwide, outpacing the development of new antibiotics. It is known that some of the main sources of antibiotics are the bacteria themselves, many of which are secondary metabolites of Gram ...
Noa Tejman-Yarden, Noa Tejman-Yarden, Ari Robinson, Yaakov Davidov, Alexander Shulman, Alexander Varvak, Fernando Reyes, Galia Rahav, Galia Rahav, Israel Nissan, Israel Nissan   +10 more
doaj   +1 more source

[Biologically active nonribosomal peptides. II. Nonribosomal peptides of various biological action].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2012
The second part of the review concerned with investigation of nonribosomal peptides.
T. I. Orlova, V. G. Bulgakova, A. N. Polin   +2 more
openaire   +2 more sources

Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides

, 2019
Pairs of docking domains (DDs) mediate the selective interations between adjacent nonribosomal peptide synthetases (NRPSs) to form defined protein–protein interactions resulting in defined peptide sequences.
Bode, H., Cai, X., Helge B. Bode (195839), Zhao, L., Xiaofeng Cai (693709), Lei Zhao (144153)   +5 more
core   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, Volume 293, Issue 21, Page 6413-6425, November 2026.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Structural basis of nonribosomal peptide macrocyclization in fungi [PDF]

Nature Chemical Biology, 2016
Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (CT) domain and the holo thiolation (T)-CT complex ...
Jinru, Zhang, Nicholas, Liu, Ralph A, Cacho, Zhou, Gong, Zhu, Liu, Wenming, Qin, Chun, Tang, Yi, Tang, Jiahai, Zhou   +8 more
openaire   +2 more sources

Sustainable Routes Toward Amino Acid‐Based Surfactants: Borrowing Hydrogen Catalysis and Beyond

ChemSusChem, Volume 19, Issue 20, 28 October 2026.
This perspective examines how amino acid‐based surfactants become more sustainable only when molecular architecture is matched to an appropriate synthetic disconnection. Borrowing Hydrogen catalysis provides a central route to N‐alkylated derivatives, while enzymatic, biosynthetic, and renewable‐platform strategies complement it.
Maximilian Fellert, Ben L. Feringa
wiley   +1 more source

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

, 1999
Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products.
Walsh, Christopher T, Cane, David E
core   +1 more source

Virulence, Host-Selective Toxin Production, and Development of Three Cochliobolus Phytopathogens Lacking the Sfp-Type 4′-Phosphopantetheinyl Transferase Ppt1

Molecular Plant-Microbe Interactions, 2015
The Sfp-type 4′-phosphopantetheinyl transferase Ppt1 is required for activation of nonribosomal peptide synthetases, including α-aminoadipate reductase (AAR) for lysine biosynthesis and polyketide synthases, enzymes that biosynthesize peptide and ...
Nur Ain Izzati Mohd Zainudin, Bradford Condon, Lieselotte De Bruyne, Christof Van Poucke, Qing Bi, Wei Li, Monica Höfte, B. Gillian Turgeon   +7 more
doaj   +1 more source

Mining the Yucatan Coastal Microbiome for the Identification of Non-Ribosomal Peptides Synthetase (NRPS) Genes

Toxins, 2020
Prokaryotes represent a source of both biotechnological and pharmaceutical molecules of importance, such as nonribosomal peptides (NRPs). NRPs are secondary metabolites which their synthesis is independent of ribosomes.
Mario Alberto Martínez-Núñez, Zuemy Rodríguez-Escamilla   +1 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source