Results 121 to 130 of about 10,782 (215)

High mass accuracy analytical applications of Fourier transform ion cyclotron resonance mass spectrometry [PDF]

The performance capabilities of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry are higher than any other type of mass spectrometer, making this technique suitable for a range of analytical applications.
Wills, Rebecca Helen
core  

Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters

, 2010
The genome of the erythromycin-producing bacterium Saccharopolyspora erythraea contains many orphan secondary metabolite gene clusters including two (nrps3 and nrps5) predicted to govern biosynthesis of nonribosomal peptide-based siderophores.
Lazos, Orestis, Sidebottom, Philip J., Slusarczyk, Adrian L., Cortés, Jesus, Tosin, Manuela, Leadlay, Peter F., Leadlay, P. F., Boakes, Steven   +7 more
core   +1 more source

Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases

Bacterial biosynthetic assembly lines, such as nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), play a crucial role in the synthesis of natural products that have significant therapeutic potential.
Kenan A. J. Bozhueyuek (16716446), Nadya Abbood (16716440), Juliana Effert (16716443), Helge B. Bode (195839)   +3 more
core   +1 more source

Nonribosomal peptide synthetases

, 2018
Nonribosomal peptide synthetases or NRPS, are extraordinarily large, modular and complex molecular machines responsible for the production of important bioactive compounds, such as antibiotics, anti-cancer drugs as well as pigments, among many others. Even though it has become increasingly simple to identify and partially classify this kind of enzyme ...
openaire   +1 more source

Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases. [PDF]

ACS Synth Biol, 2023
Abbood N, Effert J, Bozhueyuek KAJ, Bode HB.   +3 more
europepmc   +1 more source

Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a Burkholderia bacterium. [PDF]

Proc Natl Acad Sci U S A, 2023
Romanowski SB, Lee S, Kunakom S, Paulo BS, Recchia MJJ, Liu DY, Cavanagh H, Linington RG, Eustáquio AS.   +8 more
europepmc   +1 more source

Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated <i>Paenibacillus</i> species. [PDF]

mSystems
Machushynets NV, Elsayed SS, Du C, Lysenko V, de la Cruz M, Sanchez P, Genilloud O, Martin NI, Liles MR, van Wezel GP.   +9 more
europepmc   +1 more source

Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases. [PDF]

Angew Chem Int Ed Engl
Diecker J, Hermanns B, Rüschenbaum J, Rasche R, Dörner W, Schröder A, Kümmel D, Mootz HD.   +7 more
europepmc   +1 more source

Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks. [PDF]

Biochemistry
Ratnayake MS, Jian X, Tailhades J, Challis GL, Hansen MH, Lewandowski JR, Cryle MJ.   +6 more
europepmc   +1 more source

Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module. [PDF]

ACS Chem Biol, 2023
Murphy AC, Corney M, Monson RE, Matilla MA, Salmond GPC, Leeper FJ.   +5 more
europepmc   +1 more source