Results 101 to 110 of about 526 (132)
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Pseudoaeruginosins, Nonribosomal Peptides in Nodularia spumigena
ACS Chemical Biology, 2014Nodularia spumigena is a filamentous cyanobacterium that forms toxic blooms in brackish waters around the world through the production of the pentapeptide toxin nodularin. This cyanobacterium also produces large amounts of protease inhibitors belonging to the aeruginosin and spumigin families. Here we report the discovery of previously unknown protease
Liwei, Liu +9 more
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Synthesis of the Nonribosomal Peptide Phevalin and Analogs
The Journal of Organic Chemistry, 2019Phevalin, a cyclic nonribosomal peptide produced by Staphylococcus aureus, has intriguing biological properties. A synthetic route to access phevalin and similar pyrazinone natural products tyrvalin, leuvalin, phileucin, and a few synthetic analogs is described.
Remya Ramesh +3 more
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De Novo Sequencing of Nonribosomal Peptides
2008While nonribosomal peptides (NRPs) are of tremendous pharmacological importance, there is currently no technology capable of high-throughput sequencing of NRPs. Difficulties in sequencing NRPs slow down the progress in elucidating the non-ribosomal genetic code and negatively affect various screening programs aimed at the discovery of natural compounds
Nuno Bandeira +5 more
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Metagenome Driven Discovery of Nonribosomal Peptides
ACS Chemical Biology, 2019Declining rates of novel natural product discovery and exponential rates of rediscovery heralded the end of the 1940s to 1960s "golden era" of antibiotic discovery. Fifty years later, the implementation of molecular screening methodologies revealed that standard culture-based screening approaches had failed to capture the vast majority of environmental
Luke J. Stevenson +2 more
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Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis
Natural Product Reports, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Florian, Kopp, Mohamed A, Marahiel
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Biosynthetic engineering of nonribosomal peptide synthetases
Journal of Peptide Science, 2016From the evolutionary melting pot of natural product synthetase genes, microorganisms elicit antibiotics, communication tools, and iron scavengers. Chemical biologists manipulate these genes to recreate similarly diverse and potent biological activities not on evolutionary time scales but within months. Enzyme engineering has progressed considerably in
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Peptide Natural Products II: Nonribosomal Peptides
2022Peptide natural products assembled by nonribosomal peptide synthetase (NRPS) machinery activate proteinogenic and nonproteinogenic amino acids, install them as thioesters tethered to phosphopantetheinyl prosthetic groups on peptidyl carrier protein domains, and carry out chain elongations by amide bond formations.
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Characterization of Nonribosomal Peptide Synthetases with NRPSsp
2016Bioinformatic sequence analysis allows the functional characterization of newly sequenced proteins. Nonribosomal peptide synthetases (NRPSs) are multi-modular enzymes involved in the biosynthesis of natural products. The current omics era has enabled the exponential growth of the sequenced NRPS, and it is important to characterize the final product of ...
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Bioinformatics Tools for the Discovery of New Nonribosomal Peptides
2016This chapter helps in the use of bioinformatics tools relevant to the discovery of new nonribosomal peptides (NRPs) produced by microorganisms. The strategy described can be applied to draft or fully assembled genome sequences. It relies on the identification of the synthetase genes and the deciphering of the domain architecture of the nonribosomal ...
Leclère, Valérie +3 more
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A male-derived nonribosomal peptide pheromone controls female schistosome development
Cell, 2022, Elliott M Ross, Ralph Deberardinis
exaly