Results 111 to 120 of about 494,637 (215)
Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus
Small StructuresThe biosynthesis of pseurotin A, a fungal metabolite with antibiotic and immunosuppressive properties, involves a group of enzymes, including a polyketide‐nonribosomal peptide synthase (PKS‐NRPS), PsoA, and a bifunctional enzyme, PsoF. PsoA consists of a
Lei Sun +5 more
doaj +1 more source
A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines
, 2016 A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free
Neil Garg (2216656) +5 more
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Cell-free protein synthesis for nonribosomal peptide synthetic biology
Frontiers in Natural ProductsPeptide natural products have a wide range of useful applications as pesticides, veterinary agents, pharmaceuticals, and bioproducts. To discover new natural products, manipulate them for analog generation, and to harness the potential of these bioactive
Tien T. Sword +2 more
doaj +1 more source
High mass accuracy analytical applications of Fourier transform ion cyclotron resonance mass spectrometry [PDF]
The performance capabilities of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry are higher than any other type of mass spectrometer, making this technique suitable for a range of analytical applications.
Wills, Rebecca Helen
core
, 2019 Nonribosomal peptide synthetases assemble a considerable number of structurally complex peptides of pharmacological importance. This turns them into important biosynthetic machineries for peptide diversification by engineering approaches.
Sylvester Hoffmann (6481823) +5 more
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Recent advances in engineering nonribosomal peptide assembly lines.
, 2016 Covering: up to July 2015Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications.
Winn, Michael +3 more
core +1 more source
, 2016 Nonribosomal peptide synthetases are large, complex multidomain enzymes responsible for the biosynthesis of a wide range of peptidic natural products. Inherent to synthetase chemistry is the thioester templated mechanism that relies on protein/protein ...
Naga Sandhya Guntaka (2852846) +3 more
core +1 more source
Structural and functional characterization of the triplet acyl carrier protein in the curacin cluster and its interaction partners [PDF]
, 2012 According to the World Health Organization (WHO) bacterial resistance to antibiotic drug therapy is emerging as a major public health problem around the world. Infectious diseases seriously threaten the health and economy of all countries.
Busche, Alena (Dr.)
core
Nonribosomal peptide synthetases
, 2018 Nonribosomal peptide synthetases or NRPS, are extraordinarily large, modular and complex molecular machines responsible for the production of important bioactive compounds, such as antibiotics, anti-cancer drugs as well as pigments, among many others. Even though it has become increasingly simple to identify and partially classify this kind of enzyme ...
openaire +1 more source
Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases
Bacterial biosynthetic assembly lines, such as nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), play a crucial role in the synthesis of natural products that have significant therapeutic potential.
Kenan A. J. Bozhueyuek (16716446) +3 more
core +1 more source