Results 101 to 110 of about 494,636 (171)
ANTI-BACTERIAL PROPERTY OF A CORAL-ASSOCIATED BACTERIUM Bacillus sp. AGAINST CORAL PATHOGENIC [PDF]
, 2006 Marine organisms such as corals are frequently colonized by bacteria that may be pathogenic to them. One of the means by which they are able to combat microbial attack is by chemical defense.
Radjasa, Ocky Karna, Sabdono, Agus
core +1 more source
Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart +7 more
wiley +1 more source
Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.
PLoS Pathogens, 2007 Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen.
Markus Schrettl +9 more
doaj +1 more source
Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr‐Pyrazole Chemistry
ChemMedChem, Volume 21, Issue 17, 14 September 2026.The glycopeptide antibiotics (GPAs) are important clinical antibiotics. While chemoenzymatic synthesis of more hydrophilic GPAs like vancomycin has aided our understanding of GPA crosslinking, hydrophobic GPAs remain underexplored. Here, we show that modified Knorr‐pyrazole chemistry improves access to hydrophobic peptidyl‐CoAs, with such substrates ...
Jemma Gullick +4 more
wiley +1 more source
, 2016 Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product ...
Yue Zhang (30585) +7 more
core +1 more source
Identification and structure of nonribosomal peptide synthetases in Cochliobolus miyabeanus TG12bL2.
, 2016 Identification and structure of nonribosomal peptide synthetases in Cochliobolus miyabeanus TG12bL2.
Juan J. Gutierrez-Gonzalez (131256) +6 more
core +1 more source
Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides
, 2019 Pairs of docking domains (DDs) mediate the selective interations between adjacent nonribosomal peptide synthetases (NRPSs) to form defined protein–protein interactions resulting in defined peptide sequences.
Bode, H. +5 more
core +1 more source
Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus
Small StructuresThe biosynthesis of pseurotin A, a fungal metabolite with antibiotic and immunosuppressive properties, involves a group of enzymes, including a polyketide‐nonribosomal peptide synthase (PKS‐NRPS), PsoA, and a bifunctional enzyme, PsoF. PsoA consists of a
Lei Sun +5 more
doaj +1 more source
A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines
, 2016 A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free
Neil Garg (2216656) +5 more
core +1 more source
Cell-free protein synthesis for nonribosomal peptide synthetic biology
Frontiers in Natural ProductsPeptide natural products have a wide range of useful applications as pesticides, veterinary agents, pharmaceuticals, and bioproducts. To discover new natural products, manipulate them for analog generation, and to harness the potential of these bioactive
Tien T. Sword +2 more
doaj +1 more source