Results 121 to 130 of about 526,871 (218)

A portable pathway specific transcription factor-promoter circuit enables heterologous production of fungal nonribosomal peptides

Most fungal nonribosomal peptide synthetase (NRPS) biosynthetic gene clusters remain transcriptionally silent, severely restricting the discovery of bioactive peptide metabolites. Standard constitutive promoters fail to support robust expression of large.
Zedong Ren, Jie Fan, Peng-Lin Wei, Jinwei Ren, Wenbing Yin, Yuanyuan Li, Shengquan Zhang   +6 more
core   +1 more source

The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers N_β-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis

, 2016
The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers Nβ-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic ...
J. Martin Bollinger (450755), Stefanie B. Bumpus (2135821), Megan L. Matthews (2232757), Neil L. Kelleher (548328), Christopher T. Walsh (1265718), Marie A. Hollenhorst (2199637)   +5 more
core   +1 more source

Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters

, 2010
The genome of the erythromycin-producing bacterium Saccharopolyspora erythraea contains many orphan secondary metabolite gene clusters including two (nrps3 and nrps5) predicted to govern biosynthesis of nonribosomal peptide-based siderophores.
Lazos, Orestis, Sidebottom, Philip J., Slusarczyk, Adrian L., Cortés, Jesus, Tosin, Manuela, Leadlay, P. F., Boakes, Steven   +6 more
core   +1 more source

Recent advances in engineering nonribosomal peptide assembly lines.

, 2016
Covering: up to July 2015Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications.
Winn, Michael, Micklefield, J, Fyans, Joanna, Zhuo, Ying   +3 more
core   +1 more source

Nonribosomal peptide synthetases

, 2018
Nonribosomal peptide synthetases or NRPS, are extraordinarily large, modular and complex molecular machines responsible for the production of important bioactive compounds, such as antibiotics, anti-cancer drugs as well as pigments, among many others. Even though it has become increasingly simple to identify and partially classify this kind of enzyme ...
openaire   +1 more source

High mass accuracy analytical applications of Fourier transform ion cyclotron resonance mass spectrometry [PDF]

The performance capabilities of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry are higher than any other type of mass spectrometer, making this technique suitable for a range of analytical applications.
Wills, Rebecca Helen
core  

Charting the Biosynthetic Landscape of Hybrid Polyketide-Nonribosomal Peptide-Specialized Lipids. [PDF]

JACS Au
El Arnouki Belhaji F, De Ruysscher D, Vanreppelen G, Huybrechts LL, Alanjary MM, Zdouc MM, de Los Santos ELC, Demaerel J, Vaneeckhaute E, Van Goethem O, Gerstmans H, Breynaert E, Van Dijck P, Medema MH, Weir ANM, Lescrinier E, Masschelein J.   +16 more
europepmc   +1 more source

Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases. [PDF]

ACS Synth Biol, 2023
Abbood N, Effert J, Bozhueyuek KAJ, Bode HB.   +3 more
europepmc   +1 more source

DeepAden: an explainable machine learning method for predicting the substrate specificity of nonribosomal peptide synthetases. [PDF]

Nucleic Acids Res
Huang J, Ge L, Wu Y, Tian Y, Wu J, Gao Q, Li P, Meng S, Zhang H, Qin Z.   +9 more
europepmc   +1 more source

High-Throughput Engineering of Nonribosomal Extension Modules

Nonribosomal peptides constitute an important class of natural products that display a wide range of bioactivities. They are biosynthesized by large assembly lines called nonribosomal peptide synthetases (NRPSs).
Donald Hilvert (105097), Anna Camus (13752672), Maximilian Gantz (13114354)   +2 more
core   +1 more source