Results 101 to 110 of about 494,637 (215)
Verrucacrylic Acids A and B From a Marine Sponge‐derived Verrucosispora sp. FIM06025
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Three new compounds, including two rare cyclopropane‐containing compounds, verrucacrylic acids A and B (1 and 2), and a new amino acid derivative (3), were isolated from Verrucosispora sp. FIM06025, 1 and 2 exhibited weak cytotoxic activity against HL‐60 and T47D. ABSTRACT Verrucosispora sp.
Minghong Chen +4 more
wiley +1 more source
ANTI-BACTERIAL PROPERTY OF A CORAL-ASSOCIATED BACTERIUM Bacillus sp. AGAINST CORAL PATHOGENIC [PDF]
, 2006 Marine organisms such as corals are frequently colonized by bacteria that may be pathogenic to them. One of the means by which they are able to combat microbial attack is by chemical defense.
Radjasa, Ocky Karna, Sabdono, Agus
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Fifteen new actinomycin analogs, named actinomycins H1–H15, are identified from S. polyantibioticus S4D258. Actinomycins H7–H15 are truncated actinomycin analogs. Actinomycins H1–H6 and H9 exhibit significant antiproliferative activities against both MDA‐MB‐231 and 4T1 TNBC cells.
He Pang +4 more
wiley +1 more source
Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.
PLoS Pathogens, 2007 Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen.
Markus Schrettl +9 more
doaj +1 more source
Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart +7 more
wiley +1 more source
, 2016 Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product ...
Yue Zhang (30585) +7 more
core +1 more source
Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi [PDF]
, 2016 Filamentous fungi are historically known as rich sources for production of biologically active natural products, so-called secondary metabolites. One particularly pharmaceutically relevant chemical group of secondary metabolites is the nonribosomal peptides synthesized by nonribosomal peptide synthetases (NRPSs).
Alexandra A, Soukup +2 more
openaire +2 more sources
Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr‐Pyrazole Chemistry
ChemMedChem, Volume 21, Issue 17, 14 September 2026.The glycopeptide antibiotics (GPAs) are important clinical antibiotics. While chemoenzymatic synthesis of more hydrophilic GPAs like vancomycin has aided our understanding of GPA crosslinking, hydrophobic GPAs remain underexplored. Here, we show that modified Knorr‐pyrazole chemistry improves access to hydrophobic peptidyl‐CoAs, with such substrates ...
Jemma Gullick +4 more
wiley +1 more source
Identification and structure of nonribosomal peptide synthetases in Cochliobolus miyabeanus TG12bL2.
, 2016 Identification and structure of nonribosomal peptide synthetases in Cochliobolus miyabeanus TG12bL2.
Juan J. Gutierrez-Gonzalez (131256) +6 more
core +1 more source
Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides
, 2019 Pairs of docking domains (DDs) mediate the selective interations between adjacent nonribosomal peptide synthetases (NRPSs) to form defined protein–protein interactions resulting in defined peptide sequences.
Bode, H. +5 more
core +1 more source