Results 51 to 60 of about 526,871 (218)
Engineering DNA-Templated Nonribosomal Peptide Synthesis [PDF]
Cell Chemical Biology, 2020 Abstract Nanocontainers or macromolecular scaffolds for artificial biocatalytic cascades facilitate sequential enzyme reactions but diffusive escape of intermediates limits rate enhancement. Nonribosomal peptide synthetases (NRPS) naturally form gigantic assembly lines and prevent escape by covalently tethering intermediates.
Hsin-Mei Huang +2 more
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Molecular Plant-Microbe Interactions, 2006 Cyclic lipopeptides (CLPs) are versatile molecules produced by a variety of bacterial genera, including plant-associated Pseudomonas spp. CLPs are composed of a fatty acid tail linked to a short oligopeptide, which is cyclized to form a lactone ring ...
Jos M. Raaijmakers +2 more
doaj +1 more source
Mechanistic analysis of nonribosomal peptide synthetases [PDF]
, 2021 Considering the ongoing rise of the multidrug-resistant bacterial infections, it is essential to expand the available repertoire of therapeutic agents.
Stanišić, Aleksa
core
Characterization of cereulide synthetase, a toxin-producing macromolecular machine.
PLoS ONE, 2015 Cereulide synthetase is a two-protein nonribosomal peptide synthetase system that produces a potent emetic toxin in virulent strains of Bacillus cereus.
Diego A Alonzo +2 more
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MicrobiologyOpen, 2016 Kalimantacin is an antimicrobial compound with strong antistaphylococcal activity that is produced by a hybrid trans‐acyltransferase polyketide synthase/nonribosomal peptide synthetase system in Pseudomonas fluorescens BCCM_ID9359.
Birgit Uytterhoeven +6 more
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Piecing together nonribosomal peptide synthesis
Current Opinion in Structural Biology, 2018 Nonribosomal peptide synthetases (NRPSs) produce peptide products with wide-ranging biological activities. NRPSs are macromolecular machines with modular assembly-line logic, a complex catalytic cycle, moving parts and multiple active sites. They are organized into repeating sets of domains, called modules.
Reimer, Janice M. +3 more
openaire +3 more sources
, 2023 Nonribosomal peptide synthetases produce many important peptide natural products and are centred around carrier proteins (CPs) that deliver intermediates to various catalytic domains.
Tailhades, Julien +8 more
core +1 more source
Frontiers in Microbiology, 2015 Paenibacillus polymyxa is a common soil bacterium with broad range of practical applications. An important group of secondary metabolites in P. polymyxa are nonribosomal peptide and polyketide derived metabolites (NRP/PK).
Salme eTimmusk
doaj +1 more source
Dissecting and Exploiting Nonribosomal Peptide Synthetases
Acta Biochimica et Biophysica Sinica, 2004 A large number of therapeutically useful cyclic and linear peptides of bacteria or fungal origin are synthesized via a template-directed, nucleic-acid-independent nonribosomal mechanism. This process is carried out by mega-enzymes called nonribosomal peptide synthetases (NRPSs).
Qing-Tao, Shen +3 more
openaire +2 more sources
Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst
, 2016 A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide−peptide products.
Charles R. Robertson (2253277) +5 more
core +1 more source