Results 41 to 50 of about 526,871 (218)

Pentaminomycins C–E: Cyclic Pentapeptides as Autophagy Inducers from a Mealworm Beetle Gut Bacterium

Microorganisms, 2020
Pentaminomycins C–E (1–3) were isolated from the culture of the Streptomyces sp. GG23 strain from the guts of the mealworm beetle, Tenebrio molitor. The structures of the pentaminomycins were determined to be cyclic pentapeptides containing a modified ...
Sunghoon Hwang, Ly Thi Huong Luu Le, Shin-Il Jo, Jongheon Shin, Min Jae Lee, Dong-Chan Oh   +5 more
doaj   +1 more source

Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module

Nature Communications, 2022
Nonribosomal peptide synthetases work with additional enzymes to synthesise secondary metabolites and therapeutics. Here, the authors explore bacillamide D synthesis and show the oxidase action is done while the intermediate is attached to the synthetase
Camille Marie Fortinez, Kristjan Bloudoff, Connor Harrigan, Itai Sharon, Mike Strauss, T. Martin Schmeing   +5 more
doaj   +1 more source

Nonribosomal Peptide Synthesis and Toxigenicity of Cyanobacteria [PDF]

Journal of Bacteriology, 1999
ABSTRACT Nonribosomal peptide synthesis is achieved in prokaryotes and lower eukaryotes by the thiotemplate function of large, modular enzyme complexes known collectively as peptide synthetases. These and other multifunctional enzyme complexes, such as polyketide synthases, are of interest due to their use in unnatural-product or ...
B A, Neilan, E, Dittmann, L, Rouhiainen, R A, Bass, V, Schaub, K, Sivonen, T, Börner   +6 more
openaire   +2 more sources

Novel chemical probes for the investigation of nonribosomal peptide assembly [PDF]

, 2017
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights
Manuela Tosin, Y. T. C. Ho, Bushell, Dexter P., Ho, Y. T. Candace, Ghiringhelli, Francesca, Havemann, Judith, O. Köstner, Wilkening, Ina, E. Riva, Daniel J. Leng, Elena Riva, Riva, Elena, Judith Havemann, Francesca Ghiringhelli, J. Havemann, Otto Köstner, Leng, Daniel J., Passarella, Daniele, Dexter P. Bushell, I. Wilkening, Y. T. Candace Ho, D. P. Bushell, D. Passarella, M. Tosin, Daniele Passarella, F. Ghiringhelli, Ina Wilkening, Tosin, Manuela, Köstner, Otto, D. J. Leng   +29 more
core   +1 more source

Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain

Nature Communications, 2022
The catalytic domains in nonribosomal peptide synthetases (NRPSs) are responsible for a choreography of events that elongates substrates into natural products.
Jialiang Wang, Dandan Li, Lu Chen, Wei Cao, Liangliang Kong, Wei Zhang, Tristan Croll, Zixin Deng, Jingdan Liang, Zhijun Wang   +9 more
doaj   +1 more source

Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5‐Triazine Nucleoside Derived From GTP

Angewandte Chemie, EarlyView.
The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang, Qingxu Meng, Lingqi Hua, Mengjun Sun, Qianjin Kang, Min‐Juan Xu, Linquan Bai   +6 more
wiley   +2 more sources

Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides

Nature Communications, 2023
Antibiotics are central to modern medicine, and yet they are mainly the products of intra and inter-kingdom evolutionary warfare. To understand how nature evolves antibiotics around a common mechanism of action, we investigated the origins of an ...
Mathias H. Hansen, Martina Adamek, Dumitrita Iftime, Daniel Petras, Frauke Schuseil, Stephanie Grond, Evi Stegmann, Max J. Cryle, Nadine Ziemert   +8 more
doaj   +1 more source

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Structure, Function and Engineering of the Nonribosomal Peptide Synthetase Condensation Domain. [PDF]

Int J Mol Sci
The nonribosomal peptide synthetase (NRPS) is a highly precise molecular assembly machinery for synthesizing structurally diverse peptides, which have broad medicinal applications.
Huang Z, Peng Z, Zhang M, Li X, Qiu X.
europepmc   +2 more sources