Results 61 to 70 of about 8,920 (137)

Predicting Functional Diversity Within Enzyme Families: A Practical Perspective

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
Integrating machine learning into enzyme discovery requires navigating the trade‐offs between data quantity and quality. This article provides a best‐practice framework for developing robust predictors, focusing on mitigating bias in biochemical datasets, implementing systematic “cold‐drug” validation strategies, and utilizing explainable artificial ...
Nika Sokolova, Kristina Haslinger
wiley   +1 more source

Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils.

PLoS ONE, 2017
Aspergillus hancockii sp. nov., classified in Aspergillus subgenus Circumdati section Flavi, was originally isolated from soil in peanut fields near Kumbia, in the South Burnett region of southeast Queensland, Australia, and has since been found ...
John I Pitt, Lene Lange, Alastair E Lacey, Daniel Vuong, David J Midgley, Paul Greenfield, Mark I Bradbury, Ernest Lacey, Peter K Busk, Bo Pilgaard, Yit-Heng Chooi, Andrew M Piggott   +11 more
doaj   +1 more source

Draft genome sequence of a human-associated isolate of Haloferax alexandrinus strain Arc-hr, an extremely halophilic archaea

New Microbes and New Infections, 2017
We report the draft genome sequence of Haloferax alexandrinus strain Arc-hr (CSUR P798), isolated from the human gut of a 10-year-old Amazonian individual. Its 3 893 626 bp genome exhibits a 66.00% GC content.
S. Khelaifia, A. Caputo, F. Djossou, D. Raoult   +3 more
doaj   +1 more source

Verrucacrylic Acids A and B From a Marine Sponge‐derived Verrucosispora sp. FIM06025

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Three new compounds, including two rare cyclopropane‐containing compounds, verrucacrylic acids A and B (1 and 2), and a new amino acid derivative (3), were isolated from Verrucosispora sp. FIM06025, 1 and 2 exhibited weak cytotoxic activity against HL‐60 and T47D. ABSTRACT Verrucosispora sp.
Minghong Chen, Chengzeng Zhou, Ru Lin, Yuan Yuan, Jian Zhou   +4 more
wiley   +1 more source

Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.

PLoS Pathogens, 2007
Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen.
Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas   +9 more
doaj   +1 more source

Actinomycin Analogs From Streptomyces polyantibioticus S4D258: Structural Elucidation and Antiproliferative Activity Against Triple‐Negative Breast Cancer

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Fifteen new actinomycin analogs, named actinomycins H1–H15, are identified from S. polyantibioticus S4D258. Actinomycins H7–H15 are truncated actinomycin analogs. Actinomycins H1–H6 and H9 exhibit significant antiproliferative activities against both MDA‐MB‐231 and 4T1 TNBC cells.
He Pang, Xiao‐Min Huang, Usama Ramadan Abdelmohsen, Li Shen, Jun Wu   +4 more
wiley   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Bacillaceae Within Galium aparine L.: A Plant‐Associated Treasure of Biosynthetic Diversity and Growth‐Promoting Potential

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
The study involved 10 strains of endophytic bacteria isolated for the first time from G. aparine L., including two putatively novel strains from Bacillus and Priestia spp. Bioactivity screening revealed production of a plethora of industrially‐relevant compounds and possible use of those bacteria as biostimulants.
Natalia Rutkowska, Piotr Drożdżyński, Tomasz Boruta, Bartosz Sekuła, Olga Marchut‐Mikołajczyk   +4 more
wiley   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, Volume 293, Issue 20, Page 6022-6037, October 2026.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus

Small Structures
The biosynthesis of pseurotin A, a fungal metabolite with antibiotic and immunosuppressive properties, involves a group of enzymes, including a polyketide‐nonribosomal peptide synthase (PKS‐NRPS), PsoA, and a bifunctional enzyme, PsoF. PsoA consists of a
Lei Sun, Zi‐Long You, Rui‐Qing Lyu, Zhao‐Bin Wang, Ming Ma, Lin Bai   +5 more
doaj   +1 more source