Results 121 to 130 of about 484,644 (166)
, 2016 Nonribosomal peptide synthetases are large, complex multidomain enzymes responsible for the biosynthesis of a wide range of peptidic natural products. Inherent to synthetase chemistry is the thioester templated mechanism that relies on protein/protein ...
Naga Sandhya Guntaka (2852846) +3 more
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Structural and functional characterization of the triplet acyl carrier protein in the curacin cluster and its interaction partners [PDF]
, 2012 According to the World Health Organization (WHO) bacterial resistance to antibiotic drug therapy is emerging as a major public health problem around the world. Infectious diseases seriously threaten the health and economy of all countries.
Busche, Alena (Dr.)
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Nonribosomal peptide synthetases
, 2018 Nonribosomal peptide synthetases or NRPS, are extraordinarily large, modular and complex molecular machines responsible for the production of important bioactive compounds, such as antibiotics, anti-cancer drugs as well as pigments, among many others. Even though it has become increasingly simple to identify and partially classify this kind of enzyme ...
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Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases
Nonribosomal cyclic peptides (NRcPs) are structurally complex natural products and a vital pool of therapeutics, particularly antibiotics. Their structural diversity arises from the ability of the multidomain enzyme assembly lines, nonribosomal peptide ...
Ding, Yao +10 more
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Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases
Bacterial biosynthetic assembly lines, such as nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), play a crucial role in the synthesis of natural products that have significant therapeutic potential.
Kenan A. J. Bozhueyuek (16716446) +3 more
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PARAS: high-accuracy machine-learning of substrate specificities in nonribosomal peptide synthetases
International audienceNonribosomal peptides are chemically and functionally diverse natural products with important applications in medicine and agriculture.
Huang, Chuan +16 more
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Peptide Bond Formation in Nonribosomal Peptide Biosynthesis [PDF]
Journal of Biological Chemistry, 1998 Torsten Stachelhaus +3 more
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, 2009 Nonribosomal peptides are a diverse group of compounds synthesized via modular nonribosomal peptide synthetase (NRPS) enzyme complexes. They are produced by a variety of prokaryotes, including streptomycetes, bacillus, and cyanobacteria, and lower-order eukaryotes such as fungi and sponges.
Roberts, Alexandra A. +2 more
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