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Chapter 14 Biosynthesis of Nonribosomal Peptide Precursors
, 2009 Nonribosomal peptides are natural products typically of bacterial and fungal origin. These highly complex molecules display a broad spectrum of biological activities, and have been exploited for the development of immunosuppressant, antibiotic ...
Wilkinson, Barrie +3 more
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Automated genome mining for natural products
BMC Bioinformatics, 2009 Background Discovery of new medicinal agents from natural sources has largely been an adventitious process based on screening of plant and microbial extracts combined with bioassay-guided identification and natural product structure elucidation ...
Zajkowski James +4 more
doaj +1 more source
Taxonomic Positions of a Nyuzenamide-Producer and Its Closely Related Strains
Microorganisms, 2022 Streptomyces sp. N11-34 is a producer of bicyclic peptides named nyuzenamides A and B. We elucidated its taxonomic position and surveyed its nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) gene clusters by whole genome analysis ...
Hisayuki Komaki +2 more
doaj +1 more source
Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases
, 2018 Nonribosomal peptide antibiotics, including polymyxin, vancomycin, and teixobactin, most of which contain d-amino acids, are highly effective against multidrug-resistant bacteria.
Zhong, Zheng +9 more
core +1 more source
Mechanistic analysis of nonribosomal peptide synthetases [PDF]
, 2021 Considering the ongoing rise of the multidrug-resistant bacterial infections, it is essential to expand the available repertoire of therapeutic agents.
Stanišić, Aleksa
core
Hydrobiology, 2023 Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin and cyclo(Phe-Leu).
Hisayuki Komaki +2 more
doaj +1 more source
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2013 The third part of the review is concerned with investigation of nonribosomal peptides.
T. I. Orlova +2 more
openaire +2 more sources
Nature Communications, 2019 NocTE is a nonribosomal peptide synthetase thioesterase that completes the biosynthesis of pro-nocardicin G, the precursor for nocardicin β-lactam antibiotics. Here the authors provide mechanistic insights into NocTE by determining its crystal structures
Ketan D. Patel +5 more
doaj +1 more source
Norine: A powerful resource for novel nonribosomal peptide discovery
Synthetic and Systems Biotechnology, 2016 Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://
M. Pupin +5 more
doaj +1 more source
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery
Nature Communications, 2021 Current genome mining methods predict many putative non-ribosomal peptides (NRPs) from their corresponding biosynthetic gene clusters, but it remains unclear which of those exist in nature and how to identify their post-assembly modifications.
Bahar Behsaz +15 more
doaj +1 more source