Results 111 to 120 of about 526,871 (218)

Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains

Current Research in Structural Biology, 2020
The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be less ...
Kemin Tan, Min Zhou, Robert P. Jedrzejczak, Ruiying Wu, Raul A. Higuera, Dominika Borek, Gyorgy Babnigg, Andrzej Joachimiak   +7 more
doaj   +1 more source

Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases

, 2016
Nonribosomal peptide synthetases are large, complex multidomain enzymes responsible for the biosynthesis of a wide range of peptidic natural products. Inherent to synthetase chemistry is the thioester templated mechanism that relies on protein/protein ...
Naga Sandhya Guntaka (2852846), Wei-Hung Chen (693540), Kunhua Li (1576657), Steven D. Bruner (1576660)   +3 more
core   +1 more source

Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi [PDF]

, 2016
Filamentous fungi are historically known as rich sources for production of biologically active natural products, so-called secondary metabolites. One particularly pharmaceutically relevant chemical group of secondary metabolites is the nonribosomal peptides synthesized by nonribosomal peptide synthetases (NRPSs).
Alexandra A, Soukup, Nancy P, Keller, Philipp, Wiemann   +2 more
openaire   +2 more sources

On the Evolution of Nonribosomal Peptide Synthetase Gene Clusters in Cyanobacteria [PDF]

, 2007
Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins.
Tooming-Klunderud, Ave
core  

Revealing the Inter-Module Interactions of Multi-Modular Nonribosomal Peptide Synthetases

, 2017
Nonribosomal peptide synthetase (NRPS) enzymes are large modular proteins involved in the biosynthesis of many important pharmaceuticals such as penicillin and cyclosporin. In this issue of Structure, Tarry et al.
J. Shaun Lott, T. Verne Lee, Lott, J Shaun, Lee, T Verne   +3 more
core   +1 more source

Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker's yeast [PDF]

, 2017
Fungi are a valuable source of enzymatic diversity and therapeutic natural products including antibiotics. Here we engineer the baker’s yeast Saccharomyces cerevisiae to produce and secrete the antibiotic penicillin, a beta-lactam nonribosomal peptide ...
Ali R. Awan, Jack C.H. Ho, Shaw, WM, David J. Bell, Blount, Benjamin A., Shaw, William M., Bell, DJ, Ellis, T, Ho, Jack C.H., Bell, David J., Awan, AR, Ho, JCH, Benjamin A. Blount, McKiernan, Robert M., Robert M. McKiernan, Awan, Ali R., William M. Shaw, Tom Ellis, Blount, BA, McKiernan, RM, Ellis, Tom   +20 more
core   +1 more source

Macrolactonization catalyzed by the terminal thioesterase domain of the nonribosomal peptide synthetase responsible for lichenysin biosynthesis

, 2005
The excised terminal thioesterase of the lichenysin nonribosomal peptide synthetase was found to be a highly efficient and versatile enzyme. Its activity strictly requires the R configuration of the β-hydroxy fatty acid and the side chains of aspartate-5
Yang, Yanzhen, Cao, Shuyong, Guo, Zhihong, Ng, Na Lee Joyce   +3 more
core   +1 more source

Cell-free protein synthesis for nonribosomal peptide synthetic biology

Frontiers in Natural Products
Peptide natural products have a wide range of useful applications as pesticides, veterinary agents, pharmaceuticals, and bioproducts. To discover new natural products, manipulate them for analog generation, and to harness the potential of these bioactive
Tien T. Sword, Ghaeath S. K. Abbas, Constance B. Bailey   +2 more
doaj   +1 more source

Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis

, 2008
Nonribosomal enterobactin synthetase of Escherichia coli was found to prematurely release a large amount of linear precursors in an in vitro reconstitution.
Zheng, Suilan, Guo, Zhihong, Jiang, Ming, Guo, Zu Feng   +3 more
core   +1 more source

Suppression of Linear Side Products by Macromolecular Crowding in Nonribosomal Enterobactin Biosynthesis

, 2016
Nonribosomal enterobactin synthetase of Escherichia coli was found to prematurely release a large amount of linear precursors in an in vitro reconstitution.
Ming Jiang (11433), Zhihong Guo (404198), Zu-Feng Guo (2185165), Suilan Zheng (2389246)   +3 more
core   +1 more source