Results 111 to 120 of about 2,306,587 (203)
Trying to make sense in nonsense-mediated mRNA decay
, 2014 Despite over 30 years of research, the molecular mechanisms of nonsense-mediated mRNA decay (NMD) are still not well understood. NMD appears to exist in most eukaryotes and is intensively studied in S. cerevisiae, C. elegans, D.
Zünd, David
core
Investigation of the role of PNRC2 in nonsense-mediated mRNA decay in human cells
, 2016 Nonsense-mediated mRNA decay (NMD) is best known as a eukaryotic surveillance mechanism that targets mRNAs containing premature termination codons (PTCs) for degradation.
Colombo, Martino +3 more
core
Nonsense-mediated mRNA decay among coagulation factor genes [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors.
Shirin Shahbazi
doaj
Determining if an mRNA is a Substrate of Nonsense-Mediated mRNA Decay in Saccharomyces cerevisiae
, 2016 Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic quality control mechanism which triggers decay of mRNAs harboring premature translation termination codons.
Johansson, Marcus J O, +1 more
core +1 more source
Poljoprivreda, 2008 In eukaryotic cell, various quality control mechanisms have evolved to ensure that only perfect mRNAs could be translated. Nonsense-mediated mRNA decay (NMD) is a quality control system that identifies and eliminates mRNAs containing premature termination codons, thereby preventing the accumulation of potentially harmful truncated proteins.
D. Silhavy +4 more
openaire +1 more source
Autoregulation of the nonsense-mediated mRNA decay pathway in human cells
, 2011 Nonsense-mediated mRNA decay (NMD) is traditionally portrayed as a quality-control mechanism that degrades mRNAs with truncated open reading frames (ORFs).
Yepiskoposyan, Hasmik +14 more
core +1 more source
Nonsense‐mediated mRNA decay in Caenorhabditis elegans
, 2008 The nonsense[hyphen (true graphic)]mediated mRNA decay (NMD) pathway is a surveillance mechanism that targets the degradation of mRNAs harboring premature termination codons (PTCs).
Longman, D. +7 more
core +1 more source
Nonsense-mediated mRNA decay (NMD)-based gene regulation [PDF]
Science-Business eXchange, 2008 openaire +1 more source
About one third of all genetic diseases and many forms of cancer are caused by nonsense or frameshift mutations that introduce premature translation-termination codons (PTCs) (1,2). Indeed, PTCs contribute significantly to the spectrum of inherited human
Romão, Luísa
core
Widespread predicted nonsense-mediated mRNA decay of . . .
, 2003 We have recently shown that a third of reliably-inferred alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance system (Lewis et al., 2003, Proc. Natl Acad. Sci. USA, 100, 189--192).
Richard E. Green +7 more
core