Results 111 to 120 of about 17,359 (221)
TDP43 and hnRNP K Regulate Alternative Splicing of DNAJC5
Cell Biology International, Volume 50, Issue 4, April 2026.ABSTRACT Alternative splicing is a finely regulated process which defines the final maturation of pre‐mRNAs. Modulation of trans‐acting spliceosome proteins changes specific patterns of splicing and contributes to the development of diseases. During Amyotrophic Lateral Sclerosis (ALS) disease progression, loss of nuclear trans‐acting splicing protein ...
Helder Y. Nagasse +2 more
wiley +1 more source
Control of gene expression through the nonsense-mediated RNA decay pathway
Cell & Bioscience, 2017 Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells.
Andrew Nickless +2 more
doaj +1 more source
Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay.
Frontiers in Molecular Biosciences, 2014 The nonsense-mediated mRNA decay (NMD) pathway is a specialized pathway that triggers the rapid degradation of select mRNAs. Initially identified as a pathway that degrades mRNAs with premature termination codons, NMD is now recognized as a pathway that ...
Bessie Wanja Kebaara +3 more
doaj +1 more source
Protecting the proteome: Eukaryotic cotranslational quality control pathways. [PDF]
, 2014 The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on
Bennett, Eric J, Lykke-Andersen, Jens
core +2 more sources
Physiological role and quantitative aspects of human Nonsense-mediated mRNA decay (NMD)
, 2007 Nonsense-mediated mRNA decay (NMD) is a molecular pathway of mRNA surveillance that ensures the rapid degradation of mRNAs containing premature translation termination codons in all studied eukaryotes. Originally, NMD was thought of as a quality control pathway that targets non-functional mRNAs arising from mutations and splicing errors. More recently,
openaire +2 more sources
Rescue of nonsense mutations by amlexanox in human cells
Orphanet Journal of Rare Diseases, 2012 Background Nonsense mutations are at the origin of many cancers and inherited genetic diseases. The consequence of nonsense mutations is often the absence of mutant gene expression due to the activation of an mRNA surveillance mechanism called nonsense ...
Gonzalez-Hilarion Sara +9 more
doaj +1 more source
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD [PDF]
, 2017 Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD substrates can be degraded by different routes that all require phosphorylated UPF1 (P-UPF1) as a starting ...
Josi, Christoph +4 more
core
A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans [PDF]
, 2017 Ionizing radiation (IR) is commonly used in cancer therapy and is a main source of DNA double-strand breaks (DSBs), one of the most toxic forms of DNA damage. We have used Caenorhabditis elegans as an invertebrate model to identify novel factors required
Gartner, Anton +2 more
core +3 more sources
Nonsense Suppression as an Approach to Treat Lysosomal Storage Diseases
Diseases, 2016 In-frame premature termination codons (PTCs) (also referred to as nonsense mutations) comprise ~10% of all disease-associated gene lesions. PTCs reduce gene expression in two ways.
Kim M. Keeling
doaj +1 more source