Results 131 to 140 of about 17,359 (221)

MECHANISM AND REGULATION OF NONSENSE-MEDIATED MRNA DECAY (NMD), AN ESSENTIAL QUALITY CONTROL SYSTEM OF PLANTS

open access: yesPoljoprivreda, 2008
In eukaryotic cell, various quality control mechanisms have evolved to ensure that only perfect mRNAs could be translated. Nonsense-mediated mRNA decay (NMD) is a quality control system that identifies and eliminates mRNAs containing premature termination codons, thereby preventing the accumulation of potentially harmful truncated proteins.
D. Silhavy   +4 more
openaire   +1 more source

Impact of protein-protein interactions and phosphorylation on RNA decapping for nonsense mediated mRNA decay (NMD)

open access: yes, 2022
Chez Saccharomyces cerevisiae, la voie de dégradation majoritaire des ARN messagers passe par le clivage de la liaison pyrophosphate entre l’ARNm et la structure de la coiffe à l’extrémité 5’. Cette étape, importante pour la dégradation de l’ensemble des ARNm, est particulièrement clé dans la dégradation d’une classe d’ARN instables, cibles de la voie ...
openaire   +1 more source

p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells [PDF]

open access: yes, 2017
Cheruiyot, Abigael   +5 more
core   +2 more sources

The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts [PDF]

open access: yes, 2014
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC).
Romão, Luísa
core  

The involvement and role of the protein kinase AKT1 in the Nonsense-mediated mRNA decay (NMD)

open access: yes, 2021
La protéine AKT1, appelée aussi protéine kinase B ou PKB, est un composant central de la voie de signalisation PI3K/AKT/mTOR qui représente une des voies majoritaires des cellules régulant un nombre varié de processus biologiques tels que la prolifération cellulaire, l’apoptose, la survie cellulaire ainsi que l’angiogenèse parmi d’autres.
openaire   +1 more source

Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. [PDF]

open access: yes, 2017
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis ...
Atanasova, Velina S.   +10 more
core   +1 more source

Identification of an Alternative Exon in a GABA Receptor Gene [PDF]

open access: yes, 2018
The central dogma of biology states that DNA is transcribed into mRNA, which is then translated into proteins. In order for translation to occur, pre-mRNAs first must be processed.
Apgar, Shannon, Toro, Cecilia P.
core   +1 more source

Funktionelle Charakterisierung der potenziellen Rolle des „Nonsense-mediated mRNA Decay“ (NMD)-Proteins „Up-Frameshift 1“ (UPF1) in der Translation

open access: yes, 2011
„Nonsense-Mediated mRNA Decay“ (NMD) ist ein translationsabhangiger Qualitatskontroll-mechanismus der post-transkriptionalen Genexpression in Eukaryonten. Durch NMD werden mRNAs mit vorzeitigen Stopkodons im offenen Leserahmen (ORF) erkannt und abgebaut, was durch die NMD-Effektorproteine UPF1, UPF2 und UPF3b vermittelt wird.
openaire   +2 more sources

L'implication et le rôle de la protéine kinase AKT1 dans le mécanisme de Nonsense-mediated mRNA decay (NMD)

open access: yes, 2021
La protéine AKT1, appelée aussi protéine kinase B ou PKB, est un composant central de la voie de signalisation PI3K/AKT/mTOR qui représente une des voies majoritaires des cellules régulant un nombre varié de processus biologiques tels que la prolifération cellulaire, l’apoptose, la survie cellulaire ainsi que l’angiogenèse parmi d’autres.
openaire   +1 more source

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