Results 121 to 130 of about 13,111 (197)

Dendritic cell function in the setting of chronic hepatitis c infection and changes during antiviral treatment

, 2009
The role of the innate immune system and in particular of dendritic cells, in the establishment of chronic hepatitis C has been studied quite extensively over the last few years but controversy remains as to whether a potential virus-induced defect in
Pachiadakis, I.
core  

Nonstructural 5A (NS5A) protein of hepatitis C virus : self-association, membrane anchoring and interactions with antivirals

, 2017
Direct-acting antivirals (DAAs) targeting the nonstructural 5A (NS5A) protein of Hepatitis C virus (HCV) are essential drugs with their exceptional clinical success in actual patients. However, surprisingly, their modes of action (MoA) are still unknown,
Beldar, Serap
core   +1 more source

Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response

, 2001
Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). The HCV nonstructural 5A (NS5A) protein has been implicated in HCV antiviral resistance in many studies.
Heather J. Ezelle, Gretch, David R, Khabar, Khalid S. A, Ezelle, Heather J, David R. Gretch, Khalid S. A. Khabar, Polyak, Stephen J, Denise M. Paschal, Paschal, Denise M, Levy, David E, Mukaida, Naofumi, Stephen J. Polyak, Naofumi Mukaida, David E. Levy, Gilles Duverlie, Glen N. Barber, Barber, Glen N, Duverlie, Gilles   +17 more
core   +1 more source

HIV glycoprotein envelope; nonstructural protein 5A (NS5A); C5A [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation. [PDF]

J Virol, 2018
Schenk C, Meyrath M, Warnken U, Schnölzer M, Mier W, Harak C, Lohmann V.   +6 more
europepmc   +1 more source

Advances in the role of HCV nonstructural protein 5a (NS5A) of 3a genotype in inducing insulin resistance by possible phosphorylation of AKT/PKB. [PDF]

Sci Rep, 2019
Shams F, Rafique S, Zahid S, Munir M, Idrees M, Ilyas M, Husnain T.   +6 more
europepmc   +1 more source

Challenge to overcome: Nonstructural protein 5A-P32 deletion in direct-acting antiviral-based therapy for hepatitis C virus. [PDF]

World J Gastroenterol, 2018
Sato K, Uraoka T.
europepmc   +1 more source

Optimizing choice of oral interferon-free treatment for genotype 1 hepatitis C virus using testing for NS5A resistance: a cost-utility analysis from the perspective of the Italian National Health Service

ClinicoEconomics and Outcomes Research, 2017
Kirsten Y Westerhout,1 Walter Bouwmeester,1 Inge Duchesne,2 Marta Pisini,2 Marjanne A Piena,1 Francesco Damele,3 Beatrice Gueron,2 Maarten Treur,1 Jonathan Belsey4 1Pharmerit BV, Marten Meesweg, Rotterdam, the Netherlands; 2Janssen EMEA, Turnhoutseweg ...
Westerhout KY, Bouwmeester W, Duchesne I, Pisini M, Piena MA, Damele F, Gueron B, Treur M, Belsey J   +8 more
doaj  

Viral interferon antagonists and antiviral drugs

, 2009
For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core  

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication. [PDF]

J Biol Chem, 2019
Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D.   +8 more
europepmc   +1 more source