Results 121 to 130 of about 18,126 (202)

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion [PDF]

, 2014
The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion
Guedan, A, Johnston, SL, Mousnier, A, Pinto, A, Rogers, AV, Solari, R, Swieboda, D, Walton, R   +7 more
core   +2 more sources

Concomitant proton pump inhibitor use does not reduce the efficacy of elbasvir/grazoprevir: A pooled analysis of 1,322 patients with hepatitis C infection

Hepatology Communications, 2017
Concomitant proton pump inhibitor (PPI) use reduces plasma concentrations of certain nonstructural protein 5A inhibitors, which are key components of modern hepatitis C infection (HCV) treatments.
Nancy Reau, Michael N. Robertson, Hwa‐Ping Feng, Luzelena Caro, Wendy W. Yeh, Bach‐Yen T. Nguyen, Janice Wahl, Eliav Barr, Peggy Hwang, Stephanie O. Klopfer   +9 more
doaj   +1 more source

Morphogenesis of Infectious Hepatitis C Virus Particles [PDF]

, 2012
More than 170 million individuals are currently infected with hepatitis C virus (HCV) worldwide and are at continuous risk of developing chronic liver diseases.
Tetsuro Suzuki
core   +1 more source

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

PLoS Pathogens, 2013
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an essential host factor of hepatitis C virus (HCV) replication. PI4KIIIα catalyzes the synthesis of phosphatidylinositol 4-phosphate (PI4P) accumulating in HCV replicating cells due ...
Simon Reiss, Christian Harak, Inés Romero-Brey, Danijela Radujkovic, Rahel Klein, Alessia Ruggieri, Ilka Rebhan, Ralf Bartenschlager, Volker Lohmann   +8 more
doaj   +1 more source

Daclatasvir: potential role in hepatitis C

Drug Design, Development and Therapy, 2013
Choongho Lee College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea  Abstract: Chronic hepatitis C virus (HCV) infection is responsible for the development of liver cirrhosis and hepatocellular carcinoma.
Lee C
doaj  

Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence

Drug Design, Development and Therapy, 2018
Kenichi Morikawa, Akihisa Nakamura, Tomoe Shimazaki, Naoya Sakamoto Department of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan Abstract: Treatments for hepatitis C virus (HCV ...
Morikawa K, Nakamura A, Shimazaki T, Sakamoto N   +3 more
doaj  

Harvest-Time Protein Shocks and Price Adjustment in U.S. Wheat Markets [PDF]

Dynamic relationships among three classes of wheat are investigated using threshold VAR models that incorporate the effects of protein availability. Changes in the stock of protein are found to generate significant responses in the prices of hard red ...
Goodwin, Barry K., Smith, Vincent H.
core   +1 more source

Cellular and Viral Determinants for Hepatitis C Virus Replication

, 2011
The recent discovery of an HCV isolate which replicates in cell culture has opened up opportunities to study the full viral life cycle in vitro. This genotype 2a isolate (JFH-1) and its derivatives are the only ones known to replicate efficiently in cell
Baillie, Andrew James, Baillie, Andrew James   +1 more
core   +1 more source

Elbasvir/Grazoprevir for HCV Infection in Russia: A Randomized Trial

Hepatic Medicine: Evidence and Research, 2020
Konstantin Zhdanov,1 Vasily Isakov,2 Eduard Burnevich,3 Svetlana Kizhlo,4 Igor Bakulin,5 Vadim Pokrovsky,6 Liwen Liang,7 Peggy Hwang,7 Rohit Talwani,7 Barbara A Haber,7 Michael N Robertson7 1Military Medical Academy n.a. S.M. Kirov, St.
Zhdanov K, Isakov V, Burnevich E, Kizhlo S, Bakulin I, Pokrovsky V, Liang L, Hwang P, Talwani R, Haber BA, Robertson MN   +10 more
doaj  

HIV glycoprotein envelope; nonstructural protein 5A (NS5A); C5A [PDF]

Science-Business eXchange, 2008
openaire   +1 more source