Results 121 to 130 of about 3,421,850 (195)

Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains

, 2019
Hepatitis C virus (HCV), a major etiologic agent of transfusion associated hepatitis, is a positive, single-stranded RNA virus and is also known to be implicated in liver cirrhosis and hepatocellular carcinoma.
Jang, SK, Chung, KM, Song, OK
core  

Dendritic cell function in the setting of chronic hepatitis c infection and changes during antiviral treatment [PDF]

, 2009
The role of the innate immune system and in particular of dendritic cells, in the establishment of chronic hepatitis C has been studied quite extensively over the last few years but controversy remains as to whether a potential virus-induced defect in
Pachiadakis, I.
core  

Advances in the role of HCV nonstructural protein 5a (NS5A) of 3a genotype in inducing insulin resistance by possible phosphorylation of AKT/PKB. [PDF]

Sci Rep, 2019
Shams F, Rafique S, Zahid S, Munir M, Idrees M, Ilyas M, Husnain T.   +6 more
europepmc   +1 more source

Challenge to overcome: Nonstructural protein 5A-P32 deletion in direct-acting antiviral-based therapy for hepatitis C virus. [PDF]

World J Gastroenterol, 2018
Sato K, Uraoka T.
europepmc   +1 more source

Nonstructural Protein 5A Impairs DNA Damage Repair: Implications for Hepatitis C Virus-Mediated Hepatocarcinogenesis. [PDF]

J Virol, 2018
Nguyen TTT, Park EM, Lim YS, Hwang SB.
europepmc   +1 more source

Optimizing choice of oral interferon-free treatment for genotype 1 hepatitis C virus using testing for NS5A resistance: a cost-utility analysis from the perspective of the Italian National Health Service

ClinicoEconomics and Outcomes Research, 2017
Kirsten Y Westerhout,1 Walter Bouwmeester,1 Inge Duchesne,2 Marta Pisini,2 Marjanne A Piena,1 Francesco Damele,3 Beatrice Gueron,2 Maarten Treur,1 Jonathan Belsey4 1Pharmerit BV, Marten Meesweg, Rotterdam, the Netherlands; 2Janssen EMEA, Turnhoutseweg ...
Westerhout KY, Bouwmeester W, Duchesne I, Pisini M, Piena MA, Damele F, Gueron B, Treur M, Belsey J   +8 more
doaj  

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication. [PDF]

J Biol Chem, 2019
Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D.   +8 more
europepmc   +1 more source

Functional studies of the group A rotavirus non-structural protein NSP4 [PDF]

NSP4, encoded by rotavirus genome segment 10 has been shown to be a transmembrane, endoplasmic reticulum (ER) specific N-linked glycoprotein. Consistent with its localization to the ER membrane, NSP4 was first shown to have a role in the morphogenesis
Yang, Weiming
core  

Hepatitis c virus nonstructural protein 5A: host cell protein-protein interactions and characterization of phosphorylated residues

, 2017
Hepatitis C virus (HCV) is a hepatotropic pathogen present in approximately 2.8% of the population with 3-4 million new infections every year. Up to 85% of infections progress to a chronic disease associated with development of steatosis, cirrhosis and ...
Chestley, Taeyo
core  

[Effect of hepatitis C virus nonstructural protein 5A and its domains II on hepatocyte gluconeogenesis in mice]. [PDF]

Zhonghua Gan Zang Bing Za Zhi, 2017
Zhang JJ, Liu Q, Qiao L.
europepmc   +1 more source