Results 111 to 120 of about 13,111 (197)

Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins.

PLoS Pathogens, 2015
Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood.
Teymur Kazakov, Feng Yang, Harish N Ramanathan, Andrew Kohlway, Michael S Diamond, Brett D Lindenbach   +5 more
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Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains

, 2019
Hepatitis C virus (HCV), a major etiologic agent of transfusion associated hepatitis, is a positive, single-stranded RNA virus and is also known to be implicated in liver cirrhosis and hepatocellular carcinoma.
Jang, SK, Chung, KM, Song, OK
core  

Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes

, 2013
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is involved in regulating viral replication through its direct interaction with the HCV RNA-dependent RNA polymerase.
Carmouse, Sophie, Higgs, Martin R; id_orcid, Pawlotsky, Jean-Michel, Maqbool, Muhammad Ahmad, Imache, Mohamed R, Lerat, Hervé   +5 more
core   +1 more source

Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence

Drug Design, Development and Therapy, 2018
Kenichi Morikawa, Akihisa Nakamura, Tomoe Shimazaki, Naoya Sakamoto Department of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan Abstract: Treatments for hepatitis C virus (HCV ...
Morikawa K, Nakamura A, Shimazaki T, Sakamoto N   +3 more
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Hepatitis c virus nonstructural protein 5A: host cell protein-protein interactions and characterization of phosphorylated residues

, 2017
Hepatitis C virus (HCV) is a hepatotropic pathogen present in approximately 2.8% of the population with 3-4 million new infections every year. Up to 85% of infections progress to a chronic disease associated with development of steatosis, cirrhosis and ...
Chestley, Taeyo
core  

Hepatitis C Virus Nonstructural 5A Protein Inhibits Lipopolysaccharide-Mediated Apoptosis of Hepatocytes by Decreasing Expression of Toll-Like Receptor 4

, 2011
Background. Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to modulate multiple cellular processes, including apoptosis. The aim of this study was to assess the effects of HCV NS5A on apoptosis induced by Toll-like receptor (TLR ...
Shirasawa, H., Roger, T., Shuang Wu, Imazeki, F., Fumio Imazeki, Keiichi Fujiwara, Nakamoto, S., Wakita, T., Thierry Roger, Shingo Nakamoto, Wu, S., Kengo Saito, Takeshi Tanaka, Takaji Wakita, Makoto Arai, Kanda, T., Tamura, R., Tanaka, T., Tatsuo Kanda, Yokosuka, O., Osamu Yokosuka, Fujiwara, K., Ryo Tamura, Hiroshi Shirasawa, Arai, M., Saito, K.   +25 more
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Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor α-stimulated nuclear factor κB activation

, 2019
The hepatitis C virus nonstructural protein 5A (NS5A) is a multifunctional phosphoprotein that leads to pleiotropic responses, in part by regulating cell growth and cellular signaling pathways.
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Hepatitis C virus quasispecies variability modulates nonstructural protein 5A transcriptional activation, pointing to cellular compartmentalization of virus-host interactions.

, 2004
International audienceHepatitis C virus (HCV) behaves in infected patients as a complex mixture of genetically distinct but closely related variants referred to as a "quasispecies." By using quasispecies analysis strategies, we showed that HCV ...
Lopez-Aguirre, Y., Pellerin, M., Penin, F., Pawlotsky, Jm, Dhumeaux, D.   +4 more
core  

NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virus

, 2006
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a monotopic membrane protein anchored to the membrane by an N-terminal in-plane amphipathic alpha-helix.
Chipot, C., Deleage, G., Sapay, N., Montserret, R., Penin, F., Brass, V., Moradpour, D.   +6 more
core   +1 more source

Elbasvir/Grazoprevir for HCV Infection in Russia: A Randomized Trial

Hepatic Medicine: Evidence and Research, 2020
Konstantin Zhdanov,1 Vasily Isakov,2 Eduard Burnevich,3 Svetlana Kizhlo,4 Igor Bakulin,5 Vadim Pokrovsky,6 Liwen Liang,7 Peggy Hwang,7 Rohit Talwani,7 Barbara A Haber,7 Michael N Robertson7 1Military Medical Academy n.a. S.M. Kirov, St.
Zhdanov K, Isakov V, Burnevich E, Kizhlo S, Bakulin I, Pokrovsky V, Liang L, Hwang P, Talwani R, Haber BA, Robertson MN   +10 more
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