Results 91 to 100 of about 18,126 (202)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Real-life prevalence of resistance-associated variants against non-structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C

Virology Journal, 2017
Background Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the efficacy of DAAs. The aim of this
Jung Hwan Yu, Jung Il Lee, Kwan Sik Lee, Ja Kyung Kim   +3 more
doaj   +1 more source

Rift Valley fever virus structural and nonstructural proteins: recombinant protein expression and immunoreactivity against antisera from sheep [PDF]

, 2013
The Rift Valley fever virus (RVFV) encodes the structural proteins nucleoprotein (N), aminoterminal glycoprotein (Gn), carboxyterminal glycoprotein (Gc), and L protein, 78-kD, and the nonstructural proteins NSm and NSs.
Drolet, Barbara S., Faburay, Bonto, Ma, Wenjun, Madden, Daniel, McVey, D. Scott, Richt, Juergen A., Weingartl, Hana, Wilson, William C., Young, Alan   +8 more
core   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Hepatitis C Virus Nonstructural 5A Protein Inhibits Lipopolysaccharide-Mediated Apoptosis of Hepatocytes by Decreasing Expression of Toll-Like Receptor 4 [PDF]

, 2017
Background. Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to modulate multiple cellular processes, including apoptosis. The aim of this study was to assess the effects of HCV NS5A on apoptosis induced by Toll-like receptor (TLR ...
Arai, Makoto, Fujiwara, Keiichi, Imazeki, Fumio, Kanda, Tatsuo, Nakamoto, Shingo, Roger, Thierry, Saito, Kengo, Shirasawa, Hiroshi, Tamura, Ryo, Tanaka, Takeshi, Wakita, Takaji, Wu, Shuang, Yokosuka, Osamu   +12 more
core  

Involvement of nonstructural protein 5A and lipids on production of hepatitis C virus particles

Uirusu, 2008
A robust system for production of recombinant infectious hepatitis C virus (HCV) has been established in 2005 and classical virological techniques are now able to be applied to the HCV research, especially regarding molecular mechanisms on virion assembly and maturation.
Tetsuro, Suzuki, Takahiro, Masaki, Hideki, Aizaki   +2 more
openaire   +3 more sources

Efficient Rescue of Hepatitis C Virus RNA Replication bytrans-Complementation with Nonstructural Protein 5A [PDF]

Journal of Virology, 2005
ABSTRACTStudies ofHepatitis C virus(HCV) RNA replication have become possible with the development of subgenomic replicons. This system allows the functional analysis of the essential components of the viral replication complex, which so far are poorly defined.
Nicole, Appel, Ulrike, Herian, Ralf, Bartenschlager   +2 more
openaire   +2 more sources

Biodegradable, Breathable, and Skin‐Friendly Solution‐Blown Quercetin Nanofibers for Antiviral Nonwoven Filter

EcoMat, Volume 8, Issue 4, April 2026.
A nanofiber filter of quercetin and poly(ethylene oxide), produced through a solution‐blowing technique, serves as an eco‐friendly, high‐performance alternative for antiviral mask filters. The resulting material combines effective particle filtration with excellent breathability, robust mechanical strength, and rapid biodegradability, while also ...
Dogun Park, Joo‐Hyun Hong, Zijun Li, Yeongtak Son, Yea Jung Choi, Sullim Lee, Hyun‐Woo Kim, Daekyu Choi, Kiyong Kim, Yun Seok Joh, Do‐Kyun Kim, Hee Min Yoo, Ki Hyun Kim, Seongpil An   +13 more
wiley   +1 more source

Geographic Distribution of HCV-GT3 Subtypes and Naturally Occurring Resistance Associated Substitutions

Viruses, 2019
Background: Little is known about the frequency or geographic distributions of naturally occurring resistance-associated substitutions (RASs) in the nonstructural protein 5A (NS5A) domain of hepatitis-C virus (HCV) genotype-3 (GT-3) different subtypes ...
Sabrina Bagaglio, Emanuela Messina, Hamid Hasson, Andrea Galli, Caterina Uberti-Foppa, Giulia Morsica   +5 more
doaj   +1 more source

Expanding the Deceased Donor Pool in Manitoba Using Hepatitis C-Viremic Donors: Program Report

Canadian Journal of Kidney Health and Disease, 2021
Purpose of program: The ongoing shortage of organs for transplant combined with Manitoba having the highest prevalence of end-stage renal disease (ESRD) in Canada has resulted in long wait times on the deceased donor waitlist.
Susan Cuvelier, Paul Van Caeseele, Matthew Kadatz, Kathryn Peterson, Siyao Sun, Nancy Dodd, Kim Werestiuk, Joshua Koulack, Peter Nickerson, Julie Ho   +9 more
doaj   +1 more source