Results 91 to 100 of about 3,421,850 (195)

Organ‐specific ozone and nitrogen legacies strengthen substrate control over litter decomposition

Functional Ecology, Volume 40, Issue 8, Page 2548-2559, August 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Elevated tropospheric ozone (O3) and nitrogen (N) deposition are concurrent atmospheric changes that strongly influence terrestrial carbon cycling, yet their combined effects on below‐ground decomposition remain poorly understood.
Xiaofan Hou, Pin Li, Yuqian Sun, Chenhan Ma, Yushu Tian, Qiannan Lin, Yun Li, Lijuan Yin, Dongmei Zhang   +8 more
wiley   +1 more source

Geographic Distribution of HCV-GT3 Subtypes and Naturally Occurring Resistance Associated Substitutions

Viruses, 2019
Background: Little is known about the frequency or geographic distributions of naturally occurring resistance-associated substitutions (RASs) in the nonstructural protein 5A (NS5A) domain of hepatitis-C virus (HCV) genotype-3 (GT-3) different subtypes ...
Sabrina Bagaglio, Emanuela Messina, Hamid Hasson, Andrea Galli, Caterina Uberti-Foppa, Giulia Morsica   +5 more
doaj   +1 more source

Expanding the Deceased Donor Pool in Manitoba Using Hepatitis C-Viremic Donors: Program Report

Canadian Journal of Kidney Health and Disease, 2021
Purpose of program: The ongoing shortage of organs for transplant combined with Manitoba having the highest prevalence of end-stage renal disease (ESRD) in Canada has resulted in long wait times on the deceased donor waitlist.
Susan Cuvelier, Paul Van Caeseele, Matthew Kadatz, Kathryn Peterson, Siyao Sun, Nancy Dodd, Kim Werestiuk, Joshua Koulack, Peter Nickerson, Julie Ho   +9 more
doaj   +1 more source

Physiological Controls on Carbon Fluxes and Biomass Production in Miscanthus: Insights From a Process‐Based Agroecosystem Model

GCB Bioenergy, Volume 18, Issue 8, August 2026.
Miscanthus productivity is governed by interacting plant processes from phenology and canopy development to carbon assimilation. Data‐constrained simulations reveal that photosynthetic protein allocation sets productivity potential, while electron transport capacity remains a key regulator of additional productivity gains.
Zhongjing Jiang, Kaiyu Guan, Ziyi Li, Robert Grant, Rongzhu Qin, Theodore Hartman, Mengqi Jia, Jingting Zhang, Bin Peng, Emily Heaton, Andy VanLoocke, Carl Bernacchi, Andrew D. B. Leakey, Lang Zhou   +13 more
wiley   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness.

PLoS Pathogens
We previously found that high genome replication fitness of the hepatitis C virus (HCV) was associated with severe disease in immunocompromised patients.
Paul Rothhaar, Thibault Tubiana, Colin Förster, Gabriel Vanegas Arias, Tomke Arand, Noemi Schäfer, Philipp Ralfs, Christian Heuss, Antonio Piras, Andreas Pichlmair, Xavier Hanoulle, Stéphane Bressanelli, Volker Lohmann   +12 more
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, Volume 13, Issue 38, 9 July 2026.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Multiomics Identification and Validation of an Integrin–Extracellular Matrix Network Driving Respiratory Syncytial Virus‐Induced Lung Injury and Repair

MedComm, Volume 7, Issue 7, July 2026.
This graphical abstract depicts the dynamic progression from acute lung inflammation to fibrotic repair following RSV infection. Multiomics analysis uncovers a central regulatory network coordinating key pathways including coagulation, extracellular matrix deposition, integrin signaling, and cytoskeletal reorganization.
Lili Zhou, Hua Guo, Xiaofeng Yu, Yu Ran, Ruiqi Liu, Jiali Zhu, Ran Li, Jie Xu, Leshi Chen, Yongliang Zhu, Long Zhang, Zhenjiang Bai, Fangfang Zhou   +12 more
wiley   +1 more source

Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes

, 2004
Hepatitis C virus (HCV) replicates its genome in a membrane-associated replication complex, composed of viral proteins, replicating RNA and altered cellular membranes.
Hubert E. Blum, R. Gosert, M. J. Evans, D. Moradpour, Z. Yuan, Evans, Matthew J., Blum, Hubert Erich Christoph, Lindenbach, Brett D., Brett D. Lindenbach, Goff, Stephen P., Rice, Charles M., Rainer Gosert, Zhenghong Yuan, C. M. Rice, S. P. Goff, Gosert, Rainer, Charles M. Rice, B. D. Lindenbach, Moradpour, Darius, H. E. Blum, Darius Moradpour, Stephen P. Goff, Matthew J. Evans, Yuan, Zhenghong   +23 more
core   +1 more source

HUMAN CYTOMEGALOVIRUS-SPECIFIC CYTO-TOXIC T-CELLS - RELATIVE FREQUENCY OF STAGE-SPECIFIC CTL RECOGNIZING THE 72-KD IMMEDIATE EARLY PROTEIN AND GLYCOPROTEIN-B EXPRESSED BY RECOMBINANT VACCINIA VIRUSES [PDF]

, 1988
CTL are held to be an important host defense mechanism in persistent herpes-virus infections. We have therefore studied the nature and specificity of human cytomegalovirus (HCMV)-specific CTL in normal persistently infected individuals. This was achieved
J K Hickling, Smith, GL, Sinclair, J, J G Sissons, Borysiewicz, LK, J Sinclair, S Graham, G L Smith, L K Borysiewicz, Hickling, JK, Sissons, JG, M P Cranage, Cranage, MP, Graham, S   +13 more
core   +2 more sources