Results 71 to 80 of about 13,111 (197)

Robustness of high‐throughput prediction of leaf ecophysiological traits using near infrared spectroscopy and poro‐fluorometry

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Water scarcity is a major threat to crop production and quality. Improving drought tolerance through variety selection requires a deeper understanding of plant ecophysiological responses, but large‐scale phenotyping remains a bottleneck. This study assessed the potential of high‐throughput tools (spectroscopy and poro‐fluorometry) to predict ...
Eva Coindre, Romain Boulord, Laurine Chir, Virgilio Freitas, Maxime Ryckewaert, Thomas Laisné, Virginie Bouckenooghe, Maëlle Lis, Llorenç Cabrera‐Bosquet, Agnès Doligez, Thierry Simonneau, Benoît Pallas, Aude Coupel‐Ledru, Vincent Segura   +13 more
wiley   +1 more source

Combination of Sofosbuvir-Ledipasvir and Sofosbuvir- Daclatasvir for Treatment HCV Patients in Indonesia

Jurnal Penyakit Dalam Indonesia, 2023
Introduction. Direct-acting antivirals (DAAs) has been developed for treatment hepatitis C virus (HCV). Therapy of HCV using DAA has shown high sustained virologic response (SVR) and shortening duration of therapy.
Andri Sanityoso Sulaiman, Irsan Hasan, Cosmas Rinaldi Adithya Lesmana, Juferdy Kurniawan, Gita Aprilicia, Yayah Nugroho, Nunuk Tri Wahyuni, Budiman Sujatmika Sulaiman   +7 more
doaj   +1 more source

Impact of Crude Oil Contamination on Green Leafy Vegetables: Nutritional and Health Risk Assessments

Remediation Journal, Volume 36, Issue 2, Spring 2026.
ABSTRACT For decades, crude oil spills have been a serious environmental challenge which have led to the establishment of crude oil remediation intervention values (CRIV) by different national agencies to regulate the release of toxic petroleum hydrocarbons via these spills.
Johnson Oluwaseun Odukoya, Ronnie Lambert, Ruben Sakrabani   +2 more
wiley   +1 more source

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation [PDF]

Molecular and Cellular Biology, 1998
The PKR protein kinase is a critical component of the cellular antiviral and antiproliferative responses induced by interferons. Recent evidence indicates that the nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) can repress PKR function in vivo, possibly allowing HCV to escape the antiviral effects of interferon.
M, Gale, C M, Blakely, B, Kwieciszewski, S L, Tan, M, Dossett, N M, Tang, M J, Korth, S J, Polyak, D R, Gretch, M G, Katze   +9 more
openaire   +2 more sources

Small Signaling Peptides in Sorghum bicolor: Integrating Phylogeny and Gene Expression to Characterize Roles in Stem Development

Plant Direct, Volume 10, Issue 6, June 2026.
ABSTRACT Small signaling peptides (SSPs) are important regulators of plant growth, development, and responses to biotic and abiotic stress, yet their role in the C4 grass Sorghum bicolor is largely uncharacterized. To help fill this knowledge gap, 219 sorghum genes that encode SSPs were identified based on SSP sequences previously identified in ...
Evan Kurtz, Brian McKinley, John Mullet
wiley   +1 more source

Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis.

, 2009
BACKGROUND/AIMS: The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) has been implicated in HCV-induced liver pathogenesis. Wnt/beta-catenin signaling has also been involved in tumorigenesis.
김호근
core   +1 more source

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication [PDF]

Proceedings of the National Academy of Sciences, 2004
The study of the hepatitis C virus (HCV) has been hindered by the lack of in vitro model systems. The recent development of HCV subgenomic RNA replicons has permitted the study of viral RNA replication in cell culture; however, the requirements for efficient replication of replicons in this system are poorly ...
Matthew J, Evans, Charles M, Rice, Stephen P, Goff   +2 more
openaire   +2 more sources

Real-life prevalence of resistance-associated variants against non-structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C

Virology Journal, 2017
Background Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the efficacy of DAAs. The aim of this
Jung Hwan Yu, Jung Il Lee, Kwan Sik Lee, Ja Kyung Kim   +3 more
doaj   +1 more source

The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virus. [PDF]

J Virol, 2010
We have recently demonstrated that human apolipoprotein E (apoE) is required for the infectivity and assembly of hepatitis C virus (HCV) (K. S. Chang, J. Jiang, Z. Cai, and G. Luo, J. Virol. 81:13783-13793, 2007; J. Jiang and G. Luo, J. Virol.
Cun W, Jiang J, Luo G.
europepmc   +2 more sources

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1212-1224, June 2026.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source