Results 51 to 60 of about 3,421,850 (195)

The N-terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonism [PDF]

, 2010
This work is supported by UK MRC and BBRCBunyamwera virus NSs protein is involved in the inhibition of cellular transcription and the interferon (IFN) response, and it interacts with the Med8 component of Mediator.
Van Knippenberg, Ingeborg Christine, Carlton-Smith, C., Carlton-Smith, Charles, Elliott, Richard Michael, van Knippenberg, I., Elliott, R.M.   +5 more
core   +1 more source

Differentiation of Foot-and-Mouth Disease-Infected pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA [PDF]

, 2011
The presence of serum antibodies for nonstructural proteins of the foot-and-mouth disease virus (FMDV) can differentiate FMDV-infected animals from vaccinated animals.
Ming-Hwa JONG, Dekker, A., Wen-Bin CHUNG, Lin, Y.L., Fan LEE, Yeou-Liang LIN, Chen, T.H., Ming-Chang LEE, Chu-Hsiang PAN, Hsiang-Jung TSAI, Aldo DEKKER, Lee, M.C., Tsai, H.J., Tsu-Han CHEN, Chin-Cheng HUANG, Chung, W.B., Pan, C.H., Jong, M.H., Huang, C.C., Lee, F.   +19 more
core   +1 more source

Hepatitis C Virus Nonstructural Protein 5A Contains Potential Transcriptional Activator Domains

Molecules and Cells, 1997
Hepatitis C virus (HCV), a major etiologic agent of transfusion associated hepatitis, is a positive, single-stranded RNA virus and is also known to be implicated in liver cirrhosis and hepatocellular carcinoma. Nonstructural protein 5A (NS5A) of HCV contains acidic and proline-rich amino acids in its carboxy-terminal half.
Chung, KM, Song, OK, Jang, SK
openaire   +2 more sources

Cost-Effectiveness of Testing for NS5A Resistance to Optimize Treatment of Elbasvir/Grazoprevir for Chronic Hepatitis C in China

Frontiers in Pharmacology, 2021
Objectives: Baseline presence of nonstructural protein 5A (NS5A) resistance-associated variants can attenuate the efficacy of new direct-acting antivirals.
Jinyu Liu, Yu Zhang, Bin Wu, Sen Wang, David Bin-Chia Wu, David Bin-Chia Wu, Ruxu You   +6 more
doaj   +1 more source

The multifunctional NS1 protein of influenza A viruses [PDF]

, 2008
The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor that has multiple accessory functions during viral infection.
Hale, Benjamin Geoffrey, Hale, B.G., Ortin, J., Jackson, D., Randall, Richard Edward, Randall, R.E., Jackson, David, Ortin, J   +7 more
core   +2 more sources

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection.

PLoS Pathogens, 2019
Hepatitis C virus (HCV) is a positive-strand RNA virus replicating in a membranous replication organelle composed primarily of double-membrane vesicles (DMVs) having morphological resemblance to autophagosomes.
Jae Seung Lee, Keisuke Tabata, Woan-Ing Twu, Md Shafiqur Rahman, Hee Sun Kim, Jin Bae Yu, Min Hyeok Jee, Ralf Bartenschlager, Sung Key Jang   +8 more
doaj   +1 more source

Active RNA replication of hepatitis C virus downregulates CD81 expression. [PDF]

PLoS ONE, 2013
So far how hepatitis C virus (HCV) replication modulates subsequent virus growth and propagation still remains largely unknown. Here we determine the impact of HCV replication status on the consequential virus growth by comparing normal and high levels ...
Po-Yuan Ke, Steve S-L Chen
doaj   +1 more source

The transient nature of bunyamwera orthobunyavirus NSs protein expression : effects of increased stability of NSs protein on virus replication [PDF]

, 2013
The NSs proteins of bunyaviruses are the viral interferon antagonists, counteracting the host's antiviral response to infection. During high-multiplicity infection of cultured mammalian cells with Bunyamwera orthobunyavirus (BUNV), NSs is rapidly ...
Fragkoudis, R., Rennos Fragkoudis, Richard M Elliott, Ingeborg van Knippenberg, van Knippenberg, I., van Knippenberg, Ingeborg, Fragkoudis, Rennos, Elliott, Richard M., Elliott, R.M.   +8 more
core   +1 more source

Addition of ribavirin to daclatasvir plus asunaprevir for chronic hepatitis C 1b patients with baseline NS5A resistance-associated variants improved response

Journal of the Formosan Medical Association, 2017
Daclatasvir is a nonstructural protein 5A inhibitor with potent activity against hepatitis C virus genotypes 1–6 in vitro, and asunaprevir is a nonstructural protein 3 protease inhibitor with activity against genotypes 1, 4, 5, and 6.
Chun-Ming Hong, Chun-Jen Liu, Shiou-Hwei Yeh, Pei-Jer Chen   +3 more
doaj   +1 more source

Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein [PDF]

, 2012
Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open reading frame of the norovirus RNA genome encodes for a polyprotein that is cleaved by the viral ...
Krause Kurt L., Luckner, Sylvia R., Krause, Kurt L., Luckner Sylvia R., Lambden, Paul R., Sylvia R Luckner, Kurt L Krause, Clarke, Ian N., Paul R Lambden, Baker, Estelle S., Ian N Clarke, Baker Estelle S., Estelle S Baker, Ward Vernon K., Lambden Paul R., Ward, Vernon K., Clarke Ian N., Vernon K Ward   +17 more
core   +1 more source