Results 51 to 60 of about 13,111 (197)
, 2010 The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV), plays a critical role in HCV replication and is an attractive target for the therapy of HCV infection. So far, little is known about the post-translational regulation of NS5A protein and its
Hou, Weihong +3 more
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Active RNA replication of hepatitis C virus downregulates CD81 expression. [PDF]
PLoS ONE, 2013 So far how hepatitis C virus (HCV) replication modulates subsequent virus growth and propagation still remains largely unknown. Here we determine the impact of HCV replication status on the consequential virus growth by comparing normal and high levels ...
Po-Yuan Ke, Steve S-L Chen
doaj +1 more source
Journal of the Formosan Medical Association, 2017 Daclatasvir is a nonstructural protein 5A inhibitor with potent activity against hepatitis C virus genotypes 1–6 in vitro, and asunaprevir is a nonstructural protein 3 protease inhibitor with activity against genotypes 1, 4, 5, and 6.
Chun-Ming Hong +3 more
doaj +1 more source
Hepatitis C Virus Nonstructural Protein 5A Contains Potential Transcriptional Activator Domains
Molecules and Cells, 1997 Hepatitis C virus (HCV), a major etiologic agent of transfusion associated hepatitis, is a positive, single-stranded RNA virus and is also known to be implicated in liver cirrhosis and hepatocellular carcinoma. Nonstructural protein 5A (NS5A) of HCV contains acidic and proline-rich amino acids in its carboxy-terminal half.
Chung, KM, Song, OK, Jang, SK
openaire +2 more sources
PLoS Pathogens, 2014 Widely used chemical genetic screens have greatly facilitated the identification of many antiviral agents. However, the regions of interaction and inhibitory mechanisms of many therapeutic candidates have yet to be elucidated.
Hangfei Qi +17 more
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Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
World Journal of Gastroenterology, 2011 To explore the function of Nonstructural 5A (NS5A) protein of genotype 2a (JFH1) in the replication and infection of hepatitis C virus (HCV).Intergenotypic chimera FL-J6JFH/J4NS5A was constructed by inserting NS5A gene from 1b stain HC-J4 by the overlapping polymerase chain reaction (PCR) method and the restriction enzyme reaction.
Yong-Zhi, Wang +7 more
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Molecules, 2014 HCV-induced CAPN activation and its effects on virus-infected cells in a host-immune system have been studied recently. It has been shown that the HCV-nonstructural 5A protein acts as both an inducer and a substrate for host CAPN protease; it ...
Han-Ha Chai +4 more
doaj +1 more source
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
An integrated analysis of elbasvir/grazoprevir in Korean patients with hepatitis C virus genotype 1b infection [PDF]
Clinical and Molecular Hepatology, 2019 Background/Aims In the Republic of Korea, an estimated 231,000 individuals have chronic hepatitis C virus (HCV) infection. The aim of the present analysis was to evaluate the safety and efficacy of elbasvir/grazoprevir (EBR/GZR) administered for 12 weeks
Youn Jae Lee +11 more
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