Results 51 to 60 of about 18,126 (202)
SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation.
PLoS ONE, 2019 Hepatitis C virus (HCV) replication involves many viral and host factors. Host factor SPRY domain- and SOCS box-containing protein 2(SPSB2) belongs to SPSB family, and it recruits target proteins by the SPRY domain and forms E3 ubiquitin ligase complexes
Mingzhen Wang +10 more
doaj +1 more source
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells
Scientific Reports, 2022 SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum antiviral nucleoside analog.
Xammy Huu Wrynla +22 more
doaj +1 more source
Deep Sequencing Analysis of RNAs from Citrus Plants Grown in a Citrus Sudden Death-Affected Area Reveals Diverse Known and Putative Novel Viruses. [PDF]
, 2017 Citrus sudden death (CSD) has caused the death of approximately four million orange trees in a very important citrus region in Brazil. Although its etiology is still not completely clear, symptoms and distribution of affected plants indicate a viral ...
Coletta-Filho, Helvecio D +7 more
core +3 more sources
Frontiers in Pharmacology, 2021 Objectives: Baseline presence of nonstructural protein 5A (NS5A) resistance-associated variants can attenuate the efficacy of new direct-acting antivirals.
Jinyu Liu +6 more
doaj +1 more source
Regulation of positive-strand RNA virus replication: The emerging role of phosphorylation. [PDF]
, 2007 Protein phosphorylation is a reversible post-translational modification that plays a fundamental role in the regulation of many cellular processes.
Jakubiec, Anna, Jupin, Isabelle
core +3 more sources
RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection.
PLoS Pathogens, 2019 Hepatitis C virus (HCV) is a positive-strand RNA virus replicating in a membranous replication organelle composed primarily of double-membrane vesicles (DMVs) having morphological resemblance to autophagosomes.
Jae Seung Lee +8 more
doaj +1 more source
Active RNA replication of hepatitis C virus downregulates CD81 expression. [PDF]
PLoS ONE, 2013 So far how hepatitis C virus (HCV) replication modulates subsequent virus growth and propagation still remains largely unknown. Here we determine the impact of HCV replication status on the consequential virus growth by comparing normal and high levels ...
Po-Yuan Ke, Steve S-L Chen
doaj +1 more source
Journal of the Formosan Medical Association, 2017 Daclatasvir is a nonstructural protein 5A inhibitor with potent activity against hepatitis C virus genotypes 1–6 in vitro, and asunaprevir is a nonstructural protein 3 protease inhibitor with activity against genotypes 1, 4, 5, and 6.
Chun-Ming Hong +3 more
doaj +1 more source
Virology, 1999 We previously showed that two proteins with molecular weights of 56 and 58 kDa are produced from nonstructural protein 5A (NS5A) derived from hepatitis C virus (HCV)-1b genotype. The 56-kDa protein is phosphorylated at serine residues in NS5A, including those located in the C-terminal region of NS5A, while the 58-kDa protein, the hyperphosphorylated ...
Hirota, Masami +7 more
openaire +2 more sources
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication [PDF]
Proceedings of the National Academy of Sciences, 2004 The study of the hepatitis C virus (HCV) has been hindered by the lack of in vitro model systems. The recent development of HCV subgenomic RNA replicons has permitted the study of viral RNA replication in cell culture; however, the requirements for efficient replication of replicons in this system are poorly ...
Matthew J, Evans +2 more
openaire +2 more sources