Results 31 to 40 of about 13,111 (197)

NMR and circular dichroism data for domain 2 of the HCV NS5A protein phosphorylated by the Casein Kinase II

Data in Brief, 2018
The Hepatitis C Virus (HCV)11 HCV: Hepatitis C Virus; HSQC: heteronuclear single-quantum coherence; NS5A: nonstructural protein 5A; NS5A-D2: domain 2 of the nonstructural protein 5A; CKII: Casein kinase II, NS5A-D2_CKII: NS5A-D2 phosphorylated by CKII ...
Luiza M. Bessa, Robert Schneider, Xavier Hanoulle   +2 more
doaj   +1 more source

Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry [PDF]

Journal of Virology, 2015
ABSTRACT The life cycle of hepatitis C virus (HCV) is highly dependent on host cellular proteins for virus propagation. In order to identify the cellular factors involved in HCV propagation, we performed protein microarray assay using the HCV nonstructural 5A (NS5A) protein as a probe.
Chorong, Park, Saehong, Min, Eun-Mee, Park, Yun-Sook, Lim, Sangmin, Kang, Tetsuro, Suzuki, Eui-Cheol, Shin, Soon B, Hwang   +7 more
openaire   +2 more sources

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

mBio, 2015
Induction of membrane rearrangements in the cytoplasm of infected cells is a hallmark of positive-strand RNA viruses. These altered membranes serve as scaffolds for the assembly of viral replication factories (RFs).
Inés Romero-Brey, Carola Berger, Stephanie Kallis, Androniki Kolovou, David Paul, Volker Lohmann, Ralf Bartenschlager   +6 more
doaj   +1 more source

Lipid metabolism and HCV infection [PDF]

, 2010
Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body.
Boulant, Steeve, Paul Targett-Adams, Targett-Adams, Paul, Douglas, Mark W., McLauchlan, John, Steeve Boulant, John McLauchlan, Mark W. Douglas   +7 more
core   +1 more source

Phytochemical analysis of Berberis lyceum methanolic extract and its antiviral activity through the restoration of MAPK signaling pathway modulated by HCV NS5A

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To evaluate the antiviral activity and phytochemicals of selected plant extracts and their effect on the mitogen-activated protein kinase (MAPK) signaling pathway modulated by hepatitis C virus (HCV) nonstructural protein 5A (NS5A). Methods: A
Koloko Brice Landry, Shafiq Azam, Sidra Rehman, Somayya Tariq, Bushra Iqbal, Mateen Abbas, Dieudonné Massoma Lembè, Bushra Ijaz   +7 more
doaj   +1 more source

Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]

, 2007
Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K, Tamberg, Nele, Merits, Andres, Fazakerley, JK, Fragkoudis, R, Lulla, V, Lulla, Valeria, Lulla, A, Merits, A, Tamberg, N, Fragkoudis, Rennos, Lulla, Aleksei   +11 more
core   +1 more source

Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

Nature Communications, 2016
Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for ...
Nari Kim, Min-Jung Kim, Pil Soo Sung, Yong Chul Bae, Eui-Cheol Shin, Joo-Yeon Yoo   +5 more
doaj   +1 more source

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

Viruses, 2023
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in the viral replication cycle ...
Dandan Liu, Tanya P. Ndongwe, Juan Ji, Andrew D. Huber, Eleftherios Michailidis, Charles M. Rice, Robert Ralston, Philip R. Tedbury, Stefan G. Sarafianos   +8 more
doaj   +1 more source

Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy

Cells, 2019
Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein,
Alagie Jassey, Ching-Hsuan Liu, Chun A. Changou, Christopher D. Richardson, Hsue-Yin Hsu, Liang-Tzung Lin   +5 more
doaj   +1 more source

Cyclophilin Inhibitors as a Novel HCV Therapy

Viruses, 2010
A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence.
Hengli Tang
doaj   +1 more source