Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein [PDF]
Journal of Biological Chemistry, 2005 Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to antagonize numerous cellular pathways, including the antiviral interferon-α response.
Hargittai, M.R.S. +7 more
core +5 more sources
The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts. [PDF]
Nucleic Acids Res, 2018 Numerous mammalian proto-oncogene and other growth-regulatory transcripts are upregulated in malignancy due to abnormal mRNA stabilization. In hepatoma cells expressing a hepatitis C virus (HCV) subgenomic replicon, we found that the viral nonstructural ...
Guo L +8 more
europepmc +3 more sources
Phosphorylation of Nonstructural 5A Protein of Hepatitis C Virus: HCV Group-Specific Hyperphosphorylation [PDF]
Virology, 1999 We previously showed that two proteins with molecular weights of 56 and 58 kDa are produced from nonstructural protein 5A (NS5A) derived from hepatitis C virus (HCV)-1b genotype.
Asabe, Shin-ichi +7 more
core +3 more sources
Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta 3 [PDF]
Journal of Virology, 2019 It has been suggested that nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) plays a role in the incapacitation of interferon by inactivation of RNA-dependent protein kinase PKR.
Hahm, B +8 more
core +4 more sources
PLoS ONE, 2013 Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim +3 more
doaj +4 more sources
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. [PDF]
Journal of Biological Chemistry, 2004 International audienceHepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a membrane-associated, essential component of the viral replication complex.
Brass, V. +8 more
core +7 more sources
Variability of the nonstructural 5A protein of hepatitis C virus type 3a isolates and relation to interferon sensitivity. [PDF]
The Journal of Infectious Diseases, 2002 International audienceThe nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) genotype 1 is thought to interact with several cellular proteins, including the double-stranded RNA-dependent protein kinase (PKR) induced by interferon (IFN).
Capron, D. +9 more
core +5 more sources
PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. [PDF]
J Virol, 2020 PACSIN2 is a lipid-binding protein that triggers the tubulation of the phosphatidic acid-containing membranes. The functional involvement of PACSIN2 in the virus life cycle has not yet been demonstrated. We showed that phosphorylation of PACSIN2 displayed a negative effect on NS5A and core interaction. The most significant finding is that NS5A prevents
Nguyen LP +4 more
europepmc +4 more sources
PLoS Pathogens, 2008 Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world population infected with this virus, the lack of a prophylactic ...
Nicole Appel +8 more
doaj +4 more sources
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A [PDF]
Hepatology, 2011 The interferon-stimulated gene, viperin, has been shown to have antiviral activity against hepatitis C virus (HCV) in the context of the HCVreplicon, although the molecular mechanisms responsible are not well understood. Here, we demonstrate that viperin
Yip, L. +19 more
core +4 more sources