Results 11 to 20 of about 13,111 (197)

Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein [PDF]

Journal of Biological Chemistry, 2005
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to antagonize numerous cellular pathways, including the antiviral interferon-α response.
Hargittai, M.R.S., Arnold, J.J., Raney, K.D., Chen, Y., Cameron, C.E., Huang, L., Sharma, S.D., Hwang, J.   +7 more
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The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts. [PDF]

Nucleic Acids Res, 2018
Numerous mammalian proto-oncogene and other growth-regulatory transcripts are upregulated in malignancy due to abnormal mRNA stabilization. In hepatoma cells expressing a hepatitis C virus (HCV) subgenomic replicon, we found that the viral nonstructural ...
Guo L, Sharma SD, Debes JD, Beisang D, Rattenbacher B, Vlasova-St Louis I, Wiesner DL, Cameron CE, Bohjanen PR.   +8 more
europepmc   +3 more sources

Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta 3 [PDF]

Journal of Virology, 2019
It has been suggested that nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) plays a role in the incapacitation of interferon by inactivation of RNA-dependent protein kinase PKR.
Hahm, B, Seedorf, M, Lee, J, Cho, S, Jang, SK, Kim, JE, Lim, J, Chung, KM, Song, OK   +8 more
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Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. [PDF]

Journal of Biological Chemistry, 2004
International audienceHepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a membrane-associated, essential component of the viral replication complex.
Appel, N., Bartenschlager, R., Moradpour, D., Ramboarina, Stephanie, Penin, F., Blum, Hubert Erich Christoph, Ficheux, Damien, Montserret, R., Brass, V., Appel, Nicole, Moradpour, Darius, Ramboarina, S., Bartenschlager, Ralf, Penin, François, Blum, He, Ficheux, D., Brass, Volker, Blum, H.E., Montserret, Roland   +18 more
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Phosphorylation of Nonstructural 5A Protein of Hepatitis C Virus: HCV Group-Specific Hyperphosphorylation

Virology, 1999
We previously showed that two proteins with molecular weights of 56 and 58 kDa are produced from nonstructural protein 5A (NS5A) derived from hepatitis C virus (HCV)-1b genotype.
Asabe, Shin-ichi, Kohara, Michinori, Shimotohno, Kunitada, Tsukiyama-Kohara, Kyoko, Hijikata, Makoto, Hirota, Masami, Kato, Nobuyuki, Satoh, Shinya   +7 more
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Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation.

PLoS ONE, 2013
Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim, Yun-Sook Lim, Jong-Wook Kim, Soon B Hwang   +3 more
doaj   +4 more sources

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A [PDF]

Hepatology, 2011
The interferon-stimulated gene, viperin, has been shown to have antiviral activity against hepatitis C virus (HCV) in the context of the HCVreplicon, although the molecular mechanisms responsible are not well understood. Here, we demonstrate that viperin
Yip, L., Guillaume Fiches, Kui Li, Rohit K. Jangra, Karla J. Helbig, Nicholas S. Eyre, Evelyn Yip, Jangra, R., Beard, M., Stanley M. Lemon, Eyre, N., Fiches, G., Erin M. McCartney, Li, K., Michael R. Beard, Narayana, S., McCartney, E., Lemon, S., Sumudu Narayana, Helbig, K.   +19 more
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Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. [PDF]

J Virol, 2010
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) exhibits a preference for G/U-rich RNA in vitro . Biological analysis of the NS5A RNA-binding activity and its target sites in the genome will be facilitated by a description
Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, Raney KD, Kao CC, Cameron CE.   +8 more
europepmc   +5 more sources

Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles [PDF]

Hepatology, 2010
Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. Restriction of HCV infection to human hepatocytes suggests that liver-specific host factors play a role in the viral life cycle.
Parnot, Marie, Krieger, Sophie, E., McLauchlan, John, Zeisel, Mirjam, B., Baumert, Thomas, F., Dimitrova, Maria, Lupberger, Joachim, Hildt, Eberhard, Benga, Wagane, J. A., Krieger, Sophie E., Baumert, Thomas F., Luo, Guangxiang, Baumert, Thomas, Benga, Wagane J. A., Zeisel, Mirjam B., Hildt, Eberhardt, Schuster, Catherine   +16 more
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The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile—Part 1

ChemMedChem, 2014
Nonstructural protein 5A (NS5A) represents a novel target for the treatment of hepatitis C virus (HCV). Daclatasvir, recently reported by Bristol–Myers–Squibb, is a potent NS5A inhibitor currently under investigation in phase 3 clinical trials. While the
Dayal, Satish, Milbank, Jared, Nichols, Carly, Florian Wakenhut, David C. Blakemore, Rebecca Glen, Duncan Hay, Michael Paradowski, Rebecca Halstead, Jared Milbank, Wakenhut, Florian, Smith-Burchnell, Caroline, David C. Pryde, Chris Pickford, Fiona Adam, Pryde, David C., Blakemore, David C., Wilson, Craig P., Pike, Andrew, Caroline Smith‐Burchnell, Shaw, Stephen, Stephen Shaw, Adam, Fiona, Andrew Pike, Lesa Watson, Paradowski, Michael, Rebecca A. Brimage, Jean‐Yves Chiva, Tran, Thien Duc, Hay, Duncan, Thien Duc Tran, Rob Webster, Halstead, Rebecca, Chiva, Jean-Yves, Westby, Mike, Mike Westby, Gardner, Iain, Pickford, Chris, Glen, Rebecca, Satish Dayal, Carly Nichols, Brimage, Rebecca A., Webster, Rob, Watson, Lesa, Iain Gardner, Craig P. Wilson   +45 more
core   +3 more sources