Results 41 to 50 of about 3,421,850 (195)

Mitophagy induced by classical swine fever virus nonstructural protein 5A promotes viral replication

Virus Research, 2022
The classical swine fever virus (CSFV) is one of the most harmful pathogens of swine and causes considerable economic loss. Mitophagy is a selective form of autophagy that degrades damaged mitochondria by combining with lysosomes. Previous studies have been reported that CSFV infection can induce mitophagy, but which effector protein is responsible for
Zhang, Chengcheng, Wang, Xiuling, Sun, Jiahao, Guo, Mengjiao, Zhang, Xiaorong, Wu, Yantao   +5 more
openaire   +2 more sources

Lipid metabolism and HCV infection [PDF]

, 2010
Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body.
Boulant, Steeve, Paul Targett-Adams, Targett-Adams, Paul, Douglas, Mark W., McLauchlan, John, Steeve Boulant, John McLauchlan, Mark W. Douglas, Targett-Adams, Douglas, McLauchlan, Boulant   +11 more
core   +1 more source

Involvement of nonstructural protein 5A and lipids on production of hepatitis C virus particles

Uirusu, 2008
A robust system for production of recombinant infectious hepatitis C virus (HCV) has been established in 2005 and classical virological techniques are now able to be applied to the HCV research, especially regarding molecular mechanisms on virion assembly and maturation.
SUZUKI, Tetsuro, MASAKI, Takahiro, AIZAKI, Hideki   +2 more
openaire   +3 more sources

Perilipin 5 alleviates HCV NS5A-induced lipotoxic injuries in liver

Lipids in Health and Disease, 2019
Background The homeostasis of lipid droplets (LDs) plays a crucial role in maintaining the physical metabolic processes in cells, and is regulated by many LD-associated proteins, including perilipin 5 (Plin5) in liver.
Jin Zhang, Xing Gao, Yuan Yuan, Chao Sun, Yuanlin Zhao, Liming Xiao, Ying Yang, Yu Gu, Risheng Yang, Peizhen Hu, Lijun Zhang, Chao Wang, Jing Ye   +12 more
doaj   +1 more source

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

Pharmaceuticals, 2022
In today’s global plan to completely eradicate hepatitis C virus (HCV), the essential list of medications used for HCV treatment are direct-acting antivirals (DAAs), as interferon-sparing regimens have become the standard-of-care (SOC) treatment.
Jehad Hamdy, Nouran Emadeldin, Mostafa M. Hamed, Efseveia Frakolaki, Sotirios Katsamakas, Niki Vassilaki, Grigoris Zoidis, Anna K. H. Hirsch, Mohammad Abdel-Halim, Ashraf H. Abadi   +9 more
doaj   +1 more source

Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. [PDF]

J Virol, 2010
ABSTRACT Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) exhibits a preference for G/U-rich RNA in vitro . Biological analysis of the NS5A RNA-binding activity and its target sites in the genome will be facilitated by a description of the NS5A-RNA complex.
Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, Raney KD, Kao CC, Cameron CE.   +8 more
europepmc   +4 more sources

SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation.

PLoS ONE, 2019
Hepatitis C virus (HCV) replication involves many viral and host factors. Host factor SPRY domain- and SOCS box-containing protein 2(SPSB2) belongs to SPSB family, and it recruits target proteins by the SPRY domain and forms E3 ubiquitin ligase complexes
Mingzhen Wang, Yu Wang, Yuehong Liu, Hailong Wang, Xiu Xin, Jiadai Li, Yao Hao, Lingling Han, Fang Yu, Congyi Zheng, Chao Shen   +10 more
doaj   +1 more source

Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]

, 2007
Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K, Tamberg, Nele, Merits, Andres, Fazakerley, JK, Fragkoudis, R, Lulla, V, Lulla, Valeria, Lulla, A, Merits, A, Tamberg, N, Fragkoudis, Rennos, Lulla, Aleksei   +11 more
core   +1 more source

A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection [PDF]

, 1988
The nonstructural immediate-early protein pp89 of murine cytomegalovirus (MCMV) is the first viral protein synthesized after infection and has a regulatory function in viral gene expression. Despite its localization in the nucleus of infected cells, pp89
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Keil, Günther M., Jonjic, Stipan   +4 more
core   +1 more source

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

Scientific Reports, 2022
SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum antiviral nucleoside analog.
Xammy Huu Wrynla, Eddie Wehri, Erik Van Dis, Scott B. Biering, Livia H. Yamashiro, Chi Zhu, Julien Stroumza, Claire Dugast-Darzacq, Thomas G. W. Graham, Xuanting Wang, Steffen Jockusch, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, James J. Russo, Jingyue Ju, Anders M. Näär, Sarah Stanley, Julia Schaletzky   +22 more
doaj   +1 more source