Results 41 to 50 of about 13,111 (197)

Involvement of nonstructural protein 5A and lipids on production of hepatitis C virus particles

Uirusu, 2008
A robust system for production of recombinant infectious hepatitis C virus (HCV) has been established in 2005 and classical virological techniques are now able to be applied to the HCV research, especially regarding molecular mechanisms on virion assembly and maturation.
SUZUKI, Tetsuro, MASAKI, Takahiro, AIZAKI, Hideki   +2 more
openaire   +3 more sources

Mitophagy induced by classical swine fever virus nonstructural protein 5A promotes viral replication

Virus Research, 2022
The classical swine fever virus (CSFV) is one of the most harmful pathogens of swine and causes considerable economic loss. Mitophagy is a selective form of autophagy that degrades damaged mitochondria by combining with lysosomes. Previous studies have been reported that CSFV infection can induce mitophagy, but which effector protein is responsible for
Zhang, Chengcheng, Wang, Xiuling, Sun, Jiahao, Guo, Mengjiao, Zhang, Xiaorong, Wu, Yantao   +5 more
openaire   +2 more sources

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

Pharmaceuticals, 2022
In today’s global plan to completely eradicate hepatitis C virus (HCV), the essential list of medications used for HCV treatment are direct-acting antivirals (DAAs), as interferon-sparing regimens have become the standard-of-care (SOC) treatment.
Jehad Hamdy, Nouran Emadeldin, Mostafa M. Hamed, Efseveia Frakolaki, Sotirios Katsamakas, Niki Vassilaki, Grigoris Zoidis, Anna K. H. Hirsch, Mohammad Abdel-Halim, Ashraf H. Abadi   +9 more
doaj   +1 more source

Perilipin 5 alleviates HCV NS5A-induced lipotoxic injuries in liver

Lipids in Health and Disease, 2019
Background The homeostasis of lipid droplets (LDs) plays a crucial role in maintaining the physical metabolic processes in cells, and is regulated by many LD-associated proteins, including perilipin 5 (Plin5) in liver.
Jin Zhang, Xing Gao, Yuan Yuan, Chao Sun, Yuanlin Zhao, Liming Xiao, Ying Yang, Yu Gu, Risheng Yang, Peizhen Hu, Lijun Zhang, Chao Wang, Jing Ye   +12 more
doaj   +1 more source

SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation.

PLoS ONE, 2019
Hepatitis C virus (HCV) replication involves many viral and host factors. Host factor SPRY domain- and SOCS box-containing protein 2(SPSB2) belongs to SPSB family, and it recruits target proteins by the SPRY domain and forms E3 ubiquitin ligase complexes
Mingzhen Wang, Yu Wang, Yuehong Liu, Hailong Wang, Xiu Xin, Jiadai Li, Yao Hao, Lingling Han, Fang Yu, Congyi Zheng, Chao Shen   +10 more
doaj   +1 more source

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

Scientific Reports, 2022
SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum antiviral nucleoside analog.
Xammy Huu Wrynla, Eddie Wehri, Erik Van Dis, Scott B. Biering, Livia H. Yamashiro, Chi Zhu, Julien Stroumza, Claire Dugast-Darzacq, Thomas G. W. Graham, Xuanting Wang, Steffen Jockusch, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, James J. Russo, Jingyue Ju, Anders M. Näär, Sarah Stanley, Julia Schaletzky   +22 more
doaj   +1 more source

Cost-Effectiveness of Testing for NS5A Resistance to Optimize Treatment of Elbasvir/Grazoprevir for Chronic Hepatitis C in China

Frontiers in Pharmacology, 2021
Objectives: Baseline presence of nonstructural protein 5A (NS5A) resistance-associated variants can attenuate the efficacy of new direct-acting antivirals.
Jinyu Liu, Yu Zhang, Bin Wu, Sen Wang, David Bin-Chia Wu, David Bin-Chia Wu, Ruxu You   +6 more
doaj   +1 more source

NS5ATP9 contributes to inhibition of cell proliferation by hepatitis C virus (HCV) nonstructural protein 5A (NS5A) via MEK/extracellular signal regulated kinase (ERK) pathway. [PDF]

Int J Mol Sci, 2013
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a remarkable protein as it clearly plays multiple roles in mediating viral replication, host-cell interactions and viral pathogenesis.
Wang Q, Wang Y, Li Y, Gao X, Liu S, Cheng J.   +5 more
europepmc   +2 more sources

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection.

PLoS Pathogens, 2019
Hepatitis C virus (HCV) is a positive-strand RNA virus replicating in a membranous replication organelle composed primarily of double-membrane vesicles (DMVs) having morphological resemblance to autophagosomes.
Jae Seung Lee, Keisuke Tabata, Woan-Ing Twu, Md Shafiqur Rahman, Hee Sun Kim, Jin Bae Yu, Min Hyeok Jee, Ralf Bartenschlager, Sung Key Jang   +8 more
doaj   +1 more source

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A., Boyd, A, Fazakerley, John K., Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, J. K. Fazakerley, Elliott, Richard M, Boyd, Amanda, H. Streitenfeld, Elliott, R.M., Streitenfeld, H., A. Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J K, Fazakerley, J.K., F. Weber, R. M. Elliott, Bridgen, A, Elliott, Richard Michael, Bridgen, Anne, A. Boyd   +25 more
core   +1 more source