Results 61 to 70 of about 3,421,850 (195)

A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity.

PLoS Pathogens, 2014
Widely used chemical genetic screens have greatly facilitated the identification of many antiviral agents. However, the regions of interaction and inhibitory mechanisms of many therapeutic candidates have yet to be elucidated.
Hangfei Qi, C Anders Olson, Nicholas C Wu, Ruian Ke, Claude Loverdo, Virginia Chu, Shawna Truong, Roland Remenyi, Zugen Chen, Yushen Du, Sheng-Yao Su, Laith Q Al-Mawsawi, Ting-Ting Wu, Shu-Hua Chen, Chung-Yen Lin, Weidong Zhong, James O Lloyd-Smith, Ren Sun   +17 more
doaj   +1 more source

Effects of Atmospheric CO2 Levels on the Susceptibility of Maize to Diverse Pathogens

Plant, Cell &Environment, EarlyView.
ABSTRACT Rising atmospheric CO2 has significant implications for crop productivity and food security. Based on studies in C3 plants, elevated CO2 (eCO2) can shape plant‐pathogen interactions, although the outcomes are often variable. The question of how eCO2 influences immunity and disease development in C4 plants, such as the globally important cereal
Ekkachai Khwanbua, Yunhui Qi, John Ssengo, Peng Liu, Michelle A. Graham, Steven A. Whitham   +5 more
wiley   +1 more source

Apolipoprotein E Interacts With Hepatitis C Virus Nonstructural Protein 5A and Determines Assembly of Infectious Particles [PDF]

Hepatology, 2010
Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. Restriction of HCV infection to human hepatocytes suggests that liver-specific host factors play a role in the viral life cycle.
Benga, Wagane, Krieger, Sophie, Dimitrova, Maria, Zeisel, Mirjam, Parnot, Marie, Lupberger, Joachim, Hildt, Eberhard, Luo, Guangxiang, Mclauchlan, John, Baumert, Thomas, Schuster, Catherine   +10 more
openaire   +4 more sources

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
core   +1 more source

Understanding the Interaction Determinants of CAPN1 Inhibition by CAST4 from Bovines Using Molecular Modeling Techniques

Molecules, 2014
HCV-induced CAPN activation and its effects on virus-infected cells in a host-immune system have been studied recently. It has been shown that the HCV-nonstructural 5A protein acts as both an inducer and a substrate for host CAPN protease; it ...
Han-Ha Chai, Dajeong Lim, Eunkyoung Jung, Bong-Hwan Choi, Yong-Min Cho   +4 more
doaj   +1 more source

Robustness of high‐throughput prediction of leaf ecophysiological traits using near infrared spectroscopy and poro‐fluorometry

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Water scarcity is a major threat to crop production and quality. Improving drought tolerance through variety selection requires a deeper understanding of plant ecophysiological responses, but large‐scale phenotyping remains a bottleneck. This study assessed the potential of high‐throughput tools (spectroscopy and poro‐fluorometry) to predict ...
Eva Coindre, Romain Boulord, Laurine Chir, Virgilio Freitas, Maxime Ryckewaert, Thomas Laisné, Virginie Bouckenooghe, Maëlle Lis, Llorenç Cabrera‐Bosquet, Agnès Doligez, Thierry Simonneau, Benoît Pallas, Aude Coupel‐Ledru, Vincent Segura   +13 more
wiley   +1 more source

Conserved Determinants for Membrane Association of Nonstructural Protein 5A fromHepatitis C Virus and Related Viruses [PDF]

Journal of Virology, 2007
ABSTRACT Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ...
Brass, Volker, Pal, Zsuzsanna, Sapay, Nicolas, Deléage, Gilbert, Blum, Hubert Erich Christoph, Penin, François, Moradpour, Darius   +6 more
openaire   +5 more sources

An integrated analysis of elbasvir/grazoprevir in Korean patients with hepatitis C virus genotype 1b infection [PDF]

Clinical and Molecular Hepatology, 2019
Background/Aims In the Republic of Korea, an estimated 231,000 individuals have chronic hepatitis C virus (HCV) infection. The aim of the present analysis was to evaluate the safety and efficacy of elbasvir/grazoprevir (EBR/GZR) administered for 12 weeks
Youn Jae Lee, Jeong Heo, Do Young Kim, Woo Jin Chung, Won Young Tak, Yoon Jun Kim, Seung Woon Paik, Eungeol Sim, Susila Kulasingam, Rohit Talwani, Barbara Haber, Peggy Hwang   +11 more
doaj   +1 more source

Impact of Crude Oil Contamination on Green Leafy Vegetables: Nutritional and Health Risk Assessments

Remediation Journal, Volume 36, Issue 2, Spring 2026.
ABSTRACT For decades, crude oil spills have been a serious environmental challenge which have led to the establishment of crude oil remediation intervention values (CRIV) by different national agencies to regulate the release of toxic petroleum hydrocarbons via these spills.
Johnson Oluwaseun Odukoya, Ronnie Lambert, Ruben Sakrabani   +2 more
wiley   +1 more source

GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication.

PLoS ONE, 2013
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a component of the replication complex associated with various cellular proteins. It has been reported that G protein pathway suppressor 2 (GPS2) is a potential NS5A-binding factor, as identified
Guodong Xu, Xiu Xin, Congyi Zheng
doaj   +1 more source