Results 81 to 90 of about 18,126 (202)

Impact of Crude Oil Contamination on Green Leafy Vegetables: Nutritional and Health Risk Assessments

Remediation Journal, Volume 36, Issue 2, Spring 2026.
ABSTRACT For decades, crude oil spills have been a serious environmental challenge which have led to the establishment of crude oil remediation intervention values (CRIV) by different national agencies to regulate the release of toxic petroleum hydrocarbons via these spills.
Johnson Oluwaseun Odukoya, Ronnie Lambert, Ruben Sakrabani   +2 more
wiley   +1 more source

Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver.

PLoS ONE, 2017
The hepatitis C virus nonstructural protein NS5A is involved in resistance to the host immune response, as well as the viral lifecycle such as replication and maturation.
Takeya Tsutsumi, Kazuya Okushin, Kenichiro Enooku, Hidetaka Fujinaga, Kyoji Moriya, Hiroshi Yotsuyanagi, Hideki Aizaki, Tetsuro Suzuki, Yoshiharu Matsuura, Kazuhiko Koike   +9 more
doaj   +1 more source

The Real-World Safety and Efficacy of Daclatasvir and Asunaprevir for Elderly Patients

Gut and Liver, 2018
Background/AimsAlthough daclatasvir with asunaprevir was approved in Japan for interferon ineligible or intolerant patients, patients aged ≥75 years were excluded in the phase III trial. The present study aimed to evaluate the safety and efficacy of this
Shinya Taki, Hideyuki Tamai, Yoshiyuki Ida, Naoki Shingaki, Akira Kawashima, Ryo Shimizu, Kosaku Moribata, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65. [PDF]

, 2016
Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide.
A Christensen, A Zhou, AY Chen, B Huang, ET Martin, F Mercurio, H Lukkarinen, HL Luo, J Hiscott, J Napetschnig, J Shen, KA Park, L Unterholzner, L Verstrepen, LF Chen, M Coiras, M Meriluoto, M Severa, MG Santoro, MS Hayden, N Edner, ND Perkins, Q Huang, R Dijkman, RE Randall, RN Silk, RW Korner, S Ghosh, SF Cotmore, T Allander, T Allander, T Lu, T Ursic, TD Gilmore, TE Morrison, W Shen, X Li, XF Deng, Y Hirose, Z Zheng, ZF Zhang   +40 more
core   +1 more source

Apolipoprotein E Interacts With Hepatitis C Virus Nonstructural Protein 5A and Determines Assembly of Infectious Particles [PDF]

Hepatology, 2010
Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. Restriction of HCV infection to human hepatocytes suggests that liver-specific host factors play a role in the viral life cycle.
Benga, Wagane, Krieger, Sophie, Dimitrova, Maria, Zeisel, Mirjam, Parnot, Marie, Lupberger, Joachim, Hildt, Eberhard, Luo, Guangxiang, Mclauchlan, John, Baumert, Thomas, Schuster, Catherine   +10 more
openaire   +4 more sources

Fungal Pathogen Activity and Stress‐Dependent Responses of Grapevine Wood to Esca and Drought

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Biotic and abiotic stresses alter the physiology of perennial plants, with consequences for fungal endophytes and disease expression. In grapevine, drought inhibits esca disease expression, but the underlying molecular interactions between the plant and fungi are unknown. We combined wood metatranscriptomics, metabolomics, and metabarcoding to
Marie Chambard, Dario Cantù, Giovanni Bortolami, Ninon Dell'Acqua, Nathalie Ferrer, Gregory A. Gambetta, Jadran F. Garcia, Pierre Gastou, Mélanie Massonnet, Samuele Moretti, Adam Rochepeau, Pierre Pétriacq, Marie Foulongne‐Oriol, Chloé E. L. Delmas   +13 more
wiley   +1 more source

Combination of Sofosbuvir-Ledipasvir and Sofosbuvir- Daclatasvir for Treatment HCV Patients in Indonesia

Jurnal Penyakit Dalam Indonesia, 2023
Introduction. Direct-acting antivirals (DAAs) has been developed for treatment hepatitis C virus (HCV). Therapy of HCV using DAA has shown high sustained virologic response (SVR) and shortening duration of therapy.
Andri Sanityoso Sulaiman, Irsan Hasan, Cosmas Rinaldi Adithya Lesmana, Juferdy Kurniawan, Gita Aprilicia, Yayah Nugroho, Nunuk Tri Wahyuni, Budiman Sujatmika Sulaiman   +7 more
doaj   +1 more source

Conserved Determinants for Membrane Association of Nonstructural Protein 5A fromHepatitis C Virus and Related Viruses [PDF]

Journal of Virology, 2007
ABSTRACT Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ...
Brass, Volker, Pal, Zsuzsanna, Sapay, Nicolas, Deléage, Gilbert, Blum, Hubert Erich Christoph, Penin, François, Moradpour, Darius   +6 more
openaire   +4 more sources

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, Volume 13, Issue 22, 17 April 2026.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses [PDF]

, 2017
SFTS phlebovirus (severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009. Here we report the generation of a recombinant SFTSV (rHB29NSsKO) that cannot express the viral non-
Brennan, Benjamin, Elliott, Richard M., Rezelj, Veronica V.   +2 more
core   +1 more source