Results 81 to 90 of about 3,421,850 (195)

The Real-World Safety and Efficacy of Daclatasvir and Asunaprevir for Elderly Patients

Gut and Liver, 2018
Background/AimsAlthough daclatasvir with asunaprevir was approved in Japan for interferon ineligible or intolerant patients, patients aged ≥75 years were excluded in the phase III trial. The present study aimed to evaluate the safety and efficacy of this
Shinya Taki, Hideyuki Tamai, Yoshiyuki Ida, Naoki Shingaki, Akira Kawashima, Ryo Shimizu, Kosaku Moribata, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

Magnetic Bead‐Based Ligand Fishing Identifies SARS‐CoV‐2 Main Protease Inhibitors From Reynoutria japonica

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A magnetic bead‐based ligand fishing workflow using immobilized SARS‐CoV‐2 Mpro was coupled with UPLC‐Q‐Exactive‐Orbitrap‐MS/MS to screen potential Mpro‐binding constituents directly from a crude Reynoutria japonica extract. Eight compounds were captured and annotated, of which six showed concentration‐dependent Mpro inhibition, with resveratrol ...
Yujing Huang, Chenjing Tian, Zhipeng Gu, Jinlian Liang, Duntao Zu, Jianni Yang, Wanrong Zhang, Nina Ren, Junxia Zheng   +8 more
wiley   +1 more source

Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles [PDF]

Journal of Virology, 2008
ABSTRACTNonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) possesses multiple and diverse functions in RNA replication, interferon resistance, and viral pathogenesis. Recent studies suggest that NS5A is involved in the assembly and maturation of infectious viral particles; however, precisely how NS5A participates in virus production has not
Takahiro, Masaki, Ryosuke, Suzuki, Kyoko, Murakami, Hideki, Aizaki, Koji, Ishii, Asako, Murayama, Tomoko, Date, Yoshiharu, Matsuura, Tatsuo, Miyamura, Takaji, Wakita, Tetsuro, Suzuki   +10 more
openaire   +2 more sources

Combination of Sofosbuvir-Ledipasvir and Sofosbuvir- Daclatasvir for Treatment HCV Patients in Indonesia

Jurnal Penyakit Dalam Indonesia, 2023
Introduction. Direct-acting antivirals (DAAs) has been developed for treatment hepatitis C virus (HCV). Therapy of HCV using DAA has shown high sustained virologic response (SVR) and shortening duration of therapy.
Andri Sanityoso Sulaiman, Irsan Hasan, Cosmas Rinaldi Adithya Lesmana, Juferdy Kurniawan, Gita Aprilicia, Yayah Nugroho, Nunuk Tri Wahyuni, Budiman Sujatmika Sulaiman   +7 more
doaj   +1 more source

Molecularly imprinted polymers based electrochemical sensors for biomarker detection in biofluids

InfoScience, Volume 3, Issue 3, September 2026.
This review systematically summarizes the evolution of molecularly imprinted polymer electrochemical sensors from bulk structures to advanced nano‐imprinted architectures. It decouples the complex matrix effects of clinical biofluids and evaluates interfacial engineering strategies for anti‐biofouling.
Tianrui Zhu, Guobao Yao, Haoming Jiang, Yuan Gao, Yinchao Zhao, Hao Shen, Dequn Wu, Qifeng Lu   +7 more
wiley   +1 more source

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation [PDF]

Molecular and Cellular Biology, 1998
The PKR protein kinase is a critical component of the cellular antiviral and antiproliferative responses induced by interferons. Recent evidence indicates that the nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) can repress PKR function in vivo, possibly allowing HCV to escape the antiviral effects of interferon.
M, Gale, C M, Blakely, B, Kwieciszewski, S L, Tan, M, Dossett, N M, Tang, M J, Korth, S J, Polyak, D R, Gretch, M G, Katze   +9 more
openaire   +2 more sources

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Real-life prevalence of resistance-associated variants against non-structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C

Virology Journal, 2017
Background Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the efficacy of DAAs. The aim of this
Jung Hwan Yu, Jung Il Lee, Kwan Sik Lee, Ja Kyung Kim   +3 more
doaj   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]

, 2012
BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly, Boyce, Mark, Roy, Polly, Celma, Cristina CP, Cristina C P Celma, Boyce Mark, Mark Boyce, Polly Roy, Celma Cristina C P   +8 more
core   +1 more source