Results 101 to 110 of about 13,111 (197)

Hepatitis C Virus Nonstructural Protein 5A Interacts with Immunomodulatory Kinase IKKε to Negatively Regulate Innate Antiviral Immunity. [PDF]

Mol Cells, 2022
Kang SM, Park JY, Han HJ, Song BM, Tark D, Choi BS, Hwang SB.   +6 more
europepmc   +1 more source

Interaction of Nonstructural Protein 5A of the Hepatitis C Virus with Src Homology 3 Domains Using Noncanonical Binding Sites

, 2013
Src homology 3 (SH3) domains are widely known for their ability to interact with other proteins using the canonical PxxP binding motif. Besides those well-characterized interaction modes, there is an increasing number of SH3 domain-containing complexes ...
Solyom, Z., Aladag, Amine, Hoffmann, Silke, Brutscher, B., Willbold, Dieter, Sophie Feuerstein, Melanie Schwarten, Zsófia Sólyom, Amine Aladağ, Feuerstein, S., Schwarten, Melanie, Bernhard Brutscher, Silke Hoffmann, Dieter Willbold   +13 more
core   +1 more source

Interferon signaling in chronic hepatitis C : mechanisms and implications for therapy [PDF]

, 2008
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide and can lead to liver cirrhosis and hepatocellular carcinoma.
Sarasin-Filipowicz, Magdalena
core   +1 more source

A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus

BMC Gastroenterology, 2012
Background The aims of this study were to assess the prevalence of hepatitis C virus (HCV) infection in Japanese patients with oral lichen planus and identify the impact of amino acid (aa) substitutions in the HCV core region and IFN-sensitivity ...
Nagao Yumiko, Sata Michio
doaj   +1 more source

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

, 1997
Hepatitis C virus (HCV) is the major cause of non-A non-B hepatitis and a leading cause of liver dysfunction worldwide. While the current therapy for chronic HCV infection is parenteral administration of type 1 interferon (IFN), only a fraction of HCV ...
Gale, Michael J., Hopkins, Deborah A., Korth, Marcus J., Tang, Norina M., Tan, Seng-Lai, Gretch, David R., Dever, Thomas E., Polyak, Stephen J., Katze, Michael G.   +8 more
core   +1 more source

Concomitant proton pump inhibitor use does not reduce the efficacy of elbasvir/grazoprevir: A pooled analysis of 1,322 patients with hepatitis C infection

Hepatology Communications, 2017
Concomitant proton pump inhibitor (PPI) use reduces plasma concentrations of certain nonstructural protein 5A inhibitors, which are key components of modern hepatitis C infection (HCV) treatments.
Nancy Reau, Michael N. Robertson, Hwa‐Ping Feng, Luzelena Caro, Wendy W. Yeh, Bach‐Yen T. Nguyen, Janice Wahl, Eliav Barr, Peggy Hwang, Stephanie O. Klopfer   +9 more
doaj   +1 more source

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A

, 2015
Background & AimsHepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a multifunctional protein playing a crucial role in diverse steps of the viral replication cycle and perturbing multiple host cell pathways.
Roth, Hanna, Lohmann, Volker, Zayas, Margarita, Hiet, Marie-Sophie, Willemsen, Joschka, Grünvogel, Oliver, Bartenschlager, Ralf, Ruggieri, Alessia, Tanaka, Yasuhito, Binder, Marco, Bauhofer, Oliver, Schirmacher, Peter, Bender, Silke, Lotteau, Vincent   +13 more
core   +1 more source

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

PLoS Pathogens, 2013
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an essential host factor of hepatitis C virus (HCV) replication. PI4KIIIα catalyzes the synthesis of phosphatidylinositol 4-phosphate (PI4P) accumulating in HCV replicating cells due ...
Simon Reiss, Christian Harak, Inés Romero-Brey, Danijela Radujkovic, Rahel Klein, Alessia Ruggieri, Ilka Rebhan, Ralf Bartenschlager, Volker Lohmann   +8 more
doaj   +1 more source

The Nucleocapsid Protein and Nonstructural Protein 10 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Enhance CD83 Production via NF-κB and Sp1 Signaling Pathways

, 2017
Porcine reproductive and respiratory syndrome, caused by porcine reproductive and respiratory syndrome virus (PRRSV), is a panzootic disease that is one of the most economically costly diseases to the swine industry.
Yongxiang Zhao, Juan Bai, Xianwei Wang, Qiaoya Zhang, Xi Chen, Ping Jiang, Haiyan Wang   +6 more
core   +1 more source

Daclatasvir: potential role in hepatitis C

Drug Design, Development and Therapy, 2013
Choongho Lee College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea  Abstract: Chronic hepatitis C virus (HCV) infection is responsible for the development of liver cirrhosis and hepatocellular carcinoma.
Lee C
doaj