Results 101 to 110 of about 3,421,850 (195)

HCV core residues critical for infectivity are also involved in core-NS5A complex formation.

PLoS ONE, 2014
Hepatitis C virus (HCV) infection is a major cause of liver disease. The molecular machinery of HCV assembly and particle release remains obscure. A better understanding of the assembly events might reveal new potential antiviral strategies.
Katarzyna Gawlik, James Baugh, Udayan Chatterji, Precious J Lim, Michael D Bobardt, Philippe A Gallay   +5 more
doaj   +1 more source

Outcomes for Cirrhotic Patients with Hepatitis C Virus 1b Treated with Asunaprevir and Daclatasvir Combination

Annals of Hepatology, 2017
Background: The efficacy and safety of asunaprevir + daclatasvir combination therapy for treatment of hepatitis C virus (HCV) in compensated cirrhotic patients was not fully evaluated in real-world.
Akihiro Tamori, Hoang Hai, Sawako Uchida-Kobayashi, Masaru Enomoto, Ritsuzo Kozuka, Hiroyuki Motoyama, Etsushi Kawamura, Atsushi Hagihara, Yuga Teranishi, Kanako Yoshida, Hiroyasu Morikawa, Yoshiki Murakami, Norifumi Kawada   +12 more
doaj   +1 more source

SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

mLife, Volume 5, Issue 3, Page 339-354, June 2026.
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang   +7 more
wiley   +1 more source

Small Signaling Peptides in Sorghum bicolor: Integrating Phylogeny and Gene Expression to Characterize Roles in Stem Development

Plant Direct, Volume 10, Issue 6, June 2026.
ABSTRACT Small signaling peptides (SSPs) are important regulators of plant growth, development, and responses to biotic and abiotic stress, yet their role in the C4 grass Sorghum bicolor is largely uncharacterized. To help fill this knowledge gap, 219 sorghum genes that encode SSPs were identified based on SSP sequences previously identified in ...
Evan Kurtz, Brian McKinley, John Mullet
wiley   +1 more source

Hepatitis C Virus Nonstructural Protein 5A Interacts with Immunomodulatory Kinase IKKε to Negatively Regulate Innate Antiviral Immunity. [PDF]

Mol Cells, 2022
Kang SM, Park JY, Han HJ, Song BM, Tark D, Choi BS, Hwang SB.   +6 more
europepmc   +1 more source

HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells.

PLoS ONE, 2012
Hepatitis C virus (HCV) infects B lymphocytes and induces mixed cryoglobulinemia and B cell non-Hodgkin's lymphoma. The molecular mechanism for the pathogenesis of HCV infection-mediated B cell disorders remains obscure. To identify the possible role for
Kenji Nakashima, Kenji Takeuchi, Kazuyasu Chihara, Tomoko Horiguchi, Xuedong Sun, Lin Deng, Ikuo Shoji, Hak Hotta, Kiyonao Sada   +8 more
doaj   +1 more source

Subcellular location and protein interactions of the infectious bronchitis virus gene 3 and 5 accessory proteins [PDF]

The avian coronavirus infectious bronchitis virus (IBV) expresses four nonstructural, non-gene 1 proteins (3a, 3b, 5a and 5b) which have been shown to be dispensable for virus replication in cell culture.
Davies, Marc Tudor
core  

Nonstructural protein 5A does not contribute to the resistance of hepatitis C virus replication to interferon alpha in cell culture [PDF]

, 2005
The hepatitis C virus (HCV) subgenomic replicon system was used to study a possible involvement of nonstructural protein 5A (NS5A) in the mechanisms of HCV resistance to interferon alpha (IFN-α). A series of chimeric HCV replicons was constructed.
Viazov, Sergei, Lohmann, Volker, Sergei Viazov, aus dem Siepen, Marc, Wiese, Manfred, Marc aus dem Siepen, Ross, Stefan, Volker Lohmann, Manfred Wiese, Roggendorf, Michael, Stefan Ross, Michael Roggendorf   +11 more
core   +1 more source

Functional analysis of the orthobunyavirus nucleocapsid (N) protein [PDF]

, 2008
Bunyamwera virus (BUNV) is the prototype of the family Bunyaviridae. It has a tripartite genome consisting of negative sense RNA segments called large (L), medium (M) and small (S). The S segment encodes the nucleocapsid protein (N) of 233 amino acids.
Eifan, Saleh A.
core   +2 more sources

A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus

BMC Gastroenterology, 2012
Background The aims of this study were to assess the prevalence of hepatitis C virus (HCV) infection in Japanese patients with oral lichen planus and identify the impact of amino acid (aa) substitutions in the HCV core region and IFN-sensitivity ...
Nagao Yumiko, Sata Michio
doaj   +1 more source