Results 101 to 110 of about 18,126 (202)
New Zealand Journal of Agricultural Research, Volume 69, Issue 2, April 2026.This study evaluated the influence of three pasture‐management systems on milk fatty acid (FA) profiles in New Zealand dairy cows: standard–contemporary (STD–CON), diverse–contemporary (DIV–CON), and diverse–regenerative (DIV–REG). The STD–CON pastures consisted of ryegrass–clover, whereas diverse pastures included up to 16 species of grasses, legumes,
Yaliska Moreno‐González +8 more
wiley +1 more source
MedComm, Volume 7, Issue 4, April 2026.The present study evaluated the antiviral potential of various lycorine derivatives and identified compound 7 as a promising candidate. Compound 7 demonstrated strong antiviral efficacy against both the original SARS‐CoV‐2 and its variants in vitro and in vivo.
Tingfu Du +11 more
wiley +1 more source
Zika virus infection reprograms global transcription of host cells to allow sustained infection. [PDF]
, 2017 Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection.
Bansal, Vikas +5 more
core +2 more sources
Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Functional plasticity of antibacterial EndoU toxins. [PDF]
, 2018 Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein.
Eschenfeldt, William H +11 more
core +1 more source
HCV core residues critical for infectivity are also involved in core-NS5A complex formation.
PLoS ONE, 2014 Hepatitis C virus (HCV) infection is a major cause of liver disease. The molecular machinery of HCV assembly and particle release remains obscure. A better understanding of the assembly events might reveal new potential antiviral strategies.
Katarzyna Gawlik +5 more
doaj +1 more source
Annals of Hepatology, 2017 Background: The efficacy and safety of asunaprevir + daclatasvir combination therapy for treatment of hepatitis C virus (HCV) in compensated cirrhotic patients was not fully evaluated in real-world.
Akihiro Tamori +12 more
doaj +1 more source
Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection [PDF]
, 2012 Dynamic, mRNA-containing stress granules (SGs) form in the cytoplasm of cells under environmental stresses, including viral infection. Many viruses appear to employ mechanisms to disrupt the formation of SGs on their mRNAs, suggesting that they represent
Eng, Kai Er +6 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement +12 more
wiley +1 more source
Identification of cellular targets of Hepatitis C Virus Nonstructural Protein 5A.
, 2005 Hepatitis C virus (HCV) is a small RNA virus that causes severe liver pathogenesis in humans. It encodes for 3 structural and at least 7 non- structural proteins. The non-structural protein 5A (NS5A) has been implicated in the deregulation of host cell signal transduction, interfering with signaling pathways that regulate cell growth, cell ...
openaire +2 more sources