Results 21 to 30 of about 18,126 (202)

Correction: Hepatitis C Virus Nonstructural Protein 5A Inhibits MG132-Induced Apoptosis of Hepatocytes in Line with NF-κB-Nuclear Translocation. [PDF]

PLoS ONE, 2015
PLOS ONE Staff
doaj   +2 more sources

Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host [PDF]

, 2013
Schmallenberg virus (SBV) is an emerging orthobunyavirus of ruminants associated with outbreaks of congenital malformations in aborted and stillborn animals.
A Bridgen, A Bridgen, A Kohl, AC Lowen, AJ Della-Porta, Alain Kohl, Andrew Shaw, Anna Janowicz, AR Elbers, B Hoffmann, B Xu, CA Evans, Catherine Lamm, Claudio Murgia, CM Southam, CT Walter, D Thomas, DH Cybinski, Esther Schnettler, Eva McGregor, F Arnaud, Friedemann Weber, G Barry, G Blakqori, G Blakqori, G Neumann, Gerald Barry, Ilaria M. Piras, JI Gillespie, JL Farmer, K Kupferschmidt, K Peperkamp, K Terasaki, K Wernike, KE Jones, Kerstin Hahn, KV Goller, LD Rasmussen, M Beer, M Bouloy, M Caporale, M Dominguez, M Palmarini, M Ratinier, M Spiegel, M Varela, Mandy Glass, Marco Caporale, Mariana Varela, Martin Beer, Massimo Palmarini, Melanie McFarlane, MJ Killip, MM Garigliany, MM Garigliany, NR Saunders, OR Causey, P Vialat, PJ Hotez, PT Leisnham, R Muller, RS Azevedo, S Shimshony, SE Randolph, T Ikegami, T Yanase, UJ Buchholz, V Herder, Vanessa Herder, VH Leonard, Wolfgang Baumgärtner, X Shi, Y Ogawa, YK Liao   +73 more
core   +16 more sources

Hepatitis C Virus Nonstructural Protein 5A (NS5A) Is an RNA-binding Protein [PDF]

Journal of Biological Chemistry, 2005
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to antagonize numerous cellular pathways, including the antiviral interferon-alpha response. However, the capacity of this protein to interact with the viral polymerase suggests a more direct role for NS5A in genome replication.
Luyun, Huang, Jungwook, Hwang, Suresh D, Sharma, Michele R S, Hargittai, Yingfeng, Chen, Jamie J, Arnold, Kevin D, Raney, Craig E, Cameron   +7 more
openaire   +3 more sources

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Mitophagy induced by classical swine fever virus nonstructural protein 5A promotes viral replication

Virus Research, 2022
The classical swine fever virus (CSFV) is one of the most harmful pathogens of swine and causes considerable economic loss. Mitophagy is a selective form of autophagy that degrades damaged mitochondria by combining with lysosomes. Previous studies have been reported that CSFV infection can induce mitophagy, but which effector protein is responsible for
Zhang, Chengcheng, Wang, Xiuling, Sun, Jiahao, Guo, Mengjiao, Zhang, Xiaorong, Wu, Yantao   +5 more
openaire   +2 more sources

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. [PDF]

PLoS Pathogens, 2009
Viruses are obligate intracellular parasites and therefore their replication completely depends on host cell factors. In case of the hepatitis C virus (HCV), a positive-strand RNA virus that in the majority of infections establishes persistence ...
Artur Kaul, Sarah Stauffer, Carola Berger, Thomas Pertel, Jennifer Schmitt, Stephanie Kallis, Margarita Zayas, Volker Lohmann, Jeremy Luban, Ralf Bartenschlager   +9 more
doaj   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E., Estes, M. K., Guix Arnau, Susana, Katayama, K., Sharp, T. M.   +4 more
core   +2 more sources

Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry [PDF]

Journal of Virology, 2015
ABSTRACT The life cycle of hepatitis C virus (HCV) is highly dependent on host cellular proteins for virus propagation. In order to identify the cellular factors involved in HCV propagation, we performed protein microarray assay using the HCV nonstructural 5A (NS5A) protein as a probe.
Chorong, Park, Saehong, Min, Eun-Mee, Park, Yun-Sook, Lim, Sangmin, Kang, Tetsuro, Suzuki, Eui-Cheol, Shin, Soon B, Hwang   +7 more
openaire   +2 more sources

A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. [PDF]

, 2014
UnlabelledPairing high-throughput sequencing technologies with high-throughput mutagenesis enables genome-wide investigations of pathogenic organisms. Knowledge of the specific functions of protein domains encoded by the genome of the hepatitis C virus ...
Arumugaswami, Vaithilingaraja, Chen, Shu-Hwa, Chen, Zugen, Chu, Virginia, Lin, Chung-Yen, Lo, Hung-Hao, Olson, C Anders, Qi, Hangfei, Remenyi, Roland, Stokelman, Tamar, Su, Sheng-Yao, Sun, Ren, Truong, Shawna, Wu, Nicholas C, Wu, Ting-Ting   +14 more
core   +2 more sources

Nonstructural Protein 5A of Hepatitis C Virus Inhibits the Function of Karyopherin β3 [PDF]

Journal of Virology, 2000
ABSTRACTIt has been suggested that nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) plays a role in the incapacitation of interferon by inactivation of RNA-dependent protein kinase PKR. In order to further investigate the role of NS5A, we tried to identify cellular proteins interacting with NS5A by using the yeast two-hybrid system.
Chung, KM, Lee, J, Kim, JE, Song, OK, Cho, S, Lim, J, Seedorf, M, Hahm, B, Jang, SK   +8 more
openaire   +3 more sources