Results 21 to 30 of about 13,111 (197)

Variability of the nonstructural 5A protein of hepatitis C virus type 3a isolates and relation to interferon sensitivity. [PDF]

The Journal of Infectious Diseases, 2002
International audienceThe nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) genotype 1 is thought to interact with several cellular proteins, including the double-stranded RNA-dependent protein kinase (PKR) induced by interferon (IFN).
Capron, D., Castelain, Sandrine, François, Catherine, Roussel, J., Duverlie, G., Khorsi-Cauet, Hafida, Jaillon, O., Penin, F., Wychowski, C., Meurs, E.   +9 more
core   +3 more sources

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile—Part 2

ChemMedChem, 2014
In ongoing studies towards novel hepatitis C virus (HCV) therapeutics, inhibitors of nonstructural protein 5A (NS5A) were evaluated. Specifically, starting from previously reported lead compounds, peripheral substitution patterns of a series of biaryl ...
Dayal, Satish, Nichols, Carly, David C. Blakemore, Duncan Hay, Wakenhut, Florian, David C. Pryde, Chris Pickford, Fiona Adam, Pryde, David C., David Leese, Cheung, Kathy, Pike, Andrew, Caroline Smith‐Burchnell, Shaw, Stephen, Stephen Shaw, Felice Daverio, Andrew Pike, Statham, Keith, Lesa Watson, Jean‐Yves Chiva, Darren Stead, Roberts, Lee R., Rob Webster, Chiva, Jean-Yves, Lee R. Roberts, Satish Dayal, Carly Nichols, David Stonehouse, Webster, Rob, Watson, Lesa, Samuel Crook, Milbank, Jared, Florian Wakenhut, Michael Paradowski, Keith Statham, Jared Milbank, Smith-Burchnell, Caroline, Blakemore, David C., Wybrow, Robert, Adam, Fiona, Paradowski, Michael, Daverio, Felice, Tran, Thien Duc, Hay, Duncan, Gilles H. Goetz, Thien Duc Tran, Robert Wybrow, Kathy Cheung, Crook, Samuel, Stonehouse, David, Westby, Mike, Mike Westby, Gardner, Iain, Pickford, Chris, Ye Che, Stead, Darren, Goetz, Gilles H., Leese, David, Che, Ye, Iain Gardner   +59 more
core   +3 more sources

PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. [PDF]

J Virol, 2020
PACSIN2 is a lipid-binding protein that triggers the tubulation of the phosphatidic acid-containing membranes. The functional involvement of PACSIN2 in the virus life cycle has not yet been demonstrated. We showed that phosphorylation of PACSIN2 displayed a negative effect on NS5A and core interaction. The most significant finding is that NS5A prevents
Nguyen LP, Tran SC, Suetsugu S, Lim YS, Hwang SB.   +4 more
europepmc   +4 more sources

The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts. [PDF]

Nucleic Acids Res, 2020
AbstractNumerous mammalian proto-oncogene and other growth-regulatory transcripts are upregulated in malignancy due to abnormal mRNA stabilization. In hepatoma cells expressing a hepatitis C virus (HCV) subgenomic replicon, we found that the viral nonstructural protein 5A (NS5A), a protein known to bind to viral RNA, also bound specifically to human ...
Guo L, Sharma SD, Debes JD, Beisang D, Rattenbacher B, Louis IV, Wiesner DL, Cameron CE, Bohjanen PR.   +8 more
europepmc   +6 more sources

Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses. [PDF]

Journal of Virology, 2006
International audienceNonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex.
Moradpour, D., Z. Pal, F. Penin, Pal, Zsuzsanna, Deléage, Gilbert, D. Moradpour, Penin, F., Blum, Hubert Erich Christoph, N. Sapay, Sapay, Nicolas, Brass, V., Sapay, N., Deleage, G., Moradpour, Darius, H. E. Blum, Penin, François, Blum, He, Brass, Volker, Pal, Z., G. Deleage, V. Brass   +20 more
core   +6 more sources

Resistance analysis of genotype 3 hepatitis C virus indicates subtypes inherently resistant to nonstructural protein 5A inhibitors. [PDF]

Hepatology, 2019
Hepatitis C virus (HCV) genotype (gt) 3 is highly prevalent globally, with non-gt3a subtypes common in Southeast Asia. Resistance-associated substitutions (RASs) have been shown to play a role in treatment failure. However, the role of RASs in gt3 is not
Smith D, Magri A, Bonsall D, Ip CLC, Trebes A, Brown A, Piazza P, Bowden R, Nguyen D, Ansari MA, Simmonds P, Barnes E, STOP-HCV Consortium.   +12 more
europepmc   +2 more sources

Sequential S232/S235/S238 Phosphorylation of the Hepatitis C Virus Nonstructural Protein 5A. [PDF]

J Virol, 2018
The nonstructural protein 5A (NS5A) of the hepatitis C virus was thought to undergo sequential intramolecular phosphorylation on a series of serine residues; however, direct evidence was missing. We offer the first direct evidence of a CKIα-mediated intramolecular sequential NS5A phosphorylation cascade from serine 232 through 235 to 238.
Hsu SC, Tsai CN, Lee KY, Pan TC, Lo CW, Yu MJ.   +5 more
europepmc   +4 more sources

Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A. [PDF]

J Neurosci, 2012
Apoptosis-enabling neuronal potassium efflux is mediated by an enhancement of K+ currents. In cortical neurons, increased currents are triggered by dual phosphorylation of Kv2.1 by Src and p38 at channel residues Y124 and S800. It was recently shown that a K+ current surge is also present in hepatocytes undergoing apoptosis, and that the hepatitis C ...
Norris CA, He K, Springer MG, Hartnett KA, Horn JP, Aizenman E.   +5 more
europepmc   +4 more sources

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. [PDF]

PLoS Pathogens, 2009
Viruses are obligate intracellular parasites and therefore their replication completely depends on host cell factors. In case of the hepatitis C virus (HCV), a positive-strand RNA virus that in the majority of infections establishes persistence ...
Artur Kaul, Sarah Stauffer, Carola Berger, Thomas Pertel, Jennifer Schmitt, Stephanie Kallis, Margarita Zayas, Volker Lohmann, Jeremy Luban, Ralf Bartenschlager   +9 more
doaj   +1 more source

Nonstructural Protein 5A Impairs DNA Damage Repair: Implications for Hepatitis C Virus-Mediated Hepatocarcinogenesis. [PDF]

J Virol, 2018
ABSTRACT RAD51-associated protein 1 (RAD51AP1) is a member of the multiprotein complexes postulated to carry out RAD51-mediated homologous recombination and DNA repair in mammalian cells. In the present study, we showed that hepatitis C virus (HCV) NS5A directly bound RAD51AP1 and increased the protein level of RAD51AP1 through modulation of ...
Nguyen TTT, Park EM, Lim YS, Hwang SB.
europepmc   +4 more sources