Hepatitis C virus nonstructural protein 5A inhibits thapsigargin-induced apoptosis. [PDF]
PLoS ONE, 2014 BackgroundWe previously reported that the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) down-regulates TLR4 signaling and lipopolysaccharide-induced apoptosis of hepatocytes. There have been several reports regarding the association between HCV
Xia Jiang +6 more
doaj +5 more sources
Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A. [PDF]
PLoS Pathogens, 2016 Hepatitis C virus (HCV) nonstructural protein (NS)5A is a RNA-binding protein composed of a N-terminal membrane anchor, a structured domain I (DI) and two intrinsically disordered domains (DII and DIII) interacting with viral and cellular proteins. While
Margarita Zayas +3 more
doaj +5 more sources
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling [PDF]
Lipids in Health and Disease, 2019 Background Steatosis is an important clinical manifestation associated with chronic hepatitis C virus (HCV) infection. AMP-activated protein kinase (AMPK), a major mediator of lipid metabolism, regulates HCV-associated hepatic steatosis, but the ...
Ziyu Meng +3 more
doaj +5 more sources
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. [PDF]
PLoS Pathogens, 2008 Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world population infected with this virus, the lack of a prophylactic ...
Nicole Appel +8 more
doaj +5 more sources
Autophagy Induced by the N-Terminus of the Classic Swine Fever Virus Nonstructural Protein 5A Protein Promotes Viral Replication [PDF]
Frontiers in Microbiology, 2021 Although classic swine fever virus (CSFV) infection has been reported to induce autophagy, the specific induced mechanism remains unrevealed. Nonstructural protein 5A (NS5A) of CSFV is a multiphosphorylated protein with multiple functions to regulate ...
Chengcheng Zhang +5 more
doaj +2 more sources
PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. [PDF]
J Virol, 2020 PACSIN2 is a lipid-binding protein that triggers the tubulation of the phosphatidic acid-containing membranes. The functional involvement of PACSIN2 in the virus life cycle has not yet been demonstrated. We showed that phosphorylation of PACSIN2 displayed a negative effect on NS5A and core interaction. The most significant finding is that NS5A prevents
Nguyen LP +4 more
europepmc +4 more sources
The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts. [PDF]
Nucleic Acids Res, 2020 AbstractNumerous mammalian proto-oncogene and other growth-regulatory transcripts are upregulated in malignancy due to abnormal mRNA stabilization. In hepatoma cells expressing a hepatitis C virus (HCV) subgenomic replicon, we found that the viral nonstructural protein 5A (NS5A), a protein known to bind to viral RNA, also bound specifically to human ...
Guo L +8 more
europepmc +6 more sources
Sequential S232/S235/S238 Phosphorylation of the Hepatitis C Virus Nonstructural Protein 5A. [PDF]
J Virol, 2018 The nonstructural protein 5A (NS5A) of the hepatitis C virus was thought to undergo sequential intramolecular phosphorylation on a series of serine residues; however, direct evidence was missing. We offer the first direct evidence of a CKIα-mediated intramolecular sequential NS5A phosphorylation cascade from serine 232 through 235 to 238.
Hsu SC +5 more
europepmc +4 more sources
Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A [PDF]
Nature Communications, 2016 Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for ...
Nari Kim +5 more
doaj +2 more sources
Real-world effectiveness and safety of sofosbuvir and nonstructural protein 5A inhibitors for chronic hepatitis C genotype 1, 2, 3, 4, or 6: a multicentre cohort study [PDF]
BMC Gastroenterology, 2020 Background We investigated real-world effectiveness and safety of sofosbuvir and the nonstructural protein 5A inhibitors in the treatment of patients infected with hepatitis C virus (HCV) genotypes 1, 2, 3, 4, or 6.
Phunchai Charatcharoenwitthaya +14 more
doaj +2 more sources