Results 31 to 40 of about 996 (173)

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado   +9 more
wiley   +1 more source

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

open access: yesAddiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson   +13 more
wiley   +1 more source

The Effects of Anti-Dementia and Nootropic Treatments on the Mortality of Patients with Dementia: A Population-Based Cohort Study in Taiwan.

open access: yesPLoS ONE, 2015
BackgroundFew studies have examined the contribution of treatment on the mortality of dementia based on a population-based study.ObjectiveTo investigate the effects of anti-dementia and nootropic treatments on the mortality of dementia using a population-
Chen-Yi Wu   +6 more
doaj   +1 more source

Dreaming conundrum

open access: yesJournal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Dreaming, a common yet mysterious cognitive phenomenon, is an involuntary process experienced by individuals during sleep. Although the fascination with dreams dates back to ancient times and gained therapeutic significance through psychoanalysis in the early twentieth century, its scientific investigation only gained momentum with the ...
Carlotta Mutti   +2 more
wiley   +1 more source

Measuring the Effects of Caffeine and L-Theanine on Cognitive Performance: A Protocol for Self-Directed, Mobile N-of-1 Studies

open access: yesFrontiers in Computer Science, 2020
Background: The growing consumer digital tools market has made using individual health data to inform lifestyle changes more accessible than ever.
Eddye Golden   +5 more
doaj   +1 more source

Medication Exposure Definitions in Perinatal Pharmacoepidemiology: Implications for Pregnancy Studies

open access: yesPaediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Exposure definitions in real‐world pregnancy studies vary across studies, data sources, treatments and outcomes, yet their impact on prevalence estimates remains unexamined. Objectives To identify the most used exposure definitions during the 1st trimester and evaluate their impact on prevalence estimates: Methods We reviewed 400 ...
Gabra Nohmie   +3 more
wiley   +1 more source

The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive‐Like Behavior in Mice

open access: yesBrain and Behavior, Volume 16, Issue 7, July 2026.
Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan   +8 more
wiley   +1 more source

Effectiveness of nootropic drugs with cholinergic activity in treatment of cognitive deficit: a review

open access: yesJournal of Experimental Pharmacology, 2012
Luisa Colucci,1,2 Massimiliano Bosco,2 Antonio Rosario Ziello,1,2 Raffaele Rea,1,2 Francesco Amenta,1 Angiola Maria Fasanaro21Centro di Ricerche Cliniche, Telemedicina e Telefarmacia, Università di Camerino, Camerino, 2Unit&agrave ...
Colucci L   +5 more
doaj  

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

open access: yesChirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz   +1 more
wiley   +1 more source

NOOTROPICS AND MELAXEN’ NEUROPROTECTIONAL ACTIVITY MORPHOPHARMACOLOGICAL ANALYSIS IN RATS’ ACUTE CEREBRAL ISCHEMIA

open access: yesМедицинский вестник Юга России, 2015
purpose: оn the base of complex morpho-pharmacological analysis to evaluate nootropics and its combinations with melaxen effects in rats experimental acute cerebral ischemia.materials and methods: morphological (light-, electron microscopic and ...
E. V. Gantsgorn   +2 more
doaj   +1 more source

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