Results 41 to 50 of about 624 (119)

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Dreaming conundrum

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Dreaming, a common yet mysterious cognitive phenomenon, is an involuntary process experienced by individuals during sleep. Although the fascination with dreams dates back to ancient times and gained therapeutic significance through psychoanalysis in the early twentieth century, its scientific investigation only gained momentum with the ...
Carlotta Mutti, Francesca Siclari, Ivana Rosenzweig   +2 more
wiley   +1 more source

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

Addiction, Volume 121, Issue 11, Page 2897-2958, November 2026.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson, Thomas Parkhouse, Chloe Burke, Monika Halicka, Jennifer C. Palmer, Hend Gabr, Rebecca Wilson, Katie E. Webster, Francesca Spiga, Sarah Dawson, Deborah M. Caldwell, Jennifer Scott, Julian P. T. Higgins, Jelena Savović   +13 more
wiley   +1 more source

Therapeutic Potential of Oxiracetam in Neurocognitive Disorders: A Narrative Review

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Purpose: Cognitive impairment is a growing global health concern associated with aging, neurodegenerative diseases, stroke, and traumatic brain injury. Existing pharmacological treatments, including cholinesterase inhibitors and memantine, provide limited and variable benefits.
Hafsa Ali, Syeda Maliha, Sundas Ishtiaq, Omer Al‐Karawi, Mohammed Hammad Jaber Amin   +4 more
wiley   +1 more source

Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Mild cognitive impairment (MCI) carries a risk of further cognitive decline; thus, early diagnosis and intervention are important. The ASCEND Expert Group presents novel algorithms for (1) cognitive assessment/clinical diagnosis and (2) MCI management, emphasizing a multimodal strategy encompassing metabolic/cerebrovascular risk reduction, sensory loss
Nagaendran Kandiah, Yee Fai Chan, Darwin Dasig, Jacqueline Dominguez, Kar Chai Koh, Si Ching Lim, Paulus Anam Ong, Encarnita Raya‐Ampil, Raymond Chee Seong Seet, Vorapun Senanarong, Kit Mun Tan, Maw Pin Tan, Trần Công Thắng, Tong Mai Trang, Yuda Turana, Cuibai Wei, Ralf Ihl   +16 more
wiley   +1 more source

Medication Exposure Definitions in Perinatal Pharmacoepidemiology: Implications for Pregnancy Studies

Paediatric and Perinatal Epidemiology, Volume 40, Issue 6, Page 681-690, August 2026.
ABSTRACT Background Exposure definitions in real‐world pregnancy studies vary across studies, data sources, treatments and outcomes, yet their impact on prevalence estimates remains unexamined. Objectives To identify the most used exposure definitions during the 1st trimester and evaluate their impact on prevalence estimates: Methods We reviewed 400 ...
Gabra Nohmie, Anick Bérard, Anton Pottegård, Mette Bliddal   +3 more
wiley   +1 more source

The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive‐Like Behavior in Mice

Brain and Behavior, Volume 16, Issue 7, July 2026.
Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan, Wang Zihao, Leng Yujia, Luan Rongrong, Zhao Xin, Yang Juanini, Liu Junchang, Feng Yuchao, Wang Peng   +8 more
wiley   +1 more source

Use of Nootropics in Patients with Mild Cognitive Impairment to Promote Neuroplasticity using Virtual Reality Neuro-Rehabilitation [PDF]

, 2022
Mild Cognitive Impairment increases an individual's susceptibility to negative health outcomes, such as increased risk of falling, other physical disabilities, increased frequency of hospitalizations, and death. The frequency of mild cognitive impairment
Vancea, Amalia Teodora, Spiru, Luiza
core  

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

In Search of Genetic Agency: On the Uses and Actionability of Direct‐to‐Consumer Genetic Test Results in Biohacking Practices

Sociology of Health &Illness, Volume 48, Issue 6, July 2026.
ABSTRACT The article examines why and with what consequences biohacking individuals use direct‐to‐consumer genetic tests (DTC GTs). Based on thematic coding of 15 semi‐structured interviews, it argues that these users generally see themselves as capable of generating actionable knowledge to optimise future health by manipulating their ‘milieu’. DTC GTs
Carsten Stage
wiley   +1 more source