Results 91 to 100 of about 147,087 (295)

Dual contributions of noradrenaline to behavioural flexibility and motivation [PDF]

, 2018
International audienceINTRODUCTION: While several theories have highlighted the importance of the noradrenergic system for behavioral flexibility, a number of recent studies have also shown a role for noradrenaline in motivation, particularly in effort ...
Walton, Mark, E, Walton, Mark, Walton, Mark,, Bouret, Sébastien,, Jahn, Caroline, I, Bouret, S, Jahn, C, Varazzani, C, Bouret, Sebastien, Jahn, Caroline I, Varazzani, Chiara, Bouret, Sébastien, G., Walton, Mark E, Blain, Bastien, Gilardeau, S, Sallet, Jerome, Blain, B, Jahn, Caroline,, Gilardeau, Sophie   +18 more
core   +2 more sources

Pupil dilation signals uncertainty and surprise in a learning gambling task

Frontiers in Behavioral Neuroscience, 2014
Pupil dilation under constant illumination is a physiological marker which modulation is related to several cognitive functions involved in daily decision making.
Claudio eLavin, Claudio eLavin, René eSan Martín, René eSan Martín, Eduardo eRosales Jubal, Eduardo eRosales Jubal, Eduardo eRosales Jubal   +6 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Serotonin and noradrenaline signalling in binge-like long-term alcohol intake and associated maladaptive effects in adult mice [PDF]

, 2017
Alcohol dependence is a debilitating disorder with current therapies displaying limited efficacy and/or compliance. This thesis investigated the contribution of two key neurotransmitters; noradrenaline and serotonin in alcohol dependence using a mouse ...
Patkar, Omkar Laxman
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Association Between Intraoperative Noradrenaline Infusion and Outcomes in Older Adult Patients Undergoing Major Non-Cardiac Surgeries: A Retrospective Propensity Score-Matched Cohort Study [PDF]

Ya-Jun Yang,1,* Yu-Mei Feng,1,* Tong-Xuan Wang,1 Jing-Yun Wang,2 Qian-Yun Pang,1 Hong-Liang Liu1 1Department of Anesthesiology, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China; 2School of Medicine, Chongqing University,
Wang TX, Liu HL, Feng YM, Pang QY, Wang JY, Yang YJ   +5 more
core  

Hormonal and Psychological Responses to a Single Cold-Water Immersion in Regularly Winter-Swimming Males

Applied Sciences
The psychological response to cold is complex. The present study aimed to determine if regular winter swimmers differed from those who did not practise winter swimming in terms of (1) daily perceived emotional states, (2) subjectively perceived ...
Aneta Teległów, Krzysztof Wrześniewski, Jan Blecharz   +2 more
doaj   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Monoaminergic System Modulation in Depression and Alzheimer’s Disease: A New Standpoint?

Frontiers in Pharmacology, 2019
The prevalence of depression has dramatically increased, and it has been estimated that over 300 million people suffer from depression all over the world. Depression is highly comorbid with many central and peripheral disorders.
Maria Grazia Morgese, Luigia Trabace
doaj   +1 more source

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source