Results 71 to 80 of about 147,087 (295)

The Noradrenergic System in Parkinson’s Disease

Frontiers in Pharmacology, 2020
Nowadays it is well accepted that in Parkinson’s disease (PD), the neurodegenerative process occurs in stages and that damage to other areas precedes the neuronal loss in the substantia nigra pars compacta, which is considered a pathophysiological ...
Elena Paredes-Rodriguez, Elena Paredes-Rodriguez, Sergio Vegas-Suarez, Sergio Vegas-Suarez, Teresa Morera-Herreras, Teresa Morera-Herreras, Philippe De Deurwaerdere, Cristina Miguelez, Cristina Miguelez   +8 more
doaj   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys

Frontiers in Neuroanatomy, 2017
Parkinson’s disease (PD) is a neurodegenerative disease with both motor and non-motor manifestations. Hyposmia is one of the early non-motor symptoms, which can precede motor symptoms by several years.
Christian Pifl, Harald Reither, Natalia Lopez-Gonzalez del Rey, Natalia Lopez-Gonzalez del Rey, Carmen Cavada, Jose A. Obeso, Jose A. Obeso, Javier Blesa, Javier Blesa   +8 more
doaj   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Bradykinin and noradrenaline preconditioning influences level of antioxidant enzymes SOD, CuZn-SOD, Mn-SOD and catalase in the white matter of spinal cord in rabbits after ischemia/reperfusion

European Journal of Histochemistry, 2019
The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn ...
Marianna Danková, Iveta Domoráková, Zuzana Fagová, Milan Stebnický, Alexandra Kunová, Eva Mechírová   +5 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Noradrenaline modulates mechanically evoked responses in the rat spinal dorsal horn: an in vivo patch-clamp study [PDF]

, 2019
Motoki Sonohata,1 Atsushi Doi,2 Toshiharu Yasaka,3 Daisuke Uta,4 Masaaki Mawatari,1 Megumu Yoshimura5,61Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga, Japan; 2Department of Physical Therapy, Kumamoto Health Science ...
Mawatari M, Yoshimura M, Sonohata M, Uta D, Yasaka T, Doi A   +5 more
core  

Contribution of liver nerves, glucagon, and adrenaline to the glycaemic response to exercise in rats [PDF]

, 1994
The contribution of hepatic sympathetic innervation, glucagon and adrenaline to the glycaemic response to exercise was investigated in rats. Hepatically denervated (LDX) or sham operated (SHAM) rats with permanent catheters were therefore submitted to ...
B. AHRÉN, Dijk, G. van,, Bouws, G., van Dijk, Gertjan; id_orcid, Ahrén, B., Lindfeldt, J., KUVAKİ BALKAN, BAHAR, Bouws, G.,, SCHEURINK, AJW, AHREN, B, Balkan, B.,, Balkan, B., A. J. W. SCHEURINK, VAN DIJK, G, BOUWS, G, LINDFELDT, J, Scheurink, A.J.W., BALKAN, B, STEFFENS, AB, G. BOUWS, Steffens, A.B.,, B. BALKAN, Ahrén, B.,, Scheurink, A.J.W.,, A. B. STEFFENS, Steffens, A.B., Lindfeldt, J.,, G. VAN DIJK, van Dijk, Gertjan, VANDIJK, G, J. LINDFELDT   +30 more
core   +1 more source

SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES

Frontiers in Cellular Neuroscience, 2015
Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago.
Marco eCosentino, Franca eMarino, Georges J.M. Maestroni   +2 more
doaj   +1 more source

Increased Noradrenaline as an Additional Cerebrospinal Fluid Biomarker in PSP-Like Parkinsonism

Frontiers in Aging Neuroscience, 2020
Academic centers utilize sequential clinical and neuroimaging assessments, including morphometric ratios, to obtain an unequivocal diagnosis of the non-synucleinopathic forms of Parkinsonism, such as progressive supranuclear palsy (PSP), however, a 1–2 ...
Rocco Cerroni, Claudio Liguori, Alessandro Stefani, Matteo Conti, Elena Garasto, Mariangela Pierantozzi, Nicola B. Mercuri, Sergio Bernardini, Giorgio Fucci, Renato Massoud   +9 more
doaj   +1 more source