Results 101 to 110 of about 191,218 (299)

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeum Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats

eLife
Extinction is a specific example of learning where a previously reinforced stimulus or response is no longer reinforced, and the previously learned behaviour is no longer necessary and must be modified.
Simon Lui, Ashleigh K Brink, Laura H Corbit   +2 more
doaj   +1 more source

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]

, 1993
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M., Horowski, R., Kalveram, K. T., Lange, Klaus W., Löschmann, P. A., Riederer, Peter, Sofic, E., Wachtel, H.   +7 more
core   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

COMPARISON OF EFFICACY ON NORADRENALINE AND TERLIPRESSIN IN HEPATORENAL SYNDROME IN THE PATIENTS OF DECOMPENSATED CIRRHOSIS – A RANDOMIZED CONTROLLED STUDY

Pakistan Armed Forces Medical Journal, 2019
Objective: To compare the efficacy of noradrenaline and terlipressin in hepatorenal syndrome. Study Design: Randomized controlled trial. Place and Duration of Study: Combined Military Hospital Lahore, from May 2018 to Jan 2019.
Muhammad Siddique, Mansoor Ud Din Sajid, Omar Ahsan   +2 more
doaj  

Source, triggers and clinical implications of hyperlactemia in patients undergoing mitral valve surgery using Custodiol cardioplegia [PDF]

, 2013
Postoperative blood hyperlactaemia is an indicator of organ anaerobic metabolism and is associated with morbidity after cardiac surgery. This prospective study aims to explore the source, triggers and clinical implications for hyperlactaemia in patients ...
Angelini, Gianni D, Ascione, Raimondo, Mangino, Domenico, Polesel, Elvio, Suleiman, M.Saadeh, Venturini, Andrea, Zanchettin, Chiara, Zoffoli, Giampaolo   +7 more
core   +2 more sources

O‐Terphenyl‐basierte Familie konjugierter Makrozyklen: Selektive Erkennung von Phenylalanin im Wasser und Interaktion mit Insulin

Angewandte Chemie, EarlyView.
Diese Studie beschreibt die Herstellung und Eigenschaften einer neuen Familie von o‐Terphenyl‐basierten Makrozyklen, TP[n] (n = 2‐8). Der Trimer bindet Phenylalanin in Wasser sehr effizient und ist dabei zehnmal selektiver als bei anderen Aminosäuren und aromatischen Neurotransmittern.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source

The role of the vesicular monoamine transporter 2 in the inhibitory effect of tetrabenazine and valbenazine compared to reserpine on the vesicular release of monoamine transmitters

Frontiers in Cellular Neuroscience
BackgroundVesicular monoamine transporter 2 (VMAT-2) plays a vital role in packaging cytosolic monoamine transmitters into axon terminal vesicles, which can be released in response to action potentials. Reserpine (RSP), a classical irreversible inhibitor
Fruzsina Maácz, Fruzsina Maácz, Erika Gyöngyi Bán, Attila Brassai, Beáta Sperlágh, E. Sylvester Vizi, E. Sylvester Vizi   +6 more
doaj   +1 more source

Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate [PDF]

, 1992
1. In bovine adrenal chromaffin cells made permeable either to molecules less than or equal to 3 kDa with alphatoxin or to proteins less than or equal to 150 kDa with streptolysin O, the GTP analogues guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG)
Ahnert-Hilger, G., Gratzl, Manfred, Rosenthal, W., Spicher, K., Stecher, B., Wegenhorst, U.   +5 more
core  

o‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin

Angewandte Chemie International Edition, EarlyView.
This study presents the synthesis and binding properties of a new family of o‐terphenyl‐based macrocycles, TP[n] (n = 2‐8). The trimer variant efficiently binds phenylalanine in water with a 10‐fold selectivity compared to other amino acids and aromatic neurotransmitters.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source