Results 111 to 120 of about 138,491 (253)

Activated charcoal filtration profoundly alters systemic noradrenaline concentrations during hepatic chemosaturation: A prospective cohort study. [PDF]

PLoS One
Turra J, Fischer D, Öcal O, Biecker O, Mayer P, Grieshaber P, Wenzel F, Karck M, Nikolic M, von der Forst M, Weigand M, Kauczor HU, Hassel JC, Lichtenstern C, Dietrich M, Rehn P.   +15 more
europepmc   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

The impact of blood pressure targets on haemodynamics in patients with cardiogenic shock caused by infarction-related out-of-hospital cardiac arrest: a substudy of the BOX-trial. [PDF]

Eur Heart J Acute Cardiovasc Care
Ten Berg S, Beske RP, Grand J, Schmidt H, Kjærgaard J, Møller JE, Jessen MMB, Henriques JPS, Hassager C.   +8 more
europepmc   +1 more source

Incidental Detection of Portal Venous Gas During POCUS in a Neonate With Necrotizing Enterocolitis and Intestinal Perforation: A Case Report

Journal of Clinical Ultrasound, EarlyView.
Point‐of‐care ultrasound performed at the bedside identified hepatic portal venous gas in a critically ill neonate, prompting urgent evaluation and revealing intestinal perforation due to necrotizing enterocolitis. This case highlights the potential of POCUS to accelerate diagnosis when clinical signs are subtle or nonspecific.
Tiago Henrique de Souza, Elisa Caixeta Fallieri Nascimento, Fernando de Lima Carioca, Nayara Hillebrand Franzon, Humberto Magalhães Silva   +4 more
wiley   +1 more source

6 weeks of fartlek-style endurance training does not alter physiological responses to mild cold exposure but attenuates the cold-induced plasma noradrenaline response: A randomized, matched control trial. [PDF]

J Clin Transl Endocrinol
Braunsperger A, Becker L, Camargo DP, Radsak S, Paintner M, Kossenakis D, Song X, Kraus A, Birnkammer A, Mesmer S, Stengel J, Frank L, Kuger S, Mather T, Peltola E, Könen M, Liebetanz K, Zorn J, De Angelis M, de Angelis MH, Tischer D, Soriano-Arroquia A, Georgiadi A, Schönfelder M, Wackerhage H.   +24 more
europepmc   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Phenylephrine Versus Noradrenaline for the Prevention and Treatment of Spinal-Induced Hypotension During Caesarean Section: A Literature Review. [PDF]

Cureus
Alrashid MA, Hamdan JH, Ansari Lari S.
europepmc   +1 more source

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang, Xin‐Yue Han, Li‐An Huang, Yu‐Sheng Zhang, Heng Meng, An‐Ding Xu   +5 more
wiley   +1 more source

The association between documented right ventricular dysfunction and in-hospital mortality in mechanically ventilated critically ill patients receiving a noradrenaline infusion: A retrospective observational cohort study. [PDF]

Crit Care Resusc
Tan LH, Paul E, Simpson A, Marasco S, Orde S, Hare J, Udy A.   +6 more
europepmc   +1 more source