Results 131 to 140 of about 41,607 (263)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang   +6 more
wiley   +1 more source

Effects of Dexmedetomidine on the Behavioral Outcomes in Streptozotocin‐Induced Alzheimer's Disease Rats

open access: yesBrain and Behavior, Volume 16, Issue 1, January 2026.
Dexmedetomidine at 25 µg/kg effectively reverses working and spatial memory deficits in a streptozotocin (STZ)‐induced rat model of Alzheimer's disease, restoring Y‐maze alternation and Morris Water Maze performance. Higher doses show no clear benefit, highlighting Dex‐25 as a promising neuroprotective candidate.
Mina Mohasel‐Roodi   +5 more
wiley   +1 more source

Acute Stress Attenuates Hepatic Ischemia–Reperfusion Injury via Hypothalamic CRH Neuron‐Induced HPA Axis Activation

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study demonstrates the protective effect of acute restraint stress (ARS) against hepatic ischemia–reperfusion injury (HIRI) in mice and investigates its specific neuroendocrine mechanisms. During ARS, excitability of PVNCRH neurons significantly increases, which drives HPA axis to release corticosterone, thereby reducing hepatic inflammation and ...
Xiaoqi Lin   +12 more
wiley   +1 more source

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Weidong Zhang   +5 more
wiley   +1 more source

Synergetic effect of a DSP4-induced locus coeruleus lesion and systemic LPS exacerbates substantia nigra dopaminergic neuron loss. [PDF]

open access: yesSci Rep
Şimşek F   +7 more
europepmc   +1 more source

Noradrenergic and dopaminergic involvement in novelty modulation of aversive memory generalization of adult rats

open access: green, 2019
Karine Ramires Lima   +7 more
openalex   +2 more sources

Noradrenergic transmission (reply) [PDF]

open access: yesNature, 1980
G. D. S. HIRST, T. O. NEILD
openaire   +1 more source

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