Results 131 to 140 of about 77,506 (299)

The role of CA1 α-adrenoceptor on scopolamine induced memory impairment in male rats [PDF]

open access: yes, 2010
Introduction: Similarities in the memory impairment between Alzheimer patients and scopolamine treated animals have been reported. In the present study, the possible role of α-adrenergic receptors of the dorsal hippocampus on scopolamine state-dependent ...
Azami, N.S.   +5 more
core  

Early life stress and hormonal status influence orexin‐1 receptor expression in structures regulating cardiorespiratory responses to CO2

open access: yesExperimental Physiology, EarlyView.
Abstract Excessive cardiorespiratory responses to CO2 are a hallmark of panic disorder (PD). Female sex and exposure to early life stress are risk factors for PD. Neonatal maternal separation (NMS; 3 h/day, postnatal days 3–12) augments the ventilatory response to CO2 by ∼35% relative to controls; this effect is most notable during pro‐oestrus but is ...
Stéphanie Fournier   +3 more
wiley   +1 more source

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source

5‐HT2 antagonism indirectly increases motor unit discharge rate and cervicomedullary motor evoked potential amplitude during submaximal elbow flexions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Motoneurone excitability of the elbow flexors was assessed in healthy human participants before and after the ingestion of the 5‐HT2 receptor antagonist cyproheptadine or a placebo. A, participants were seated upright, with their right arm attached to a custom torque transducer with bipolar EMG and a 64‐channel high‐density EMG ...
Tyler T. Henderson   +3 more
wiley   +1 more source

Urinary Metabolic Biomarkers of Attentional Control in Children With Attention‐Deficit/Hyperactivity Disorder: A Dimensional Approach Through 1H NMR‐Based Metabolomics

open access: yesNMR in Biomedicine, Volume 38, Issue 8, August 2025.
This study identified five attentional control subgroups in school‐aged children, with and without ADHD, using VR‐based behavioral tests. NMR metabolomics revealed subgroup‐specific urinary metabolic profiles linked to energy and amino acid metabolism.
Ana del Mar Salmerón   +6 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

open access: yesEuropean Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone   +28 more
wiley   +1 more source

Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders. [PDF]

open access: yes, 2014
Methylphenidate (MPH) reduces hyperactive-impulsive symptoms common in children with autism spectrum disorders (ASDs), however, response and tolerability varies widely.
Aman, MG   +13 more
core  

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

open access: yesFundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo   +9 more
wiley   +1 more source

Chemoanatomical organization of the noradrenergic input from locus coeruleus to the olfactory bulb of the adult rat [PDF]

open access: green, 1989
John H. McLean   +4 more
openalex   +1 more source

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