Results 61 to 70 of about 77,506 (299)

Volatilome and Antinociceptive Activity of the Traditional Preparation and Compounds from Ageratina grandifolia (Regel) R.M. King & H. Rob.

Chemistry &Biodiversity, EarlyView.
Abstract An infusion of Ageratina grandifolia, a traditional preparation, and major compounds [3,5‐diprenyl‐4‐hydroxyacetophenone (1), O‐methylencecalinol (2), encecalin (3), and encecalinol (4)], tested at 10, 31.6, and 100 mg/kg, intragastrically administered, showed a significant antinociceptive effect in both phases of the formalin test in mice ...
José Alberto Gutiérrez‐González, Isabel Rivero‐Cruz, José L. Villaseñor, Gabriela García‐Marín, Ana Laura Martínez, Rachel Mata   +5 more
wiley   +1 more source

Epistasis between 5-HTTLPR and ADRA2B polymorphisms influences attentional bias for emotional information in healthy volunteers [PDF]

, 2012
Individual differences in emotional processing are likely to contribute to vulnerability and resilience to emotional disorders such as depression and anxiety.
Anthony S. David, Ayana A. Gibbs, Bradley, Harmer, Kees van Heeringen, Kris H. Naudts, Kucera, Kwang, Moore, Nelson, Routledge, Ruben T. Azevedo, Serretti   +12 more
core   +2 more sources

Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA study flow diagram. ABSTRACT Background Elevated high blood pressure is controlled by complicated, little‐understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure‐related genomic loci have been identified through previous genome‐wide association
Lilik Sukesi, Yunia Sribudiani, Steven Yulius Usman, Eric Ricardo Yonatan, Ahmedz Widiasta, Noormarina Indraswari, Ria Bandiara, Nanny N. M. Soetedjo   +7 more
wiley   +1 more source

Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies

Frontiers in Aging Neuroscience, 2018
Noradrenergic dysfunction contributes to cognitive impairment in Alzheimer's Disease (AD) and Parkinson's Disease (PD). Conventional therapeutic strategies seek to enhance cholinergic and dopaminergic neurotransmission in AD and PD, respectively, and few
Andrew C. Peterson, Andrew C. Peterson, Chiang-shan R. Li, Chiang-shan R. Li, Chiang-shan R. Li   +4 more
doaj   +1 more source

Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. [PDF]

PLoS ONE, 2013
The occurrence of catechol-O-methyltransferase (COMT) in presynaptic neurons remains controversial. This study utilized dopaminergic and noradrenergic toxins to assess the presence of COMT in the presynaptic neurons originating from the substantia nigra,
Nadia Schendzielorz, Juha-Pekka Oinas, Timo T Myöhänen, Ilkka Reenilä, Atso Raasmaja, Pekka T Männistö   +5 more
doaj   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, EarlyView.
Adrenergic signaling through ADRB2 modulates phagocytosis in microglia. Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia. ADRB2 activation inhibits both P2Y6 function and gene expression. ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their environment ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling. [PDF]

, 2015
Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning.
Alessandra Ghigo, Angelo Maffei, Daniela Carnevale, Emilio Hirsch, Fabio Pallante, Franklin KBJ, Giuseppe Lembo, Ivana D'Andrea, Roberta Iacobucci, Stefania Fardella, Valentina Fardella   +10 more
core   +1 more source

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, EarlyView.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

Elevated Norepinephrine may be a Unifying Etiological Factor in the Abuse of a Broad Range of Substances: Alcohol, Nicotine, Marijuana, Heroin, Cocaine, and Caffeine

Substance Abuse: Research and Treatment, 2013
A wide range of commonly abused drugs have effects on the noradrenergic neurotransmitter system, including alterations during acute intoxication and chronic use of these drugs.
Paul J. Fitzgerald
doaj   +1 more source

Rest–Activity Disturbances Correlate with Core Features in Dementia with Lewy Bodies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Sleep–wake disturbances are a clinically important and poorly studied feature of dementia with Lewy bodies (DLB) due to the challenges of in‐laboratory polysomnography in this population. Objectives To compare rest–activity rhythms in DLB, Parkinson's disease (PD), and age‐matched controls using home‐based wrist actigraphy and ...
Jack Anderson, Nicholas K.H. Chiu, Jonathon E. Pye, Maria Comas‐Soberats, Aaron Lam, Ronald R. Grunstein, Simon J.G. Lewis, Elie Matar   +7 more
wiley   +1 more source