Results 31 to 40 of about 961 (135)

Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain [PDF]

Neuropsychopharmacology, 1993
Like fluoxetine, the N-demethylated metabolite norfluoxetine exists in R- and S-enantiomeric forms. S-Norfluoxetine inhibited serotonin (5-HT) uptake and [3H]paroxetine binding to 5-HT uptake sites with a pKi of 7.86 and 8.88 or 14 and 1.3 nM, respectively, whereas R-norfluoxetine was 22 and 20 times, respectively, less potent.
D T, Wong, F P, Bymaster, L R, Reid, D A, Mayle, J H, Krushinski, D W, Robertson   +5 more
openaire   +2 more sources

A novel chiral GC/MS method for the analysis of fluoxetine and norfluoxetine enantiomers in biological fluids

Journal of Pharmacy and Bioallied Sciences, 2012
Aims: A novel robust chiral gas chromatographic/mass spectrometric (GC/MS) method for the separation and measurement of fluoxetine and norfluoxetine enantiomers in urine and plasma was developed.
Janet Mifsud, Lino J Sghendo
doaj   +1 more source

Fluoxetine does not impair motor function in patients with Parkinson's disease: Correlation between mood and motor functions with plasma concentrations of fluoxetine/norfluoxetine [PDF]

Vojnosanitetski Pregled, 2012
Background/Aim. Selective serotonin reuptake inhibitors are the most commonly chosen antidepressants in patients with Parkinson's disease (PD). The aim of our study was to assess the influence of fluoxetine (Flu) on motor functions in patients with PD.
Kostić Vladimir, Džoljić Eleonora, Todorović Zoran, Mijajlović Milija, Svetel Marina, Stefanova Elka, Dragašević Nataša, Petrović Igor, Milošević Milenko, Kovačević Ivan, Miljković Branislava, Pokrajac Milena, Prostran Milica   +12 more
doaj   +1 more source

Disposition of Chiral and Racemic Fluoxetine and Norfluoxetine Across Childbearing [PDF]

Journal of Clinical Psychopharmacology, 2010
To add to the limited data on the clinical pharmacology of antidepressants during pregnancy, we examined the dose-corrected chiral and racemic levels (level/dose) of fluoxetine (FLX) and norfluoxetine (NorFLX) during pregnancy and early postpartum.The authors evaluated 17 pregnant women who received fluoxetine therapy. Doses were recorded weekly across
Dorothy, Sit, James M, Perel, James F, Luther, Stephen R, Wisniewski, Joseph C, Helsel, Katherine L, Wisner   +5 more
openaire   +2 more sources

Automated HPLC assay of fluoxetine and norfluoxetine in serum

Clinical Chemistry, 1994
Abstract This automated assay determines the concentration of the antidepressant fluoxetine (Prozac) and its active metabolite norfluoxetine in serum by reversed-phase HPLC with spectrophotometric detection. Extraction, injection, and quantification are performed by the Gilson Aspec automated sample handler.
J H, Nichols, J R, Charlson, G M, Lawson
openaire   +2 more sources

Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine [PDF]

Water, 2022
The occurrence of psychopharmaceuticals in aquatic ecosystems is a growing problem. Fluoxetine (FL) and its metabolite norfluoxetine (NF) are selective serotonin reuptake inhibitors. Although they may be potentially harmful to non-target species, available knowledge on the effects of NF is sparse, relative to FL. This study aimed at contributing to the
Pedro Rodrigues, Virgínia Cunha, Marta Ferreira, Maria Armanda Reis-Henriques, Luís Oliva-Teles, Laura Guimarães, António Paulo Carvalho   +6 more
openaire   +1 more source

Widespread monitoring of chiral pharmaceuticals in urban rivers reveals stereospecific occurrence and transformation

Environment International, 2020
The present work aimed to discuss the enantiomeric occurrence of chiral pharmaceuticals including 5 parent compounds (PCs) metoprolol, propranolol, atenolol, venlafaxine and fluoxetine as well as 6 of their transformation products (TPs) in surface water ...
Ruixue Ma, Han Qu, Bin Wang, Fang Wang, Gang Yu   +4 more
doaj   +1 more source

Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast‐feeding [PDF]

British Journal of Clinical Pharmacology, 2005
AimsTo compare the disposition of fluoxetine and norfluoxetine enanantiomers in the mother, foetus and infant.MethodsBlood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery.
Kim, John, Riggs, K Wayne, Misri, Shaila, Kent, Nancy, Oberlander, Tim F, Grunau, Ruth E, Fitzgerald, Colleen, Rurak, Dan W   +7 more
openaire   +3 more sources

Acute Urinary Retention Following Low‐Dose Risperidone in a Young Woman: A Case Report

Case Reports in Psychiatry, Volume 2026, Issue 1, 2026.
Risperidone is a widely used antipsychotic for psychotic disorders and is also used as an adjunctive treatment for many psychiatric conditions. While acute urinary retention is more commonly associated with antipsychotics that have anticholinergic effects, it is a rare adverse effect of risperidone.
Obada Zain, Mhd Omar Iyoun, Jana Ebido, Salma Khadem Alsrouji, Youssef Latifeh, Toshiya Inada   +5 more
wiley   +1 more source

Label‐Free Electrochemical Impedance Spectroscopy for Biosensing: Evolving Interfaces and Mechanistic Insights

Small Science, Volume 5, Issue 12, December 2025.
Electrochemical impedance spectroscopy‐based label‐free biosensors offer rapid, direct, and sensitive analyte detection by measuring impedance changes in real time. Innovations in nanoengineered electrode surfaces and biorecognition elements have enhanced their performance facilitating point‐of‐care applications, despite ongoing challenges in ...
Nandhinee Radha Shanmugam, Joshua Rainbow, Jeong‐Chan Lee, Pawan Jolly, Donald E. Ingber   +4 more
wiley   +1 more source