Results 81 to 90 of about 838,377 (285)
Complement Factor H: solution structures and interactions with ligands
, 2009 Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
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BMC Neuroscience, 2006 Background Neuroprotective strategies for prevention of the neuropathological sequelae of traumatic brain injury (TBI) have largely failed in translation to clinical treatment.
Huber-Lang Markus +11 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes
, 2010 The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
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Finite solvable groups with a nilpotent normal complement subgroup
, 2023 Let $G$ be a finite solvable group and $H$ a non-normal core-free subgroup of $G$. We show that if the normalizer of any non-trivial normal subgroup of $Fit(H)$ is equal $H$, then $H$ has a nilpotent normal complement $K$ such that $G=KH$ and $KZ(Fit(H))$
Amiri, Mohsen
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Mesiodens Penyebab Malposisi Gigi Insisif Sentral pada Periode Geligi Bercampur (Laporan Kasus)
Journal of Dentistry Indonesia, 2015 Supernumerary teeth are teeth added to normal complement of teeth. Mesiodens is a special and frequent type of supernumerary teeth, that usually conical, one or two teeth and located at or near the midline in the incisal region of the maxilla.
Rastia Indriyati +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2009 Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in people over the age of 50 in the developed world. Inflammation has a central role in the pathobiology of AMD; complement pathway dysfunction is thought to induce
Longville, Brooke Allison Cattell
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 1981 We have studied the effect of dialysates from lung cancer homogenates to alter both the expression of complement (C3b) receptors per se and also to inhibit leucoattractant-induced enhancement of complement rosettes on monocytes from healthy individuals ...
Kay, A B, Abell, C A, Glass, E J
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