Results 91 to 100 of about 838,377 (285)

Associations of cerebrospinal fluid complement proteins with Alzheimer’s pathology, cognition, and brain structure in non-dementia elderly

Alzheimer’s Research & Therapy
Background Cerebrospinal fluid (CSF) complement activation is a key part of neuroinflammation that occurs in the early stages of Alzheimer’s disease (AD).
Meng Li, Ya-Hui Ma, Yun Guo, Jia-Yao Liu, Lan Tan, on behalf of Alzheimer’s Disease Neuroimaging Initiative   +5 more
doaj   +1 more source

Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

Journal of Neuroinflammation, 2010
Background Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
Tsokos George C, Simovic Milomir, Dalle Lucca Shawn L, Li Yansong, Wang Ying, Dalle Lucca Jurandir J   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli

, 1986
Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli. Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoper-oxidase technique for the histological study of normal ...
Feucht, Helmut E., Zwirner, Jörg, O'Neill, Geoffrey J., Gokel, Michael J., Held, Eckhard, Jung, Christina M., Brase, Angelika, Riethmüller, Gert   +7 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Usefulness and analytical performances of complement multiplex assay for measuring complement biomarkers in plasma

International audienceIntroduction. The complement system is involved in numerous diseases, through diverse mechanisms and degree of activation. With the emergence of complement targeting therapeutic, simple and accessible tools to evaluate the extent of
Courbebaisse, Marie, Duval, Anna, Vieira-Martins, Paula, Chauvet, Sophie, Grunenwald, Anne, Peliconi, Julie, Frémeaux-Bacchi, Véronique, Dragon-Durey, Marie-Agnès, Meuleman, Marie-Sophie, Friedlander, Gérard, Revel, Margot, Rezola Artero, Mikel, Dermani, Mohamed, Roumenina, Lubka, Parfait, Béatrice, Lebeaux, David   +15 more
core   +1 more source

Coagulation/complement cascade genes.

, 2014
Gene identifier, description, and direction of change, of the differentially expressed genes involved in the coagulation/complement cascade for retarded compared with normal buffalo embryos on Day 27 of development are reported.
Domenico Vecchio (529385), Maurizio D'Esposito (529386), Bianca Gasparrini (529379), Romina Francioso (529381), Michael John D'Occhio (529387), Cristina Rossetti (529382), Maria Strazzullo (529378), Maria Rosaria De Filippo (529383), Maria Luisa Balestrieri (482491), Serena Di Francesco (529384), Luigi Zicarelli (529388), Gianluca Neglia (529380), Giovanni Nassa (527001), Alessandro Weisz (90872), Giuseppe Campanile (529389)   +14 more
core   +1 more source