Results 101 to 110 of about 765,441 (312)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Advances in Medical Education and Practice, 2020 Azizollah Arbabisarjou,1 Maryam Akbarilakeh,2 Fatemeh Soroush,3 Abolfazl Payandeh4 1Department of Nursing Management, Zahedan University of Medical Sciences, Zahedan, Iran; 2Department of Medical Education, School of Management and Medical Education ...
Arbabisarjou A +3 more
doaj
Metabolites, 2019 Metabolomics, understood as the science that manages the study of compounds from the metabolism, is an essential tool for deciphering metabolic changes in disease.
Juan Rodríguez-Coira +9 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Ciudades, 2018 This article will discuss the residentialization of French peripheries, an urban renewal process based on the replacement of large groups of social housing by small, closed residential units.
Noel Antonio Manzano Gómez
doaj +1 more source
Journal of Symbolic Computation, 2010 We present a new algorithm to compute the integral closure of a reduced Noetherian ring in its total ring of fractions. A modification, applicable in positive characteristic, where actually all computations are over the original ring, is also described.
Greuel, G.-M. +2 more
openaire +6 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
TRON-Bioinformatics/tronflow-variant-normalization: TronFlow variant normalization v1.1.0
, 2021 Changes: Add support for VCFs without INFO/AD annotations using --vcf_without_ad Add better support for single VCFs through ...
Pablo Riesgo-Ferreiro
core +1 more source
Normalizers and self-normalizing subgroups II
Open Mathematics, 2011 Abstract Let $\mathbb{K}$ be a field, G a reductive algebraic $\mathbb{K}$-group, and G 1 ≤ G a reductive subgroup. For G 1 ≤ G, the corresponding groups of $\mathbb{K}$-points, we study the normalizer N = N G(G 1).
openaire +4 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source