Results 81 to 90 of about 1,695,800 (292)

Simplified Normalization of C-Band Synthetic Aperture Radar Data for Terrestrial Applications in High Latitude Environments

Remote Sensing, 2018
Synthetic aperture radar (SAR) applications often require normalization to a common incidence angle. Angular signatures of radar backscatter depend on surface roughness and vegetation cover, and thus differ, from location to location.
Barbara Widhalm, Annett Bartsch, Robert Goler   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Developing WASPAS-RTB method for range target-based criteria: toward selection for robust design

Technological and Economic Development of Economy, 2018
Recently, considerable attention has been devoted to application of multi-attribute decision-making (MADM) method in materials selection. Normalization can be considered as a foundation for rational MADM methods, which should deal with target-based ...
Ali Jahan
doaj   +1 more source

Validation of Suitable Reference Genes for Gene Expression Studies on Yak Testis Development

Animals, 2020
Testis has an important function in male reproduction. Its development is regulated by a large number of genes. The real-time reserve transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a useful tool to evaluate the gene expression levels ...
Xuelan Zhou, Xiaoyun Wu, Min Chu, Chunnian Liang, Xuezhi Ding, Jie Pei, Lin Xiong, Pengjia Bao, Xian Guo, Ping Yan   +9 more
doaj   +1 more source

From the Birkhoff-Gustavson normalization to the Bertrand-Darboux integrability condition

, 2000
The Bertrand-Darboux integrability condition for a certain class of perturbed harmonic oscillators is studied from the viewpoint of the Birkhoff-Gustavson(BG)-normalization: By solving an inverse problem of the BG-normalization on computer algebra, it is
Arnold V I, Chekanov N A, Cushman R, Darboux G, Goldstein H, Grosche C, Kummer M, Moser J K, Perelomov A M, Spivak M, Uwano Y, Uwano Y, Uwano Y, Uwano Y, Uwano Y, Whittaker E T, Yamaguchi Y Y, Yoshio Uwano   +17 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Discriminative Learning for Alzheimer’s Disease Diagnosis via Canonical Correlation Analysis and Multimodal Fusion

Frontiers in Aging Neuroscience, 2016
To address the challenging task of diagnosing neurodegenerative brain disease, such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI), we propose a novel method using discriminative feature learning and canonical correlation analysis (CCA ...
Baiying eLei, Siping eChen, Dong eNi, Tianfu eWang   +3 more
doaj   +1 more source

Towards a new crown indicator: Some theoretical considerations [PDF]

, 2010
The crown indicator is a well-known bibliometric indicator of research performance developed by our institute. The indicator aims to normalize citation counts for differences among fields.
van Eck, Nees Jan, van Leeuwen, Thed N., van Raan, Anthony F. J., Visser, Martijn S., Waltman, Ludo   +4 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source