Results 71 to 80 of about 1,695,800 (292)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Invariance principles for standard-normalized and self-normalized random fields [PDF]
, 2005 We investigate the invariance principle for set-indexed partial sums of a stationary field $(X\_{k})\_{k\in\mathbb{Z}^{d}}$ of martingale-difference or independent random variables under standard-normalization or self-normalization respectively.Comment ...
Machkouri, Mohamed El, Ouchti, Lahcen
core +3 more sources
Normalizing the Normalizers: Comparing and Extending Network Normalization Schemes
, 2016 Normalization techniques have only recently begun to be exploited in supervised learning tasks. Batch normalization exploits mini-batch statistics to normalize the activations. This was shown to speed up training and result in better models. However its success has been very limited when dealing with recurrent neural networks.
Ren, Mengye +4 more
openaire +3 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Silence and Denial in Everyday Life—The Case of Animal Suffering
Animals, 2011 How can we make sense of the fact that we live in a world where good people co-exist in silence about widespread animal suffering. How is it that sites of suffering such as laboratories, factory farms, abattoirs and animal transportation are all around ...
Deidre Wicks
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Conceptual normalization of senar terminological neologisms [PDF]
Ziglôbitha, 2022 : Terminologies’ Conceptual Normalization (P. I. Coulibaly, 2018, p. 429), a linguistic approach of terminology normalization within the theoretical framework of optimal terminology (P. I. Coulibaly, 2016) is based on the morphological (K. O.
ASSANVO Amoikon Dyhie +1 more
doaj
CrossNorm: Normalization for Off-Policy TD Reinforcement Learning
, 2019 Off-policy temporal difference (TD) methods are a powerful class of reinforcement learning (RL) algorithms. Intriguingly, deep off-policy TD algorithms are not commonly used in combination with feature normalization techniques, despite positive effects ...
Amiranashvili, Artemij +3 more
core
Successive normalization of rectangular arrays
, 2013 Standard statistical techniques often require transforming data to have mean $0$ and standard deviation $1$. Typically, this process of "standardization" or "normalization" is applied across subjects when each subject produces a single number.
Olshen, Richard A., Rajaratnam, Bala
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source