Results 91 to 100 of about 164,930 (254)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Supplemental Material for "Dynamic Normalization" [PDF]

, 2020
Matlab code in this directory computes the results published in: Heeger DJ, Zemlianova KO, A recurrent circuit implements normalization, simulating the dynamics of V1 activity, Proceedings of the National Academy of Sciences, 2020.
Heeger, David J., Zemlianova, Klavdia O.
core   +2 more sources

Discriminative Learning for Alzheimer’s Disease Diagnosis via Canonical Correlation Analysis and Multimodal Fusion

Frontiers in Aging Neuroscience, 2016
To address the challenging task of diagnosing neurodegenerative brain disease, such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI), we propose a novel method using discriminative feature learning and canonical correlation analysis (CCA ...
Baiying eLei, Siping eChen, Dong eNi, Tianfu eWang   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A simulation comparison of normalization procedures for TOPSIS

, 2009
Multiattribute decision making (MADM) uses a normalization procedure to transform performance ratings with different data measurement units in a decision matrix into a compatible unit.
Chung-Hsing Yeh, Chakraborty, Subrata, Yeh, Chung-Hsing, Subrata Chakraborty   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Unemployment Normalization in Different Economic Contexts

, 2017
peer reviewedA recent strand of research has raised the question of whether a change is underway in the relationships that people have with work and nonwork.
Claude Houssemand, Anne Pignault, PIGNAULT, Anne, HOUSSEMAND, Claude   +3 more
core   +2 more sources

Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification

Frontiers in Pharmacology, 2018
Sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) has emerged as one of the most popular techniques for label-free proteome quantification in current pharmacoproteomic research.
Jianbo Fu, Jing Tang, Jing Tang, Yunxia Wang, Xuejiao Cui, Xuejiao Cui, Qingxia Yang, Qingxia Yang, Jiajun Hong, Xiaoxu Li, Xiaoxu Li, Shuang Li, Shuang Li, Yuzong Chen, Weiwei Xue, Feng Zhu, Feng Zhu   +16 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Boolean Algebra Approach for Class Hierarchy Normalization [PDF]

, 1997
Normalization in object-oriented design is much different from that in relational database design. Not only are the conceptual data model of object-oriented (o-o) models integrating richer structuring capabilities than that of relational models, but also
Jitian Xiao, Xiao, Jitian, Yanchun Zhang, Zhang, Yanchun   +3 more
core   +1 more source