Results 91 to 100 of about 864,283 (303)

Validation of Suitable Reference Genes for Gene Expression Studies on Yak Testis Development

Animals, 2020
Testis has an important function in male reproduction. Its development is regulated by a large number of genes. The real-time reserve transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a useful tool to evaluate the gene expression levels ...
Xuelan Zhou, Xiaoyun Wu, Min Chu, Chunnian Liang, Xuezhi Ding, Jie Pei, Lin Xiong, Pengjia Bao, Xian Guo, Ping Yan   +9 more
doaj   +1 more source

Background levels of heavy metals in surficial sediments of the Gulf of Lions (NW Mediterranean): An approach based on 133Cs normalization and lead isotope measurements [PDF]

, 2005
This paper presents an attempt to reach natural background levels of heavy metals in surficial sediments of the Gulf of Lions(NW Mediterranean). To correct for the grain-size effect, normalization procedures based on a clay mineral indicator element are ...
Probst, Jean-Luc, Ludwig, Wolfgang, Roussiez, Vincent, Monaco, André   +3 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Discriminative Learning for Alzheimer’s Disease Diagnosis via Canonical Correlation Analysis and Multimodal Fusion

Frontiers in Aging Neuroscience, 2016
To address the challenging task of diagnosing neurodegenerative brain disease, such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI), we propose a novel method using discriminative feature learning and canonical correlation analysis (CCA ...
Baiying eLei, Siping eChen, Dong eNi, Tianfu eWang   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A biomechanical approach to iris normalization [PDF]

, 2015
The richness of the iris texture and its variability across individuals make it a useful biometric trait for personal authentication. One of the key stages in classical iris recognition is the normalization process, where the annular iris region is ...
Clark, Antwan D., Tomeo-Reyes, Inmaculada, Ross, Arun, Inmaculada Tomeo-Reyes, Antwan D. Clark, Chandran, Vinod, Vinod Chandran, Arun Ross, Clark, Antwan D   +8 more
core   +2 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification

Frontiers in Pharmacology, 2018
Sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) has emerged as one of the most popular techniques for label-free proteome quantification in current pharmacoproteomic research.
Jianbo Fu, Jing Tang, Jing Tang, Yunxia Wang, Xuejiao Cui, Xuejiao Cui, Qingxia Yang, Qingxia Yang, Jiajun Hong, Xiaoxu Li, Xiaoxu Li, Shuang Li, Shuang Li, Yuzong Chen, Weiwei Xue, Feng Zhu, Feng Zhu   +16 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Validation and Normalization of Grasha–Riechmann Teaching Style Inventory in Faculty Members of Zahedan University of Medical Sciences

Advances in Medical Education and Practice, 2020
Azizollah Arbabisarjou,1 Maryam Akbarilakeh,2 Fatemeh Soroush,3 Abolfazl Payandeh4 1Department of Nursing Management, Zahedan University of Medical Sciences, Zahedan, Iran; 2Department of Medical Education, School of Management and Medical Education ...
Arbabisarjou A, Akbarilakeh M, Soroush F, Payandeh A   +3 more
doaj