Results 11 to 20 of about 566,967 (348)

Implications of notch signaling in duchenne muscular dystrophy

Frontiers in Physiology, 2022
This review focuses upon the implications of the Notch signaling pathway in muscular dystrophies, particularly Duchenne muscular dystrophy (DMD): a pervasive and catastrophic condition concerned with skeletal muscle degeneration.
Lily Den Hartog, Atsushi Asakura
doaj   +1 more source

Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state

eLife, 2020
To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms that govern these processes are incompletely understood.
Christian SM Helker, Jean Eberlein, Kerstin Wilhelm, Toshiya Sugino, Julian Malchow, Annika Schuermann, Stefan Baumeister, Hyouk-Bum Kwon, Hans-Martin Maischein, Michael Potente, Wiebke Herzog, Didier YR Stainier   +11 more
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HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium

Frontiers in Oncology, 2021
Blocking tumor angiogenesis is an appealing therapeutic strategy, but to date, success has been elusive. We previously identified HEYL, a downstream target of Notch signaling, as an overexpressed gene in both breast cancer cells and as a tumor ...
Liangfeng Han, Preethi Korangath, Nguyen K. Nguyen, Adam Diehl, Soonweng Cho, Wei Wen Teo, Leslie Cope, Manfred Gessler, Lewis Romer, Lewis Romer, Lewis Romer, Lewis Romer, Lewis Romer, Saraswati Sukumar   +13 more
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A review of the structure and function of vital registration system in Ghana: Towards improvement in mortality data quality for health policy analysis

Journal of Public Health in Africa, 2011
Vital registration systems (VRS) are important in the collection of routine data on indicators of development. These are particularly useful if they are properly built to address weaknesses in the system leading to poor data quality.
Julius N. Fobil, Eunice Aryee, Francis Bilson, Juergen May, Alexander Kraemer   +4 more
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A Regulatory Loop Involving Notch and Wnt Signaling Maintains Leukemia Stem Cells in T-Cell Acute Lymphoblastic Leukemia

Frontiers in Cell and Developmental Biology, 2021
Leukemia-initiating cells play critical role in relapse, resistance to therapies and metastases but the mechanism remains largely elusive. We report that β-catenin is over-expressed in almost all T-ALL patients and flow sorted β-cateninhigh fractions are
Ling Zhang, Jieying Wu, Yashu Feng, Bijay Khadka, Zhigang Fang, Jiaming Gu, Baoqiang Tang, Ruozhi Xiao, Guangjin Pan, Jia-Jun Liu   +9 more
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Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
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Influence of a Pronounced Pre-Deformation on the Attachment of Melt Droplets and the Fatigue Behavior of Laser-Cut AISI 304

Metals, 2023
Laser cutting is a suitable manufacturing method for generating complex geometries for sheet metal components. However, their cyclic load capacity is reduced compared to, for example, milled components. This is due to the influence of the laser-cut edge,
André T. Zeuner, Thomas Wanski, Sebastian Schettler, Jonas Fell, Andreas Wetzig, Robert Kühne, Sarah C. L. Fischer, Martina Zimmermann   +7 more
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Evaluation of the stress singularities of plane V-notches in bonded dissimilar materials [PDF]

, 2008
According to the linear theory of elasticity, there exists a combination of different orders of stress singularity at a V-notch tip of bonded dissimilar materials. The singularity reflects a strong stress concentration near the sharp V-notches.
Ascher, Barsoum, Bogy, Carpenter, Carpinteri, Changzheng Cheng, Chen, Chue, Dali Ge, Delale, Fu, Gadi, Gladwell, Gross, Henshel, Hwu, Hwu, Jian, Jianqiao Ye, Labossiere, Li, Naman Recho, Niu, Pageau, Rzasnicki, Seweryn, Stern, Stroh, Sue, Tan, Ting, Ting, Wigger, Williams, Williams, Yosibash, Zhongrong Niu   +36 more
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Experimental and Numerical Investigation of the Mesoscale Size Effect in Notched Woven Composites

Applied Sciences, 2023
The uniaxial strength of 2 × 2 twill carbon fiber-epoxy composite with circular open holes is governed by the stress concentration induced by the notch, as well as by the variation of the material response with the stress localization.
Andrea Ferrarese, Carlo Boursier Niutta, Alberto Ciampaglia, Raffaele Ciardiello, Davide S. Paolino, Giovanni Belingardi   +5 more
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Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. [PDF]

, 2017
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II
Brumwell, Alexis N, Chapman, Harold A, Driver, Ian H, Gotts, Jeffrey E, Jackson, Julia R, Kim, Thomas, Lee, Dong-Kee, Matthay, Michael A, Shannon, John M, Tan, Victor, Vaughan, Andrew E, Wei, Ying, Xi, Ying, Xu, Jianming   +13 more
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