Results 11 to 20 of about 671,109 (238)
Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Kongming Wu, Qian Chu
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Nature Reviews Molecular Cell Biology, 2016 The highly conserved Notch signalling pathway functions in many different developmental and homeostatic processes, which raises the question of how this pathway can achieve such diverse outcomes.
Sarah Bray
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Notch Signaling in the Tumor Microenvironment
Cancer Cell, 2018 The Notch signaling pathway regulates many aspects of cancer biology. Most attention has been given to its role in the transformed cell. However, it is now clear that cancer progression and metastasis depend on the bidirectional interactions between ...
Olivier Meurette, P. Mehlen
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Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
Cell, 2018 Meghan S Mooring +2 more
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The Varied Roles of Notch in Cancer
Annual Review of Pathology: Mechanisms of Disease, 2017 Jon C Aster +2 more
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The Notch signaling pathway: a potential target for cancer immunotherapy
Journal of Hematology & Oncology, 2023 Dysregulation of the Notch signaling pathway, which is highly conserved across species, can drive aberrant epigenetic modification, transcription, and translation.
Xinxin Li +5 more
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Indian Journal of Medical Specialities, 2022 Background: Novel coronavirus disease-2019 (COVID-19) has become a public emergency that is characterized by a dysregulated immune response and hypercoagulable state.
Dilay Karabulut +6 more
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Biophysics of Notch Signaling.
Annual Review of Biophysics, 2021 Notch signaling is a conserved system of communication between adjacent cells, influencing numerous cell fate decisions in the development of multicellular organisms. Aberrant signaling is also implicated in many human pathologies. At its core, Notch has
D. Sprinzak, S. Blacklow
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Materials Research, 2023 Complete understanding of the local stress triaxiality and stress concentration is essential to ensuring structural safety of several structures. A combination of mechanical tests with numerical simulations can be used to obtain this information. One way
Letícia dos Santos Pereira +2 more
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Frontiers in Cell and Developmental Biology, 2021 The Notch signaling pathway plays an essential role in a wide variety of biological processes including cell fate determination of vascular endothelial cells and the regulation of arterial differentiation and angiogenesis.
Abdellah Akil +6 more
semanticscholar +1 more source