Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish
Journal of Developmental Biology, 2023 Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal ...
Bridgette E. Drummond +2 more
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Analysis of Various Chevron Notch Types and its Influence on the Ligament Area [PDF]
, 2019 Specimens for the bending tests with the chevron notch are standardized for the evaluation of the fracture toughness of various materials. In this contribution a difference of the ligament area of the specimens with the straight through notch and the
Miarka, Petr +3 more
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Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]
, 2009 Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Jones, E. A., Naylor, Richard William
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Journal of Pediatric Orthopaedics B, 1997 Ultrasound images of dysplastic and/or unstable hips often display an indentation or notch at the superolateral part of the acetabulum where the iliac wing joins the acetabular roof. We reviewed the ultrasound and subsequent radiographic examinations of 295 babies examined in our hip screening clinic.
N.M. Portinaro, D. Murray, M. K. Benson
openaire +3 more sources
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]
, 2017 Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio +4 more
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The developmental origins of Notch-driven intrahepatic bile duct disorders
Disease Models & Mechanisms, 2021 The Notch signaling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence of
Anabel Martinez Lyons, Luke Boulter
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Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation [PDF]
, 2018 Glioblastoma (GBM) is the most aggressive human brain tumor. The high growth potential and decreased susceptibility to apoptosis of the glioma cells is mainly dependent on genetic amplifications or mutations of oncogenic or pro-apoptotic genes ...
Bevilacqua, Valeria +8 more
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Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]
, 2019 The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I +20 more
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Microorganisms, 2020 Despite the extensive research on Notch signaling involvement in inflammation, its specific role in macrophage response in autoimmune disease and defense mechanisms against bacterial infection, such as Mycobacterium avium paratuberculosis (MAP), remains ...
Esra’a Keewan, Saleh A. Naser
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Fatigue Behaviour of Aluminium Members with Different Notch Root Shapes
Buildings, 2022 In unitised curtain walls, the transfer of horizontal loads, mainly wind loads, from the upper into the lower unit is achieved through the head/notch interlocking connection.
Nebojša Buljan +3 more
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