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Notch signaling and Notch signaling modifiers [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
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The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]
, 2011 Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
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Frontiers in Immunology, 2018 The Notch pathway plays critical roles in the development and functional modulation of myeloid cells. Previous studies have demonstrated that Notch activation promotes M1 polarization and phagocytosis of macrophages; however, the downstream molecular ...
Yan Lin +13 more
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The role of the notch signalling pathway in vascular smooth muscle cell apoptosis [PDF]
, 2004 The Notch signalling system is a highly conserved method of cell-to-cell communication involved in cell fate decisions in many cell types. Until recently, the importance of the Notch signalling pathway was recognized in the embryonic but not in the adult
Sweeney, Catherine Helena
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Notch signaling pathway in human vascular smooth muscle cell differentiation [PDF]
, 2006 Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to ...
Scheller, Agnieszka
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eLife, 2016 Drosophila hematopoiesis bears striking resemblance with that of vertebrates, both in the context of distinct phases and the signaling molecules. Even though, there has been no evidence of Hematopoietic stem cells (HSCs) in Drosophila, the larval lymph ...
Nidhi Sharma Dey +4 more
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iScienceSummary: Acute lung injury (ALI) is a severe pulmonary inflammatory disease with high morbidity and mortality rates. The pulmonary inflammatory phenotype of ALI is driven by the excessive aggregation and activation of neutrophils, triggering a cytokine ...
Xinyu Wu +13 more
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Frontiers in Cell and Developmental Biology, 2022 Organ development, homeostasis, and repair often rely on bidirectional, self-organized cell-niche interactions, through which cells select cell fate, such as stem cell self-renewal and differentiation.
Chin-Lin Guo
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CambridgeCentreForProteomics/notch: bioRxiv manuscript
, 2021 Analysis of a benchmark human:yeast dataset to examine the notch in TMT ...
Tom Smith
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European Journal of BiologyObjective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
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