Results 21 to 30 of about 261,437 (315)

Notch signaling and Notch signaling modifiers [PDF]

The International Journal of Biochemistry & Cell Biology, 2011
Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
openaire   +2 more sources

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]

, 2013
The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn, Rothman, A.M.K., Gray, Caroline, Haase, A., Haase, Andrea, Novodvorsky, P., Rothman, Alexander M K, Van Eeden, Fredericus J. M., Gering, Martin, Crossman, D.C., Chico, Timothy J. A., Watson, O., Crossman, David C, Chico, Timothy J A, Gering, M., Rothman, Alexander M. K., Crossman, David C., Novodvorsky, Peter, Lawrie, A., McMahon, K., Van Eeden, Fredericus J M, Lawrie, Allan, Van Eeden, F.J.M., Chico, T.J.A., Watson, Oliver, Gray, C.   +25 more
core   +1 more source

Notch and the Skeleton [PDF]

Molecular and Cellular Biology, 2010
Notch receptors are transmembrane receptors that regulate cell fate decisions. There are four Notch receptors in mammals. Upon binding to members of the Delta and Jagged family of transmembrane proteins, Notch is cleaved and the Notch intracellular domain (NICD) is released.
Stefano, Zanotti, Ernesto, Canalis
openaire   +2 more sources

Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression

Frontiers in Immunology, 2018
The Notch pathway plays critical roles in the development and functional modulation of myeloid cells. Previous studies have demonstrated that Notch activation promotes M1 polarization and phagocytosis of macrophages; however, the downstream molecular ...
Yan Lin, Yan Lin, Yan Lin, Jun-Long Zhao, Jun-Long Zhao, Qi-Jun Zheng, Xun Jiang, Jiao Tian, Shi-Qian Liang, Hong-Wei Guo, Hong-Yan Qin, Ying-Min Liang, Hua Han, Hua Han   +13 more
doaj   +1 more source

Compact Electromagnetic Bandgap Structures for Notch Band in Ultra-Wideband Applications [PDF]

, 2010
This paper introduces a novel approach to create notch band filters in the front-end of ultra-wideband (UWB) communication systems based on electromagnetic bandgap (EBG) structures.
Jan Sykulski, Rotaru, M., Mihai Rotaru, Sykulski, J.K.   +3 more
core   +1 more source

Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach [PDF]

, 2011
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...

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Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila

eLife, 2016
Drosophila hematopoiesis bears striking resemblance with that of vertebrates, both in the context of distinct phases and the signaling molecules. Even though, there has been no evidence of Hematopoietic stem cells (HSCs) in Drosophila, the larval lymph ...
Nidhi Sharma Dey, Parvathy Ramesh, Mayank Chugh, Sudip Mandal, Lolitika Mandal   +4 more
doaj   +1 more source

Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity [PDF]

, 2017
Abnormal enlargement of the alveolar spaces is a hallmark of conditions such as chronic obstructive pulmonary disease and bronchopulmonary dysplasia.
林泰元;曹伯年;魏淑?, Tsao, Po-Nien;Matsuoka, Chisa;Wei, Shu-Chen;Sato, Atsuyasu;Sato, Susumu;Hasegawa, Koichi;Chen, Hung-kuan;Ling, Thai-Yen;Mori, Munemasa;Cardoso, Wellington V.;Morimoto, Mitsuru   +1 more
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Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury

iScience
Summary: Acute lung injury (ALI) is a severe pulmonary inflammatory disease with high morbidity and mortality rates. The pulmonary inflammatory phenotype of ALI is driven by the excessive aggregation and activation of neutrophils, triggering a cytokine ...
Xinyu Wu, Huijun Liu, Qingwu Qin, Lin Yuan, Ye Yao, Xizi Du, Qiuyan Qin, Leyuan Wang, Qianyu Zhao, Ling Qin, Yang Xiang, Ming Yang, Xiaoqun Qin, Chi Liu   +13 more
doaj   +1 more source

Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis

Frontiers in Cell and Developmental Biology, 2022
Organ development, homeostasis, and repair often rely on bidirectional, self-organized cell-niche interactions, through which cells select cell fate, such as stem cell self-renewal and differentiation.
Chin-Lin Guo
doaj   +1 more source