Results 21 to 30 of about 296,712 (303)

Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice

Frontiers in Immunology, 2020
Intestinal barrier dysfunction and subsequent microbial translocation play crucial roles in persistent immune activation leading to HIV disease progression. Opioid use is associated with worse outcome in HIV-infected patients.
Jingjing Meng, Jingjing Meng, Santanu Banerjee, Santanu Banerjee, Li Zhang, Greg Sindberg, Shamsudheen Moidunny, Bin Li, David J. Robbins, Mohit Girotra, Bradley Segura, Sundaram Ramakrishnan, Sabita Roy, Sabita Roy   +13 more
doaj   +1 more source

A Notch updated [PDF]

Journal of Cell Biology, 2009
Cell–cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identified for some time, but the study of the modulation of the pathway in different cellular ...
Tien, An-Chi, Rajan, Akhila, Bellen, Hugo J.   +2 more
openaire   +2 more sources

The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica [PDF]

Open Biology, 2016
The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell ...
Paula Irles, Nashwa Elshaer, Maria-Dolors Piulachs   +2 more
doaj   +1 more source

Bending Resistance and Failure Type Evaluation of Basalt Fiber RPC Beam Affected by Notch and Interfacial Damage Using Acoustic Emission

Applied Sciences, 2020
Generally, reactive powder concrete (RPC) contains steel fibers often exposed to aggressive environments. Steel fibers in such RPCs are subjected to corrosion in-service, which can significantly change the mechanical properties of the structural ...
Hanbing Liu, Xiang Lyu, Yuwei Zhang, Guobao Luo, Wenjun Li   +4 more
doaj   +1 more source

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
core   +1 more source

Study of the Notch-Aromatic Hydrocarbon Receptor-Interleukin-22 Signaling Pathway and the Pathogenesis of Immune Thrombocytopenia

Clinical and Experimental Obstetrics & Gynecology, 2023
Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms ...
Qian-qian Fan, Rong-xia He
doaj   +1 more source

Notch in the Niche [PDF]

Cell Stem Cell, 2008
Notch signaling is essential for hematopoietic stem cell (HSC) formation during embryogenesis, and hitherto it was also thought to be required for HSC maintenance. However, in this issue of Cell Stem Cell, Maillard et al. (2008) demonstrate rather conclusively that inactivation of the Notch pathway in HSCs does not interfere with their self-renewal.
Gering, M, Patient, R
openaire   +1 more source

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]

, 2013
The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn, Rothman, A.M.K., Gray, Caroline, Haase, A., Haase, Andrea, Novodvorsky, P., Rothman, Alexander M K, Van Eeden, Fredericus J. M., Gering, Martin, Crossman, D.C., Chico, Timothy J. A., Watson, O., Crossman, David C, Chico, Timothy J A, Gering, M., Rothman, Alexander M. K., Crossman, David C., Novodvorsky, Peter, Lawrie, A., McMahon, K., Van Eeden, Fredericus J M, Lawrie, Allan, Van Eeden, F.J.M., Chico, T.J.A., Watson, Oliver, Gray, C., Crossman, David C.; id_orcid   +26 more
core   +1 more source

Acetabular Notch

Journal of Pediatric Orthopaedics B, 1997
Ultrasound images of dysplastic and/or unstable hips often display an indentation or notch at the superolateral part of the acetabulum where the iliac wing joins the acetabular roof. We reviewed the ultrasound and subsequent radiographic examinations of 295 babies examined in our hip screening clinic.
N.M. Portinaro, D. Murray, M. K. Benson
openaire   +3 more sources

Notch signaling and Notch signaling modifiers [PDF]

The International Journal of Biochemistry & Cell Biology, 2011
Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
openaire   +2 more sources