Congenital diseases caused by defective O-glycosylation of Notch receptors [PDF]
, 2018 2018-08The Notch signaling pathway is highly conserved and essential for animal development. It is required for cell differentiation, survival, and proliferation. Regulation of Notch signaling is a crucial process for human health.
Okajima, Tetsuya, Tashima, Yuko
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European Journal of BiologyObjective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
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Modelling delta-notch perturbations during zebrafish somitogenesis [PDF]
, 2013 The discovery over the last 15 years of molecular clocks and gradients in the pre-somitic mesoderm of numerous vertebrate species has added significant weight to Cooke and Zeeman's ‘clock and wavefront’ model of somitogenesis, in which a travelling ...
Baker, R. E. +8 more
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Notch-Insensitive, Ultrastretchable, Efficient Self-Healing Supramolecular Polymers Constructed from Multiphase Active Hydrogen Bonds for Electronic Applications [PDF]
, 2019 Self-healing polymers with microphase-separated structure are plagued with inferior self-healing efficiency at room temperature due to a lack of dynamic interactions in hard domains.
JianHua Xu (4095571) +6 more
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Notch signalling in T cells: bridging tumour immunity and intratumoral cellular crosstalk
Frontiers in ImmunologyBackgroundNotch receptor–ligand interaction is ubiquitous and fundamental for coordinating cellular differentiation and determining cell fate for the development of various tissues and organs.
Jasmine Sultana +13 more
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Polish Maritime Research, 2018 Like other means of transport, merchant ships face the problem of increasing requirements concerning the environment protection, which, among other issues, implies the reduction of fuel consumption by the ship.
Niklas Karol, Kozak Janusz
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Research progress in the roles of Notch signaling pathway during fracture healing
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
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Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM [PDF]
, 2014 During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene ...
Dale, J. Kim +7 more
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Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics
npj Systems Biology and ApplicationsEngineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality.
Daniel C. Kirouac +2 more
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Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration
eLife, 2020 Neuronal degeneration in the zebrafish retina stimulates Müller glia (MG) to proliferate and generate multipotent progenitors for retinal repair. Controlling this proliferation is critical to successful regeneration.
Mi-Sun Lee, Jin Wan, Daniel Goldman
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