Results 31 to 40 of about 283,620 (310)

Notch signalling in T cells: bridging tumour immunity and intratumoral cellular crosstalk

Frontiers in Immunology
BackgroundNotch receptor–ligand interaction is ubiquitous and fundamental for coordinating cellular differentiation and determining cell fate for the development of various tissues and organs.
Jasmine Sultana, Pritha Roy Choudhury, Saurav Bera, Mohona Chakravarti, Aishwarya Guha, Prodipto Das, Juhina Das, Gayatri S Iyer, Anirban Sarkar, Sukanya Dhar, Nilanjan Ganguly, Rathindranath Baral, Anamika Bose, Saptak Banerjee   +13 more
doaj   +1 more source

The Effect of Numerical 2D and 3D Fem Element Modelling on Strain and Stress Distributions at Laser Weld Notches in Steel Sandwich Type Panels

Polish Maritime Research, 2018
Like other means of transport, merchant ships face the problem of increasing requirements concerning the environment protection, which, among other issues, implies the reduction of fuel consumption by the ship.
Niklas Karol, Kozak Janusz
doaj   +1 more source

Research progress in the roles of Notch signaling pathway during fracture healing

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
doaj   +1 more source

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]

, 2013
The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn, Rothman, A.M.K., Gray, Caroline, Haase, A., Haase, Andrea, Novodvorsky, P., Rothman, Alexander M K, Van Eeden, Fredericus J. M., Gering, Martin, Crossman, D.C., Chico, Timothy J. A., Watson, O., Crossman, David C, Chico, Timothy J A, Gering, M., Rothman, Alexander M. K., Crossman, David C., Novodvorsky, Peter, Lawrie, A., McMahon, K., Van Eeden, Fredericus J M, Lawrie, Allan, Van Eeden, F.J.M., Chico, T.J.A., Watson, Oliver, Gray, C.   +25 more
core   +1 more source

Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics

npj Systems Biology and Applications
Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality.
Daniel C. Kirouac, Cole Zmurchok, Denise Morris   +2 more
doaj   +1 more source

Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

eLife, 2020
Neuronal degeneration in the zebrafish retina stimulates Müller glia (MG) to proliferate and generate multipotent progenitors for retinal repair. Controlling this proliferation is critical to successful regeneration.
Mi-Sun Lee, Jin Wan, Daniel Goldman
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A study of Notch signalling in developmental angiogenesis [PDF]

, 2009
Blood vessel patterning during angiogenesis is a guided process. Endothelial tip cells located at the end of vascular sprouts are important for vessel guidance.
Phng, L.-K., Phng, L-K
core  

Emerging structures and dynamic mechanisms of γ-secretase for Alzheimer’s disease

Neural Regeneration Research
γ-Secretase, called “the proteasome of the membrane,” is a membrane-embedded protease complex that cleaves 150+ peptide substrates with central roles in biology and medicine, including amyloid precursor protein and the Notch family of cell-surface ...
Yinglong Miao, Michael S. Wolfe
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source