Results 31 to 40 of about 523,361 (299)
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. [PDF]
, 2017 After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II
Brumwell, Alexis N +13 more
core +1 more source
Toxics, 2018 Butyrylcholinesterase (BChE) is the evolutionary counterpart to acetylcholinesterase (AChE). Both are expressed early in nervous system development prior to cholinergic synapse formation.
Angela K. Tiethof +2 more
doaj +1 more source
A crack-like notch analogue for a safe-life fretting fatigue design methodology [PDF]
, 2003 Various analogies have recently been proposed for comparing the stress fields induced in fretting fatigue contact situations, with those of a crack and a sharp or a rounded notch, resulting in a degree of uncertainty over which model is most appropriate ...
Ciavarella, M.
core +1 more source
Resolving Astrocyte Heterogeneity in the CNS
Frontiers in Cellular Neuroscience, 2017 Astrocytes play essential roles in nearly all aspects of brain function from modulating synapses and neurovasculature to preserving appropriate extracellular solute concentrations. To meet the complex needs of the central nervous system (CNS), astrocytes
W. Todd Farmer, Keith Murai
doaj +1 more source
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells [PDF]
, 2018 Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands.
Agnusdei, Valentina +11 more
core +3 more sources
Notch signaling and Notch signaling modifiers [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
openaire +2 more sources
Notch one for activating NOTCH [PDF]
Science-Business eXchange, 2011 Vanderbilt researchers have identified downregulation of NOTCH signaling as a mechanism tumors use to evade the immune system, suggesting that restoring activation of the pathway could improve cancer immunotherapy. Researchers have been split on whether it is better to up- or downregulate NOTCH.
openaire +1 more source
iScienceSummary: Acute lung injury (ALI) is a severe pulmonary inflammatory disease with high morbidity and mortality rates. The pulmonary inflammatory phenotype of ALI is driven by the excessive aggregation and activation of neutrophils, triggering a cytokine ...
Xinyu Wu +13 more
doaj +1 more source
eLife, 2015 Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown.
Michelle I Lin +18 more
doaj +1 more source
Pifu-xingbing zhenliaoxue zazhi, 2022 Objective To study effects of phosphoinositide 3 kinase (PI3K) and Notch signaling pathway on the proliferation and activation of CD4+ T cells in peripheral blood of patients with psoriasis vulgaris.
Jia LIU, Ming WEI
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