Results 41 to 50 of about 283,620 (310)

Fatigue life prediction of titanium alloy TA19 based on Weibull distribution and first-order reliability correction

open access: yesCailiao gongcheng
With the improvement in aeroengine performance,critical components (such as centrifugal impellers) operate under high-temperature,high-stress,and complex load conditions.
QUAN Changbiao   +5 more
doaj   +1 more source

Critical Distance Default Values for Structural Steels and a Simple Formulation to Estimate the Apparent Fracture Toughness in U-Notched Conditions

open access: yesMetals, 2018
The structural integrity assessment of components containing notch-type defects has been the subject of extensive research in the last few decades. The assumption that notches behave as cracks is generally too conservative, making it necessary to develop
Sergio Cicero   +4 more
doaj   +1 more source

An Extended Finite Element Method (XFEM) Study on the Elastic T-Stress Evaluations for a Notch in a Pipe Steel Exposed to Internal Pressure

open access: yesMathematics, 2021
The work investigates the importance of the K-T approach in the modelling of pressure cracked structures. T-stress is the constant in the second term of the Williams expression; it is often negligible, but recent literature has shown that there are cases
Khadija Yakoubi   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Macrophage Notch1 Participates in LPS-Induced Acute Lung Injury via Regulating CCR5 Expression in Mice

open access: yesFrontiers in Bioscience-Landmark
Background: As pivotal immunoregulatory sentinels in pulmonary defense systems, alveolar macrophages (AMs) play dual roles in mediating inflammatory responses and tissue repair processes during various phases of inflammatory cascades ...
Ruiyu Zhang   +7 more
doaj   +1 more source

Low-Noise Chopper-Stabilized Multi-Path Operational Amplifier with Nested Miller Compensation for High-Precision Sensors

open access: yesApplied Sciences, 2019
This paper presents a low-noise multi-path operational amplifier for high-precision sensors. A chopper stabilization technique is applied to the amplifier to remove offset and flicker noise.
Jaesung Kim   +7 more
doaj   +1 more source

A notch in time [PDF]

open access: yesBritish Journal of Ophthalmology, 2004
Native to the Indo-Pacific coral reefs, the alluring Korean angelfish ( Pomacanthus semicirculatus ) captivates us with its colourful designs and surprises us with its natural history. As the juvenile angelfish (seen on the cover) matures, its coloration will change to that of an adult so different in coloration that it was considered a different ...
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Modern conception about cellular and molecular mechanisms of angiogenesis

open access: yesУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015
The review contains modern scientific literary data, recently conducted studies, which devoted to studying of molecular, cellular and genetic mechanisms in processes of angiogenesis.
K. A. Khmelnitskaya   +2 more
doaj   +1 more source

Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution

open access: yesFrontiers in Immunology, 2022
Notch signaling is crucial for fate specification and maturation of thymus-seeding progenitors along the T-cell lineage. Recent studies have extended the role of Notch signaling to thymic epithelial cells (TECs), showing that Notch regulates TEC ...
María Jesús García-León   +7 more
doaj   +1 more source

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