Results 41 to 50 of about 523,361 (299)

Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish

eLife
The skin, the largest organ, functions as a primary defense mechanism. Epidermal stem cells supply undifferentiated keratinocytes that differentiate as they migrate toward the outermost skin layer.
Yi Wang, Thomas Nguyen, Qingan He, Oliver Has, Kiarash Forouzesh, Dae Seok Eom   +5 more
doaj   +1 more source

Fast design optimization of UWB antenna with WLAN Band-Notch [PDF]

, 2015
In this paper, a methodology for rapid design optimization of an ultra-wideband ( UWB) monopole antenna with a lower WLAN band-notch is presented. The band-notch is realized using an open loop resonator implemented in the radiation patch of the antenna ...
Bekasiewicz, A, Dhaene, Tom, Koziel, S, Ulaganathan, Selvakumar   +3 more
core   +2 more sources

Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

eLife
Notch signaling has been identified as a key regulatory pathway in patterning the endocardium through activation of endothelial-to-mesenchymal transition (EMT) in the atrioventricular canal (AVC) and proximal outflow tract (OFT) region.
Yunfei Mu, Shijia Hu, Xiangyang Liu, Xin Tang, Jiayi Lin, Hongjun Shi   +5 more
doaj   +1 more source

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled [PDF]

Open Biology, 2015
Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells.
Thomas Mund, Michael Graeb, Juliusz Mieszczanek, Melissa Gammons, Hugh R. B. Pelham, Mariann Bienz   +5 more
doaj   +1 more source

Genome-wide screen for genes involved in Caenorhabditis elegans developmentally timed sleep [PDF]

, 2017
In Caenorhabditis elegans, Notch signaling regulates developmentally timed sleep during the transition from L4 larval stage to adulthood (L4/A) . To identify core sleep pathways and to find genes acting downstream of Notch signaling, we undertook the ...
Hart, Anne C, Hayden, Dustin J, Huang, Huiyan, Skuja, Lukas L, Zhu, Chen-Tseh   +4 more
core   +3 more sources

Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics

npj Systems Biology and Applications
Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality.
Daniel C. Kirouac, Cole Zmurchok, Denise Morris   +2 more
doaj   +1 more source

Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways

Frontiers in Oncology, 2018
Triple negative breast cancer (TNBC) patients have high risk of recurrence and metastasis, and current treatment options remain limited. Cancer stem-like cells (CSCs) have been linked to cancer initiation, progression and chemotherapy resistance.
Fokhrul Hossain, Fokhrul Hossain, Claudia Sorrentino, Claudia Sorrentino, Deniz A. Ucar, Deniz A. Ucar, Yin Peng, Margarite Matossian, Dorota Wyczechowska, Judy Crabtree, Jovanny Zabaleta, Silvana Morello, Luis Del Valle, Matthew Burow, Bridgette Collins-Burow, Antonio Pannuti, Lisa M. Minter, Todd E. Golde, Barbara A. Osborne, Lucio Miele, Lucio Miele   +20 more
doaj   +1 more source

Notch Filtering Suitable for Real Time Removal of Power Line Interference [PDF]

, 2013
This paper presents a high performance notch filtering for real time suppression of power line interference in a general signal. The disturbing signal is suppressed using an optimal notch FIR filter with tunable notch frequency.
Vlcek, M., Zahradnik, P.
core   +1 more source

Biomaterial-based ligand presentation to induce notch signaling in vitro [PDF]

, 2013
T cell adoptive transfer is an important procedure in immunotherapy. In immunocompromised patients, T cells may need to be developed from stem cells, requiring the induction of Notch signaling events responsible for native T cell differentiation in the ...
Mehta, Naveen
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source