Results 41 to 50 of about 196,993 (268)
Frontiers in Immunology, 2022 Notch signaling is crucial for fate specification and maturation of thymus-seeding progenitors along the T-cell lineage. Recent studies have extended the role of Notch signaling to thymic epithelial cells (TECs), showing that Notch regulates TEC ...
María Jesús García-León +7 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Arteriogenesis of the Spinal Cord—The Network Challenge
Cells, 2020 Spinal cord ischemia (SCI) is a clinical complication following aortic repair that significantly impairs the quality and expectancy of life. Despite some strategies, like cerebrospinal fluid drainage, the occurrence of neurological symptoms, such as ...
Florian Simon +4 more
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Current Biology, 1999 What are they? The Notch proteins are transmembrane receptors that regulate differentiation in all types of tissues and organisms. The Notch family includes lin12 and glp1 from Caenorhabditis elegans, and mammalian Notch1 to Notch4. All the Notch proteins have extracellular EGF-like repeats for ligand binding, and intracellular RAM23 and ankyrin ...
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Using XFEM Techniques to Predict the Damage of aluminum 2024T3 notched under tensile load
Fracture and Structural Integrity, 2019 The objective of this work is to analyze some geometrical effect to predict the damage of aluminum 2024T3 structure after validate numerical model by experimental test. The mechanical of damage behaviour under tensile tests of several plates with notches
Benzaama Abdallah +7 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Energies, 2018 Drive motors, which are used in the drive modules of electric cars, are interior permanent magnet motors. These motors tend to have high cogging torque and torque ripple, which leads to the generation of high vibration and noise.
Myeong-Hwan Hwang +2 more
doaj +1 more source
Applied Sciences, 2020 This paper provides a complete overview of the applicability of the Equivalent Material Concept in conjunction with the Average Strain Energy Density criterion, to provide predictions of fracture loads in structural materials containing U-notches.
Sergio Cicero +2 more
doaj +1 more source