Results 41 to 50 of about 296,712 (303)
Notch signalling in T cells: bridging tumour immunity and intratumoral cellular crosstalk
Frontiers in ImmunologyBackgroundNotch receptor–ligand interaction is ubiquitous and fundamental for coordinating cellular differentiation and determining cell fate for the development of various tissues and organs.
Jasmine Sultana +13 more
doaj +1 more source
Polish Maritime Research, 2018 Like other means of transport, merchant ships face the problem of increasing requirements concerning the environment protection, which, among other issues, implies the reduction of fuel consumption by the ship.
Niklas Karol, Kozak Janusz
doaj +1 more source
Research progress in the roles of Notch signaling pathway during fracture healing
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
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The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]
, 2011 Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core +1 more source
Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics
npj Systems Biology and ApplicationsEngineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality.
Daniel C. Kirouac +2 more
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Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration
eLife, 2020 Neuronal degeneration in the zebrafish retina stimulates Müller glia (MG) to proliferate and generate multipotent progenitors for retinal repair. Controlling this proliferation is critical to successful regeneration.
Mi-Sun Lee, Jin Wan, Daniel Goldman
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A study of Notch signalling in developmental angiogenesis [PDF]
, 2009 Blood vessel patterning during angiogenesis is a guided process. Endothelial tip cells located at the end of vascular sprouts are important for vessel guidance.
Phng, L.-K., Phng, L-K
core
Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM [PDF]
, 2014 During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene ...
Dale, J. Kim +7 more
core +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Emerging structures and dynamic mechanisms of γ-secretase for Alzheimer’s disease
Neural Regeneration Researchγ-Secretase, called “the proteasome of the membrane,” is a membrane-embedded protease complex that cleaves 150+ peptide substrates with central roles in biology and medicine, including amyloid precursor protein and the Notch family of cell-surface ...
Yinglong Miao, Michael S. Wolfe
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